≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Room temperature Ships Normal Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist.
Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension. A specific antagonist of the AT1 receptor with significant downstream effects.
Losartan Potassium is a specific antagonist of the angiotensin II receptor subtype AT1. Antagonism of the AT1 receptor and interference of association between AT1 and angiotensin II produces vasodilation and reduction of hypertension. This antagonism has
Storage
Room temperature
Shipped In
Normal
Action Type
ANTAGONIST
Mechanism of action
Type-1 angiotensin II receptor antagonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo. (2023) Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, [PMID:][10.1016/j.jfca.2023.105825]
2.Shasha Liu, Ruohan Cheng, Hui He, Kunming Ding, Rongmi Zhang, Yuanyuan Chai, Qinwei Yu, Xin Huang, Luyong Zhang, Zhenzhou Jiang. (2023) 8-methoxypsoralen protects against acetaminophen-induced liver injury by antagonising Cyp2e1 in mice. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, [PMID:37121295][10.1016/j.abb.2023.109617]
4.Sun Zhiping, He Lingli, Yang Qingqing, Zhang Haizhi, Xu Weiren, Qin Xinguang, Liu Gang, Hu Zhongze, Zhang Luyong, Liu Changxiao. (2022) Study on the Effect of Three CYP2C9 Variants on Drug–Drug Interaction Related to Six Drugs In Vitro by LC–MS/MS Method. CHROMATOGRAPHIA, 85 (3):(221-231). [PMID:][10.1007/s10337-021-04126-8]
5.Yuanyuan Chai, Yunxia Xu, Ziyin Xia, Xin Huang, Luyong Zhang, Zhenzhou Jiang. (2021) Study on the effects of Zhuanggu Guanjie Pill, a modern Chinese medicine formula, on the activities and mRNA expression of seven CYP isozymes in rats. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:34390794][10.1016/j.jep.2021.114521]
6.Lin Yue, Meihong Zheng, Min Wang, Imran Mahmood Khan, Bin Wang, Xiaoyuan Ma, Chifang Peng, Zhouping Wang, Wenshui Xia. (2021) A general strategy to synthesis chitosan oligosaccharide-O-Terpenol derivatives with antibacterial properties. CARBOHYDRATE RESEARCH, [PMID:33865180][10.1016/j.carres.2021.108315]
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