Orlistat - Moligand™, ≥97%(HPLC) , Pancreatic lipase inhibitor, CAS No.96829-58-2, Pancreatic lipase inhibitor

CAS: 96829-58-2 Cat. No.: O159936 Molecular Weight: 495.75 EC Number: 639-755-1
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥97%(HPLC)
Synonyms
CCG-100851 | DTXCID40820067 | ORLISTAT [MART.] | Orlistat, United States Pharmacopeia (USP) Reference Standard | Q424163 | [(2S)-1-[(2R,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2R)-2-formamido-4-methylpentanoate | BDBM24567 | HSDB 7556 | L-Leucine, N-
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
100mg
O159936-100mg
3
$9.90
250mg
O159936-250mg
3
$9.90
1g
O159936-1g
3
$21.90
5g
O159936-5g
3
$37.90
25g
O159936-25g
3
$131.90
100g
O159936-100g
2
$429.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Moligand™, ≥97%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 51 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies suggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3.
Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice

Specifications

Synonyms
CCG-100851 | DTXCID40820067 | ORLISTAT [MART.] | Orlistat, United States Pharmacopeia (USP) Reference Standard | Q424163 | [(2S)-1-[(2R, 3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2R)-2-formamido-4-methylpentanoate | BDBM24567 | HSDB 7556 | L-Leucine, N-
Specifications & Purity
Moligand™, ≥97%(HPLC)
Biochemical and Physiological Mechanisms
Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.Selective, competitive lipase inhibitor (IC 50 = 0.15 µM). Displays antiproliferative and antitumor activity. Active in
Storage
Store at -20°C, Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Pancreatic lipase inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥97%(HPLC)
Names and Identifiers
Pubchem Sid504762354
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504762354
Canonical SmilesCCCCCCCCCCCC(CC1C(C(=O)O1)CCCCCC)OC(=O)C(CC(C)C)NC=O
IUPAC Name[(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate
InChIKeyAHLBNYSZXLDEJQ-FWEHEUNISA-N
INCHI1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
Isomeric SMILES CCCCCCCCCCC[C@@H](C[C@H]1[C@@H](C(=O)O1)CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
WGK Germany 3
RTECS OH3167600
Molecular Weight 495.75
Reaxy-Rn 14346758
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14346758&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
SubclassAmino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct ParentLeucine and derivatives
Alternative Parents Alpha amino acid esters  N-formyl-alpha amino acids  Fatty acid esters  Dicarboxylic acids and derivatives  Beta propiolactones  Secondary carboxylic acid amides  Oxetanes  Carboxylic acid esters  Oxacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic heteromonocyclic compounds
Substituents Leucine or derivatives - Alpha-amino acid ester - N-formyl-alpha amino acid or derivatives - N-formyl-alpha-amino acid - Fatty acid ester - Dicarboxylic acid or derivatives - Fatty acyl - Beta_propiolactone - Carboxamide group - Carboxylic acid ester - Secondary carboxylic acid amide - Oxetane - Lactone - Oxacycle - Organoheterocyclic compound - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Aliphatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as leucine and derivatives. These are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
DAGLB Tchem Sn1-specific diacylglycerol lipase beta (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DAGLA Tchem Sn1-specific diacylglycerol lipase alpha (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FASN Tchem Fatty acid synthase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LPL Tchem Lipoprotein lipase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PNLIP Tclin Pancreatic triacylglycerol lipase (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LIPC Tchem Hepatic triacylglycerol lipase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LIPG Tchem Endothelial lipase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABHD6 Tchem Monoacylglycerol lipase ABHD6 (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABHD12 Tchem Monoacylglycerol lipase ABHD12 (6 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABHD16A Tchem Protein ABHD16A (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLA2G7 Tchem Platelet-activating factor acetylhydrolase (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PNLIP Tclin Pancreatic lipase (198 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LPL Tchem Lipoprotein lipase (101 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR2 Tchem Cannabinoid CB2 receptor (16942 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NPC1L1 Tclin Niemann-Pick C1-like protein 1 (346 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLA2G7 Tchem LDL-associated phospholipase A2 (1338 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LIPC Tchem Hepatic lipase (436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FASN Tchem Fatty acid synthase (3390 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CEL Tchem Cholesterol esterase (33 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1I2 Tchem Pregnane X receptor (6667 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNCaP (8286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-435 (38290 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MGLL Tchem Monoglyceride lipase (1909 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PSMB2 Tclin Proteasome Macropain subunit (1025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PSMB5 Tclin Proteasome Macropain subunit MB1 (2451 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Faah Anandamide amidohydrolase (3907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Giardia intestinalis (1290 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PRE7 Proteasome component C5 (37 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pla2g7 Platelet-activating factor acetylhydrolase (22 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tpp2 Tripeptidyl-peptidase 2 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abhd16a Protein BAT5 (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abhd6 Monoacylglycerol lipase ABHD6 (221 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PNLIP Pancreatic triacylglycerol lipase (476 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LIPF Gastric triacylglycerol lipase (84 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POSSIBLE LYSOPHOSPHOLIPASE (22 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CUT1 Cutinase 1 (30 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chikungunya virus (1339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abhd16a Phosphatidylserine lipase ABHD16A (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

17 results found

Lot NumberCertificate TypeDateItem
I2205042Certificate of AnalysisJun 15, 2026 O159936
I2205041Certificate of AnalysisJun 15, 2026 O159936
I2205040Certificate of AnalysisJun 15, 2026 O159936
I2205039Certificate of AnalysisJun 15, 2026 O159936
I2205038Certificate of AnalysisJun 15, 2026 O159936
G2530057Certificate of AnalysisAug 05, 2025 O159936
F1715057Certificate of AnalysisJan 07, 2025 O159936
G2523026Certificate of AnalysisJul 15, 2022 O159936
L2509132Certificate of AnalysisJul 15, 2022 O159936
L2420207Certificate of AnalysisJul 15, 2022 O159936
A2508079Certificate of AnalysisJul 15, 2022 O159936
G2507125Certificate of AnalysisJul 15, 2022 O159936
F2603056Certificate of AnalysisJul 15, 2022 O159936
D2614010Certificate of AnalysisJul 15, 2022 O159936
B2627173Certificate of AnalysisJul 15, 2022 O159936
B2521048Certificate of AnalysisJul 15, 2022 O159936
G2106197Certificate of AnalysisMar 11, 2021 O159936

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Chemical and Physical Properties
SolubilitySoluble in DMSO (19 mg/mL), ethanol (20 mg/mL), and DMF (20 mg/mL).
Sensitivityheat sensitive
Specific Rotation[α]-35° (C=1,CHCl3)
Melt Point(°C)43-47°C
Molecular Weight495.700 g/mol
XLogP310.000
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count23
Exact Mass495.392 Da
Monoisotopic Mass495.392 Da
Topological Polar Surface Area81.700 Ų
Heavy Atom Count35
Formal Charge0
Complexity579.000
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Wenjing Jiang, Qun Huang, Xiangxing Meng, Rizwan-ur Rehman, Kun Qian, Xu Yang, Xiaozhi Liu, Jingnan Chen, Ye Zhang, Jing Li, Jilite Wang, Qingbin Guo, Suwen Liu, Hao Wang.  (2023)  Ursolic Acid Inhibited Cholesterol Esterase and Pancreatic Lipase Activities and Decreased Micellar Cholesterol Solubility In Vitro.  JOURNAL OF FOOD BIOCHEMISTRY,      [PMID:] [10.1155/2023/6637700]
2. Sihua Quan, Mengyi Wen, Ping Xu, Chu Chu, Hui Zhang, Kai Yang, Shengqiang Tong.  (2023)  Efficient screening of pancreatic lipase inhibitors from Rheum palmatum by affinity ultrafiltration–high-performance liquid chromatography combined with high-resolution inhibition profiling.  PHYTOCHEMICAL ANALYSIS,      [PMID:38053479] [10.1002/pca.3311]
3. Mei Dong, Cheng Zhao, Yongfang Huang, Ke Zheng, Guanhu Bao, Fenglin Hu, Fan Peng, Mingjun Chen, Zengzhi Li, Ruili Lu.  (2023)  Metabolites analysis and new bioactive compounds from the medicine food homology product of Cordyceps chanhua on artificial media.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:37801798] [10.1016/j.jpba.2023.115749]
4. Dan Yang, Xin-yu-yao Ding, Hai-Xia Xu, Yu-Xian Guo, Qing-Feng Zhang.  (2023)  Chemical profile of Roselle extract and its inhibitory activities on three digestive enzymes in vitro and in vivo.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:37714233] [10.1016/j.ijbiomac.2023.126902]
5. Wen Li, Xinyue Cui, Zilin Chen.  (2023)  The screening of lipase inhibitors based on the metal-organic framework Zeolitic Imidazolate Framework-8-immobilized enzyme microreactor.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:37531848] [10.1016/j.chroma.2023.464257]
6. Suwen Liu, Wenhong Jiang, Chang Liu, Shuo Guo, Hao Wang, Xuedong Chang.  (2023)  Chinese chestnut shell polyphenol extract regulates the JAK2/STAT3 pathway to alleviate high-fat diet-induced, leptin-resistant obesity in mice.  Food & Function,  14  (10): (4807-4823).  [PMID:37128963] [10.1039/D3FO00604B]
7. Xiang Li, Rongxia Li, Xueyu Wang, Xinying Zhang, Zhiyi Xiao, Haibo Wang, Wenhui Sun, Hao Yang, Peng Yu, Qing Hu, Qinghui Guo, Hua Sun.  (2023)  Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:37099836] [10.1016/j.ejmech.2023.115391]
8. Xinyue Zhang, Dan Li, Kexin Wang, Jiao Xie, Yaojie Liu, Tianxin Wang, Suwen Liu, Qun Huang, Qingbin Guo, Hao Wang.  (2023)  Hyperoside inhibits pancreatic lipase activity in vitro and reduces fat accumulation in vivo.  Food & Function,  14  (10): (4763-4776).  [PMID:37128768] [10.1039/D2FO03219H]
9. Jinpeng Liu, Mashooq Khan, Yong Wei, Anna Liu, Tao Wang, Qiongzheng Hu, Li Yu.  (2023)  High-throughput screening of lipase inhibitors as anti-obesity drugs on liquid crystal-infused porous surfaces.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2023.133837]
10. Tao Gao, Shuang Liu, Huang-yang Luo, Ren Wu, Rui Yan, Ling-zhi He, Qing-yu Nie, Hua-li Tang, Guiju Sun.  (2023)  Purification, structural identification, antioxidant activity, and inhibitory effects on digestive enzymes of α-glucan from Chuanminshen violaceum.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2023.105536]
11. Olaoye Solomon Balogun, Anthonia Olufunke Oluduro, Zhiqiang Liu.  (2023)  Chemical composition and in vitro biological studies of volatile oils from Nigerian bee propolis.  JOURNAL OF APICULTURAL RESEARCH,      [PMID:] [10.1080/00218839.2020.1862392]
12. Liyuan Ran, Jinhui Yu, Rui Ma, Qing Yao, Mingjie Wang, Yuping Bi, Zichao Yu, Yingjie Wu.  (2022)  Microalgae oil from Schizochytrium sp. alleviates obesity and modulates gut microbiota in high-fat diet-fed mice.  Food & Function,  13  (24): (12799-12813).  [PMID:36421064] [10.1039/D2FO01772E]
13. Lan Wei, Jingjing Li, Yun Yang, Mei Zhu, Mengke Zhao, Jianhua Yang, Zhiyun Yang, Luyao Zhou, Shenyue Zhou, Jiajia Gong, Xiaogang Jiang, Jiangyun Liu, Yali Li, Jian Zhang.  (2022)  Characterization and potential bioactivity of polyphenols of Rosa rugosa.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2022.102108]
14. Fu-Qin He, Guang-Zhen Wan, Juan Chen.  (2022)  Pancreatic lipase and alpha-glucosidase inhibitors screening from Schisandra chinensis based on spectrum-effect relationship and ultra-high-performance liquid chromatography-tandem mass spectrometry.  JOURNAL OF SEPARATION SCIENCE,  45  (23): (4198-4208).  [PMID:36189874] [10.1002/jssc.202200541]
15. Qing Zhang, Yue Zhou, Xingyu Feng, Yuan Gao, Chengzhi Huang, Xueqing Yao.  (2022)  Low-dose orlistat promotes the therapeutic effect of oxaliplatin in colorectal cancer.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:36017794] [10.1016/j.biopha.2022.113426]
16. Jian-Feng Zhou, Wen-Jun Wang, Zhong-Ping Yin, Guo-Dong Zheng, Ji-Guang Chen, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang.  (2021)  Quercetin is a promising pancreatic lipase inhibitor in reducing fat absorption in vivo.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2021.101248]
17. Ying Li, Bo Chen, Hai-Yan Cao, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang.  (2021)  Pancreatic lipase inhibitory activity of Bambusa multiplex cv. Fernleaf leaf extract in vitro and in vivo.  Food & Function,  12  (16): (7440-7447).  [PMID:34195734] [10.1039/D1FO01168E]
18. Jinhong Wu, Qiaoyu Wu, Danlu Yang, Mi Zhou, Jingshen Xu, Qing Wen, Yan Cui, Yalong Bai, Shannan Xu, Zhengwu Wang, Shaoyun Wang.  (2020)  Patatin primary structural properties and effects on lipid metabolism.  FOOD CHEMISTRY,      [PMID:33272761] [10.1016/j.foodchem.2020.128661]
19. Halah Aalim, Di Wang, Zisheng Luo.  (2020)  Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.  FOOD RESEARCH INTERNATIONAL,      [PMID:33641947] [10.1016/j.foodres.2020.109898]
20. Cong Zhang, Lei Sheng, Ming Yuan, Junjie Hu, Yan Meng, Yong Wu, Liang Chen, Huifan Yu, Shan Li, Guohua Zheng, Zhenpeng Qiu.  (2020)  Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met.  TOXICOLOGY AND APPLIED PHARMACOLOGY,      [PMID:32045588] [10.1016/j.taap.2020.114918]
21. Hang Su, Yi-Ting Ruan, Ying Li, Ji-Guang Chen, Zhong-Ping Yin, Qing-Feng Zhang.  (2020)  In vitro and in vivo inhibitory activity of taxifolin on three digestive enzymes.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:32035149] [10.1016/j.ijbiomac.2020.02.027]
22. Yixia Tang, Wang Li, Yuying Wang, Yuefen Zhang, Yibing Ji.  (2019)  Rapid on-line system for preliminary screening of lipase inhibitors from natural products by integrating capillary electrophoresis with immobilized enzyme microreactor.  JOURNAL OF SEPARATION SCIENCE,  43  (5): (1003-1010).  [PMID:31845470] [10.1002/jssc.201900523]
23. Xinlin Chen, Shang Xue, Yaolan Lin, Jianguang Luo, Lingyi Kong.  (2019)  Immobilization of porcine pancreatic lipase onto a metal-organic framework, PPL@MOF: A new platform for efficient ligand discovery from natural herbs.  ANALYTICA CHIMICA ACTA,      [PMID:31986282] [10.1016/j.aca.2019.11.042]
24. Shangyong Li, Ningning He, Linna Wang.  (2019)  Efficiently Anti-Obesity Effects of Unsaturated Alginate Oligosaccharides (UAOS) in High-Fat Diet (HFD)-Fed Mice.  Marine Drugs,  17  (9): (540).  [PMID:31533255] [10.3390/md17090540]
25. Zhang Yu-Xue, Jiang Zhe-Yue, Han Si-Lan, Li Ling-Yu, Qiao Fang, Zhang Mei-Ling, Du Zhen-Yu.  (2019)  Inhibition of intestinal lipases alleviates the adverse effects caused by high-fat diet in Nile tilapia.  FISH PHYSIOLOGY AND BIOCHEMISTRY,  46  (1): (111-123).  [PMID:31520202] [10.1007/s10695-019-00701-x]
26. Halah Aalim, Tarun Belwal, Lei Jiang, Hao Huang, Xianghe Meng, Zisheng Luo.  (2019)  Extraction optimization, antidiabetic and antiglycation potentials of aqueous glycerol extract from rice (Oryza sativa L.) bran.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2019.01.006]
27. Longyan Zhao, Yujing Qin, Ruowei Guan, Wenqi Zheng, Jikai Liu, Jinhua Zhao.  (2018)  Digestibility of fucosylated glycosaminoglycan from sea cucumber and its effects on digestive enzymes under simulated salivary and gastrointestinal conditions.  CARBOHYDRATE POLYMERS,      [PMID:29455981] [10.1016/j.carbpol.2018.01.029]
28. Xiaonan Zhang, Yan Huang, Siyi Huang, Wenyi Xie, Wenxuan Huang, Yi Chen, Qiyuan Li, Fajian Zeng, Xiongjun Liu.  (2024)  Antisolvent precipitation for the synergistic preparation of ultrafine particles of nobiletin under ultrasonication-homogenization and evaluation of the inhibitory effects of α-glucosidase and porcine pancreatic lipase in vitro.  ULTRASONICS SONOCHEMISTRY,      [PMID:38564909] [10.1016/j.ultsonch.2024.106865]
29. Tiefeng Yuan, Liping Wang, Linzhou Chen, Jinjian Zhong, Yuyang Lin, Yihan Wang, Chen Lin, Huajun Fan.  (2024)  Combinatorial preparation and structural characterization of anthocyanins and aglycones from Purple-heart Radish for evaluation of physicochemical stability and pancreatic lipase inhibitory activity.  FOOD CHEMISTRY,      [PMID:38412808] [10.1016/j.foodchem.2024.138832]
30. Chongyang Mu, Mashooq Khan, Jinpeng Liu, Xinfeng Dong, Zhengtong Wang, Ping Song, Qiongzheng Hu, Li Yu.  (2024)  Development of surface droplet evaporation-based sensing platform for screening lipase inhibitors.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.111256]
31. Jiao Li, Chao-Feng Qin, Nai-Dong Chen.  (2024)  Evaluation of antioxidant, antidiabetic and antiobesity potential of phenylpropanoids (PPs): Structure-activity relationship and insight into action mechanisms against dual digestive enzymes by comprehensive technologies.  BIOORGANIC CHEMISTRY,      [PMID:38507999] [10.1016/j.bioorg.2024.107290]
32. Shan Li, Ronghua Guo, Xiang Gao, Yin Wang, Jiaxin Wen, Ting Zhao, Xiaofei Guo, Junhui Li, Shiguo Chen, Duo Li.  (2024)  Fucosylated chondroitin sulfate alleviates diet-induced obesity by modulating intestinal lipid metabolism and colonic microflora.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39521224] [10.1016/j.ijbiomac.2024.137371]
33. Jun Dai, Zihan Liu, Lei Ma, Chunliu Yang, Ligai Bai, Dandan Han, Qi Song, Hongyuan Yan, Zhiqiang Wang.  (2024)  Identification of procyanidins as α-glucosidase inhibitors, pancreatic lipase inhibitors, and antioxidants from the bark of Cinnamomum cassia by multi-bioactivity-labeled molecular networking.  FOOD RESEARCH INTERNATIONAL,      [PMID:39147522] [10.1016/j.foodres.2024.114833]
34. Hai-Xia Xu, Qiao-Ting Xu, Zhong-Ping Yin, Ji-Guang Chen, Qing-Feng Zhang.  (2024)  Inhibitory activity of luteolin on α-glucosidase and pancreatic lipase in vitro and in vivo.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1111/ijfs.17115]
35. Yangfei Wei, Tao Chen, Hai Song, Shuo Wang, Cheng Shen, Xiaojun Wang, Yulin Li, Junke Wang.  (2024)  Rapidly screening of pancreatic lipase inhibitors from Clematis tangutica using affinity ultrafiltration-HPLC-QTOFMS technique combined with targeted separation, in vitro validation, and molecular docking.  PHYTOCHEMICAL ANALYSIS,      [PMID:39009466] [10.1002/pca.3422]
36. Xiaonan Zhang, Xiaocheng Zhuang, Manxin Chen, Jingrong Wang, Zhuoyu Liu, Daxiong Qiu, Jinna Wang, Yan Huang, Weina Li, Zhiwei Liu.  (2024)  Tannin Acid/Fe3+ Composite Film Filled with Essential Oil Extracted from Melaleuca bracteata F. Muell Leaves for the Preservation of Mango.  CHEMISTRY & BIODIVERSITY,      [PMID:39530337] [10.1002/cbdv.202402221]
37. Zhihua Ni, Xinling Tian, Wenbo Zhao, Wenkai Hu, Jinghua Lv, Xiaoli Sun, Yajie Zhang, Yiwen Zhang, Yuming Zhang, Baoku Li, Fengsong Liu.  (2024)  The detrimental effects and mechanisms of Orlistat in disrupting energy homeostasis and reproduction in Daphnia magna.  AQUATIC TOXICOLOGY,      [PMID:39657302] [10.1016/j.aquatox.2024.107201]
38. Yi-Ting Chen, Peng-Tai Long, Hai-Xia Xu, Wen-Jun Wang, Qing-Feng Zhang.  (2024)  The inhibitory activity of Flos Sophorae Immaturus extract and its major flavonoid components on pancreatic lipase.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39059523] [10.1016/j.ijbiomac.2024.134092]
39. Jiacheng Fang, Peng Jiang, Xincen Wang, Zhongshi Qi, Xin He, Lei Chen, Yurong Guo, Xiaoyun Xu, Run Liu, Duo Li.  (2024)  Thinned young apple powder prevents obesity-induced neuronal apoptosis via improving mitochondrial function of cerebral cortex in mice.  JOURNAL OF NUTRITIONAL BIOCHEMISTRY,      [PMID:38266689] [10.1016/j.jnutbio.2024.109588]
40. Xinjian Bi, Yu Gao, Shiyu Wen, Ziyi Chen, Tong Wu, Jiaqi Wang, Yanmei Hou, Xiaoyu Peng, Wei Li, Lina Pan, Li Wen.  (2024)  Unveiling the Potential Bioactive Peptides Derived From Goat Casein Hydrolysates Based on In Silico Analyses.  Peptide Science,      [PMID:] [10.1002/pep2.24383]
41. Jiaxin Wang, Jinlong Tian, Qilin Tian, Dongnan Li, Ningxuan Gao, Xuefeng Yang, Liang Wang, Ying He, Bin Li, Li Wang.  (2025)  Metabolomic insights into antioxidant properties of blueberry (Vaccinium croymbosum) leaves and a preliminary exploration of their in vitro lipid-lowering activity.  FOOD CHEMISTRY,      [PMID:40934773] [10.1016/j.foodchem.2025.146200]
42. Qianyu Wu, Yu Zhang, Ce Sun, Jun Dang.  (2025)  Online bioactivity-guided HPLC-lipoprotein lipase system with medium-high pressure chromatography for rapid recognition and targeted isolation of natural affinity agents from Nitraria tangutorum.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:40972433] [10.1016/j.chroma.2025.466384]
43. Yu Chang, Bowei Zhang, Yuze Jia, Xiaolu Shi, Yingshuang Lu, Fan Wei, Yunhui Zhang, Huan Lv, Lu Dong, Yan Zhang, Xiangwei Tang, Shuo Wang.  (2025)  Effects of dietary polyphenols addition and oxygen concentration on digestion and absorption of fat in roast beef patties.  FOOD CHEMISTRY,      [PMID:40222130] [10.1016/j.foodchem.2025.144280]
44. Kai Yu, Wenjing Jiang, Ningning Cheng, Baorui Li, Jiao Xie, Aizhen Zong, Ye Zhang, Hao Wang.  (2025)  Molecular mechanisms of naringin's high lipid-lowering activity: pancreatic lipase inhibition and fat accumulation reduction.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,      [PMID:40329900] [10.1002/jsfa.14336]
45. Shan Zhao, Qiyan Huang, Yiran Wang, Yujing Wang, Wenyu Wang, BenxuYang, Aiguo Feng, Chao Li, Shufen Wu, Changlu Wang.  (2025)  Study on the inhibitory effect and mechanism of Monascus yellow pigments (ankaflavin and monascinon) on porcine pancreatic lipase.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2025.128884]
46. Ying Li, Yu Zhang, Li Zhang, Jun Dang.  (2025)  Bioactivity-guided isolation of pancreatic lipase inhibitors from Lycium ruthenicum using a novel HPLC-FLD/pancreatic lipase online recognition system.  FOOD CHEMISTRY,      [PMID:41223526] [10.1016/j.foodchem.2025.147031]
47. Shiyu Li, Li Zhang, Haihua Zhang, Fang Yang, Jun Dang.  (2026)  Online HPLC-FLD recognition system drives activity-guided progressive separation to discover pancreatic lipase inhibitors from Sinacalia tangutica.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2026.116914]
48. Jingpin Gao, Mingxin Jiang, Jianlin Chen, Hongbo Zhang.  (2026)  Orlistat Impairs Chlamydia Trachomatis Development by Disrupting Its Developmental Cycle.  MICROBIAL PATHOGENESIS,      [PMID:41529804] [10.1016/j.micpath.2026.108301]
49. Shi-Hui Lu, Xiu-Xia Li, Xiao-Yan Xia, Wei-Neng Li, Kai-Jie Luo, Jing Huang.  (2026)  Three New Glycosides from the Leaves of Ligustrum robustum and Their Antioxidant Activities and Inhibitory Effects on Fatty Acid Synthase, α-Glucosidase, and α-Amylase.  CHEMISTRY & BIODIVERSITY,  23  (1): (e03315).  [PMID:41494995] [10.1002/cbdv.202503315]
50. Qingfeng Guo, Xia Zhang, Hao Zhang, Mengxue Wang, Haoran Zhou, Meiru Chen, Zhenhua Yin, Juanjuan Zhang, Baocheng Yang, Li Wang, Lin Chen.  (2026)  α-Glucosidase and Pancreatic Lipase Inhibitory Activity of Chemical Constituents from Adzuki Bean (Vigna angularis).  Life-Basel,  16  (2): (235).  [PMID:41752872] [10.3390/life16020235]
51. Liru Ma, Zhen Feng, Chao Zhang, Haode Chang, Wenjing Zhang, Quanmiao Zhang, Yihong Bao, Chunhe Gu.  (2026)  Impact of ripening on the distribution of jackfruit polyphenol fractions and their inhibitory activities against metabolic enzymes.  Food Chemistry-X,      [PMID:] [10.1016/j.fochx.2026.103707]
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