Temozolomide - Moligand™, ≥98%(HPLC) , DNA inhibitor, CAS No.85622-93-1, DNA inhibitor

CAS: 85622-93-1 Cat. No.: T127425 Molecular Weight: 194.15 EC Number: 630-358-9 PubChem CID: 5394
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
Synonyms
4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide | CCRG 81045 | NSC 362856 | TMZ | 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide | 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one | TZM
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
250mg
T127425-250mg
3
$9.90
500mg
T127425-500mg
3
$10.90
1g
T127425-1g
3

$16.90

$25.90
Save $9.00 (34.75%)
5g
T127425-5g
3

$42.90

$64.90
Save $22.00 (33.90%)
25g
T127425-25g
3

$133.90

$200.90
Save $67.00 (33.35%)
100g
T127425-100g
2
$1,029.90
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Moligand™, ≥98%(HPLC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 43 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Temozolomide is a DNA damage inducer.
An apoptosis inducer which causes arrest at the G2/M cell cycle checkpoint.

Specifications

Synonyms
4-methyl-5-oxo-2, 3, 4, 6, 8-pentazabicyclo[4.3.0]nona-2, 7, 9-triene-9-carboxamide | CCRG 81045 | NSC 362856 | TMZ | 3, 4-Dihydro-3-methyl-4-oxoimidazo[5, 1-d][1, 2, 3, 5]tetrazine-8-carboxamide | 8-Carbamoyl-3-methylimidazo[5, 1-d]-1, 2, 3, 5-tetrazin-4(3H)-one | TZM
Specifications & Purity
Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms
enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of temozolomide. Furthermore, temozolomide has been implicated in causing arrest at the G2/M cell cycle checkpoint,
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
DNA inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥98%(HPLC)
Product Properties
ALogP-1.1
Names and Identifiers
Pubchem Sid504750883
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504750883
Canonical SmilesCN1C(=O)N2C=NC(=C2N=N1)C(=O)N
IUPAC Name3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
InChIKeyBPEGJWRSRHCHSN-UHFFFAOYSA-N
INCHI1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
Isomeric SMILES CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
WGK Germany 3
RTECS NJ5927050
PubChem CID 5394
Molecular Weight 194.15
Reaxy-Rn 5547136

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassImidazotetrazines
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentImidazotetrazines
Alternative Parents 2-heteroaryl carboxamides  Carbonylimidazoles  Tetrazines  N-substituted imidazoles  Vinylogous amides  Heteroaromatic compounds  Primary carboxylic acid amides  Azacyclic compounds  Organopnictogen compounds  Organooxygen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Imidazotetrazine - 2-heteroaryl carboxamide - Imidazole-4-carbonyl group - N-substituted imidazole - Tetrazine - Azole - Imidazole - Heteroaromatic compound - Vinylogous amide - Carboxamide group - Primary carboxylic acid amide - Carboxylic acid derivative - Azacycle - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as imidazotetrazines. These are organic polycyclic compounds containing an imidazole ring fused to a tetrazine ring. Imidazole is 5-membered ring consisting of three carbon atoms, and two nitrogen centers at the 1- and 3-positions. Tetrazine is a six-membered aromatic heterocycle made up of four nitrogen atoms and a two carbon atoms.
External Descriptors monocarboxylic acid amide - triazene derivative - imidazotetrazine
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCGR Tclin Glucagon receptor (2563 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Htr7 Serotonin 7 (5-HT7) receptor (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDCK (10148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TLX-5 (157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C6 (2371 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RG2 (196 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16-F10 (4610 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Blood brain barrier (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GL261 (68 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

31 results found

Lot NumberCertificate TypeDateItem
J2227785Certificate of AnalysisMay 11, 2026 T127425
J2227766Certificate of AnalysisMay 11, 2026 T127425
J2227749Certificate of AnalysisMay 11, 2026 T127425
J2227698Certificate of AnalysisMay 11, 2026 T127425
J2227652Certificate of AnalysisMay 11, 2026 T127425
F2217267Certificate of AnalysisJan 26, 2026 T127425
A2408039Certificate of AnalysisOct 13, 2025 T127425
I2516494Certificate of AnalysisAug 15, 2025 T127425
I2516513Certificate of AnalysisAug 15, 2025 T127425
I2516514Certificate of AnalysisAug 15, 2025 T127425
I2516515Certificate of AnalysisAug 15, 2025 T127425
D2507783Certificate of AnalysisMar 20, 2025 T127425
D2507784Certificate of AnalysisMar 20, 2025 T127425
D2507790Certificate of AnalysisMar 20, 2025 T127425
D2522521Certificate of AnalysisMar 20, 2025 T127425
I2412042Certificate of AnalysisSep 21, 2024 T127425
I2412043Certificate of AnalysisSep 18, 2024 T127425
B2508110Certificate of AnalysisSep 04, 2024 T127425
J2410762Certificate of AnalysisSep 04, 2024 T127425
J2410763Certificate of AnalysisSep 04, 2024 T127425
J2410764Certificate of AnalysisSep 04, 2024 T127425
J2410761Certificate of AnalysisSep 04, 2024 T127425
D2408191Certificate of AnalysisMar 22, 2024 T127425
I1817142Certificate of AnalysisFeb 26, 2024 T127425
K2130076Certificate of AnalysisSep 15, 2023 T127425
K2130077Certificate of AnalysisSep 15, 2023 T127425
K2130078Certificate of AnalysisSep 15, 2023 T127425
K2130080Certificate of AnalysisSep 15, 2023 T127425
J2227772Certificate of AnalysisJul 21, 2022 T127425
D2409062Certificate of AnalysisJul 21, 2022 T127425
C2221050Certificate of AnalysisMar 24, 2022 T127425

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Chemical and Physical Properties
SolubilitySoluble in water (5 mg/ml at 25 °C), DMSO (39 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
SensitivityHeat sensitive
Melt Point(°C)206 °C(dec.)
Molecular Weight194.150 g/mol
XLogP3-1.100
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass194.055 Da
Monoisotopic Mass194.055 Da
Topological Polar Surface Area106.000 Ų
Heavy Atom Count14
Formal Charge0
Complexity315.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Yechun Jiang, Yu Jin, Chengcheng Feng, Yayun Wu, Weinan Zhang, Liang Xiao, Zhaoyou Chu, Benjin Chen, Yan Ma, Haisheng Qian, Lingling Xu.  (2023)  Engineering Hyaluronic Acid Microneedles Loaded with Mn2+ and Temozolomide for Topical Precision Therapy of Melanoma.  Advanced Healthcare Materials,      [PMID:38112062] [10.1002/adhm.202303215]
2. Li Yatian, Gao Zhenyue, Wang Yuhong, Pang Bo, Zhang Binbin, Hu Ruxin, Wang Yuqing, Liu Chao, Zhang Xuebin, Yang Jingxuan, Mei Mei, Wang Yongzhi, Zhou Xuan, Li Min, Ren Yu.  (2023)  Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma.  Nature Communications,  14  (1): (1-19).  [PMID:37429858] [10.1038/s41467-023-39845-z]
3. Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang.  (2023)  Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting.  JOURNAL OF LIPOSOME RESEARCH,      [PMID:36974836] [10.1080/08982104.2023.2191718]
4. Hou Xiaoying, Du Hongzhi, Deng Yufei, Wang Haiping, Liu Jinmi, Qiao Jialu, Liu Wei, Shu Xiji, Sun Binlian, Liu Yuchen.  (2023)  Gut microbiota mediated the individualized efficacy of Temozolomide via immunomodulation in glioma.  Journal of Translational Medicine,  21  (1): (1-15).  [PMID:36927689] [10.1186/s12967-023-04042-5]
5. Xiaoyi Shi, Meng Li, Qiming Huang, Liuming Xie, Zhibing Huang.  (2023)  Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways.  ACS Chemical Neuroscience,      [PMID:36917811] [10.1021/acschemneuro.3c00104]
6. Su Jie, Yin Wei, Huo Mengmeng, Yao Qing, Ding Liqiong.  (2023)  Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,  396  (6): (1247-1255).  [PMID:36715733] [10.1007/s00210-023-02384-x]
7. Zhou Songlei, Huang Yukun, Chen Yu, Liu Yipu, Xie Laozhi, You Yang, Tong Shiqiang, Xu Jianpei, Jiang Gan, Song Qingxiang, Mei Ni, Ma Fenfen, Gao Xiaoling, Chen Hongzhuan, Chen Jun.  (2023)  Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma.  Nature Communications,  14  (1): (1-20).  [PMID:36702831] [10.1038/s41467-023-35957-8]
8. Chen Bo, Li Xiaoli, Wu Lihong, Zhou Duanfang, Song Yi, Zhang Limei, Wu Qiuya, He Qichen, Wang Gang, Liu Xu, Hu Hui, Zhou Weiying.  (2022)  Quercetin Suppresses Human Glioblastoma Migration and Invasion via GSK3β/β-catenin/ZEB1 Signaling Pathway.  Frontiers in Pharmacology,      [PMID:36386155] [10.3389/fphar.2022.963614]
9. Hu Keqi, Zhou Daquan, Rao Linlin, Wang Peng, Xiang Chunxiang, Chen Feng.  (2021)  A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System.  Frontiers in Bioengineering and Biotechnology,      [PMID:34820365] [10.3389/fbioe.2021.766470]
10. Mingming Sun, Hao Sheng, Tingfeng Wu, Jiaqi Song, Huanran Sun, Yingzhi Wang, Jiyan Wang, Zhen Li, Huifang Zhao, Junzhen Tan, Yanping Li, Guo Chen, Qingrong Huang, Yuan Zhang, Bei Lan, Shuangping Liu, Changliang Shan, Shuai Zhang.  (2021)  PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.  BIOCHEMICAL PHARMACOLOGY,      [PMID:34411567] [10.1016/j.bcp.2021.114736]
11. Man Xu, Guangmeng Li, Haoxiang Zhang, Xiaoming Chen, Yi Li, Qianming Yao, Maobin Xie.  (2020)  Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect.  DRUG DELIVERY,      [PMID:32611218] [10.1080/10717544.2020.1785581]
12. Zeng Xiaofan, Wang Qi, Tan Xuan, Jia Le, Li Yuwei, Hu Mingdi, Zhang Zhijie, Bai Xicheng, Zhu Yanhong, Yang Xiangliang.  (2019)  Mild thermotherapy and hyperbaric oxygen enhance sensitivity of TMZ/PSi nanoparticles via decreasing the stemness in glioma.  JOURNAL OF NANOBIOTECHNOLOGY,  17  (1): (1-12).  [PMID:30935403] [10.1186/s12951-019-0483-1]
13. Yuanyuan Xie, Xiaofan Zeng, Xian Wu, Jun Hu, Yanhong Zhu, Xiangliang Yang.  (2018)  Hyperbaric oxygen as an adjuvant to temozolomide nanoparticle inhibits glioma growth by inducing G2/M phase arrest.  Nanomedicine,      [PMID:29473458] [10.2217/nnm-2017-0395]
14. Bin Du, Changqing Hong, Xinghong Zhang, Jiazhi Wang, Qiang Qu.  (2018)  Preparation and mechanical behaviors of SiOC-modified carbon-bonded carbon fiber composite with in-situ growth of three-dimensional SiC nanowires.  JOURNAL OF THE EUROPEAN CERAMIC SOCIETY,      [PMID:] [10.1016/j.jeurceramsoc.2018.01.002]
15. Yao‑Dong Chen, Yu Zhang, Tian‑Xiu Dong, Yu‑Tong Xu, Wei Zhang, Ting‑Ting An, Peng‑Fei Liu, Xiu‑Hua Yang.  (2017)  Hyperthermia with different temperatures inhibits proliferation and promotes apoptosis through the EGFR/STAT3 pathway in C6 rat glioma cells.  Molecular Medicine Reports,  16  (6): (9401-9408).  [PMID:29039593] [10.3892/mmr.2017.7769]
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