β-Nicotinamide Mononucleotide (NMN) - ≥95% , CAS No.1094-61-7

CAS: 1094-61-7 Cat. No.: N131850 Molecular Weight: 334.22 Beilstein Registry Number: 3570187 EC Number: 214-136-5

GRADE & PURITY ≥95%

Synonyms

nicotinamide ribonucleotide | NMN zwitterion | beta-Nicotinamide mononucleotide | Nicotinamide ribotide | nicotinamide D-ribonucleotide | nicotinamide mononucleotide | beta-nicotinamide D-ribonucleotide | beta-NMN | nicotinamide nucleotide | NMN

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

A product of the eNAMPT reaction and a NAD+ intermediate

β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.

β-Nicotinamide mononucleotide is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Specifications

Synonyms

nicotinamide ribonucleotide | NMN zwitterion | beta-Nicotinamide mononucleotide | Nicotinamide ribotide | nicotinamide D-ribonucleotide | nicotinamide mononucleotide | beta-nicotinamide D-ribonucleotide | beta-NMN | nicotinamide nucleotide | NMN

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Product of the NAMPT reaction and\xa0a key intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD + ). Ameliorates glucose intolerance by restoring NAD + levels in high-fat diet (HFD)-induced T2D mice. Enhances hepatic insulin sensitiv

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

• Pubchem Sid: 488181949
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488181949
• Canonical Smiles: C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)[O-])O)O)C(=O)N
• IUPAC Name: [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
• InChIKey: DAYLJWODMCOQEW-TURQNECASA-N
• INCHI: 1S/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1
• Isomeric SMILES: C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)[O-])O)O)C(=O)N
• WGK Germany: 3
• Molecular Weight: 334.22
• Beilstein: 3570187
• Reaxy-Rn: 40276623
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=40276623&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Class Pyridine nucleotides
      • Subclass Nicotinamide nucleotides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Class: Pyridine nucleotides
• Subclass: Nicotinamide nucleotides
• Intermediate Tree Nodes: Not available
• Direct Parent: Nicotinamide nucleotides
• Alternative Parents: Pentose phosphates Glycosylamines Monosaccharide phosphates Nicotinamides Alkyl phosphates Pyridinium derivatives Vinylogous amides Tetrahydrofurans Heteroaromatic compounds Primary carboxylic acid amides Secondary alcohols 1,2-diols Azacyclic compounds Oxacyclic compounds Organic zwitterions Organic oxides Hydrocarbon derivatives Organonitrogen compounds Organopnictogen compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Nicotinamide-nucleotide - Pentose-5-phosphate - Pentose phosphate - Glycosyl compound - N-glycosyl compound - Pentose monosaccharide - Monosaccharide phosphate - Nicotinamide - Pyridine carboxylic acid or derivatives - Monosaccharide - Organic phosphoric acid derivative - Phosphoric acid ester - Alkyl phosphate - Pyridinium - Pyridine - Heteroaromatic compound - Vinylogous amide - Tetrahydrofuran - 1,2-diol - Carboxamide group - Secondary alcohol - Primary carboxylic acid amide - Azacycle - Oxacycle - Carboxylic acid derivative - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organic zwitterion - Alcohol - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as nicotinamide nucleotides. These are pyridine nucleotides, in which the pyridine base is nicotinamide or a derivative thereof.
• External Descriptors: nicotinamide mononucleotide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

LDHB Tchem L-lactate dehydrogenase B chain (463 Activities)

Discover Target: LDHB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDH1 Tchem Malate dehydrogenase cytoplasmic (119 Activities)

Discover Target: MDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GAPDH Tchem Glyceraldehyde-3-phosphate dehydrogenase liver (1284 Activities)

Discover Target: GAPDH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

GLUD1 Glutamate dehydrogenase (27 Activities)

Discover Target: GLUD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

panE Ketopantoate reductase (28 Activities)

Discover Target: panE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in PBS (10 mg/ml).
• Sensitivity: heat sensitive
• Specific Rotation[α]: -24° (C=2,H2O)
• Melt Point(°C): 166 °C
• Molecular Weight: 334.220 g/mol
• XLogP3: -3.500
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 334.057 Da
• Monoisotopic Mass: 334.057 Da
• Topological Polar Surface Area: 166.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 455.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia.  (2023)  Nicotinamide mononucleotide pretreatment improves long-term isoflurane anesthesia-induced cognitive impairment in mice.  BEHAVIOURAL BRAIN RESEARCH,      [PMID:37931707] [10.1016/j.bbr.2023.114738]

2. Qi Shen, Shi-Jia Zhang, Bin-Hui Xu, Zhi-Yu Chen, Feng Peng, Neng Xiong, Ya-Ping Xue, Yu-Guo Zheng.  (2023)  Semirational engineering of Cytophaga hutchinsonii polyphosphate kinase for developing a cost-effective, robust, and efficient adenosine 5′-triphosphate regeneration system.  APPLIED AND ENVIRONMENTAL MICROBIOLOGY,      [PMID:37902313] [10.1128/aem.01106-23]

3. Ruixue Duan, Yueping Li, Ruru Zhang, Xuelan Hu, Yi wang, Jianfeng Zeng, Mingyuan Gao.  (2023)  Reversing Acute Kidney Injury Through Coordinated Interplay of Anti-inflammation and Iron Supplementation.  ADVANCED MATERIALS,      [PMID:37029662] [10.1002/adma.202301283]

4. Zhuhui Chen, Yue Xiong, Ranran Ma, Pei Chen, Le Duan, Shuying Yang, Ineza Urujeni Gisèle, Linjun You, Deli Xiao.  (2023)  A novel magnetic fluid for ultra-fast and highly efficient extraction of N1-methylnicotinamide in urine samples.  NEW JOURNAL OF CHEMISTRY,  47  (16): (7862-7872).  [PMID:] [10.1039/D3NJ00488K]

5. Wu Yue, Yang Jingjuan, Xu Chengmei, Li Qiuqi, Ma Yage, Zhao Shenglan, Zhuang Jiachen, Shen Fei, Wang Qianqian, Feng Fengqin, Zhang Xi.  (2022)  Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans.  Frontiers in Nutrition,      [PMID:36483922] [10.3389/fnut.2022.1065145]

6. Zhongshi Huang, Ning Li, Shiqin Yu, Weiping Zhang, Tianmeng Zhang, Jingwen Zhou.  (2022)  Systematic Engineering of Escherichia coli for Efficient Production of Nicotinamide Mononucleotide From Nicotinamide.  ACS Synthetic Biology,      [PMID:35977419] [10.1021/acssynbio.2c00100]

7. Jinhui Hu, Ting Wang, Lin Zhou, Shaohua Wei.  (2020)  A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition.  JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,      [PMID:32653858] [10.1016/j.jphotobiol.2020.111955]

8. Zhang Weihong, Wang Dan, Wang Jie-Xin, Pu Yuan, Chen Jian-Feng.  (2020)  High-gravity-assisted emulsification for continuous preparation of waterborne polyurethane nanodispersion with high solids content.  Frontiers of Chemical Science and Engineering,  14  (6): (1087-1099).  [PMID:] [10.1007/s11705-019-1895-z]

9. Guohan Sun, Shiqiao Wang, Jianfeng Zhou, Jianbin Pan, Yanli Tong, Qinghua Mei, Haiyun Zhai.  (2019)  Constructing a simple and sensitive electrochemical sensor for the determination of NMN based on p-m-ABSA film modified glassy carbon electrode.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2019.104438]

10. Dengcheng Huang, Yu Zhou, Yuan Xiang, Meijie Shu, Hongxiang Chen, Bing Yang, Xinghua Liao.  (2018)  Polyurethane/doxorubicin nanoparticles based on electrostatic interactions as pH-sensitive drug delivery carriers.  POLYMER INTERNATIONAL,  67  (9): (1186-1193).  [PMID:] [10.1002/pi.5618]

11. Ma Le, Song Lina, Li Fang, Wang Heng, Liu Baohua.  (2017)  Preparation and properties of poly (propylene carbonate)-based waterborne polyurethane-acrylate composite emulsion.  COLLOID AND POLYMER SCIENCE,  295  (12): (2299-2307).  [PMID:] [10.1007/s00396-017-4198-2]

12. Caideng Yuan, Mengyao Wang, Haitao Li, Zhongwei Wang.  (2017)  Preparation and properties of UV-curable waterborne polyurethane–acrylate emulsion.  JOURNAL OF APPLIED POLYMER SCIENCE,  134  (34): (45208).  [PMID:] [10.1002/app.45208]

13. Di Liu, Guo-Min Wu, Zhen-Wu Kong.  (2016)  Preparation and characterization of a polydimethylsiloxane-modified, epoxy-resin-based polyol dispersion and its crosslinked films.  JOURNAL OF APPLIED POLYMER SCIENCE,  134  (1):   [PMID:] [10.1002/app.44342]

14. Sude Ma, Guolin Song, Ningbo Feng.  (2012)  Preparation and characterization of self-emulsified waterborne nitrocellulose.  CARBOHYDRATE POLYMERS,      [PMID:24750600] [10.1016/j.carbpol.2012.02.029]

15. Jinbang Han, Xiuzhong Zhu, Li Tian, Naishuo Yan, Haitao Zhang, Lei Wang.  (2024)  Bio-based waterborne polyurethanes from castor oil, sorbitan monooleate and sodium lignosulfonate with ultraviolet resistance, photothermal effect, corrosion protection and degradation properties.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39645103] [10.1016/j.ijbiomac.2024.138471]

16. Xin Chen, Jianyan Feng, Shuaishuai Han, Yang Bai, Peng Wang, Haoqiang Liu, Peng Zhang, Xiaomin Luo.  (2024)  Cellulose nanocrystal-modified bio-based aqueous polyurethane coating agent for kraft paper packaging.  JOURNAL OF APPLIED POLYMER SCIENCE,  141  (32): (e55745).  [PMID:] [10.1002/app.55745]

17. Hanqi Yang, Jingdong Peng, Huanjun Peng, Hanlin Zeng, Jiayu Yu, Jiajia Wu, Xiang Wang.  (2024)  Dicationic imidazole ionic liquid stationary phase for preservative detection and its application under mixed mode of HILIC/RPLC/IEC.  ANALYTICA CHIMICA ACTA,      [PMID:38609259] [10.1016/j.aca.2024.342504]

18. Lewen Huang, Yibao Li, Zhong Zheng, Yun Bai, Thomas P. Russell, Changfei He.  (2024)  Flexible, transparent, and sustainable cellulose-based films for organic solar cell substrates.  Materials Horizons,  11  (6): (1560-1566).  [PMID:38263927] [10.1039/D3MH01998E]

19. Jingting Zhang, Fu Chen.  (2024)  Integrated transcriptome and metabolome study reveal the therapeutic effects of nicotinamide riboside and nicotinamide mononucleotide on nonalcoholic fatty liver disease.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:38729053] [10.1016/j.biopha.2024.116701]

20. Yuan Qie, Hailong Hu, Kuibao Yu, Chao Zhong, Songman Ju, Yanbing Liu, Tailiang Guo, Fushan Li.  (2024)  Ligand-Nondestructive Direct Photolithography Assisted by Semiconductor Polymer Cross-Linking for High-Resolution Quantum Dot Light-Emitting Diodes.  NANO LETTERS,      [PMID:38230959] [10.1021/acs.nanolett.3c04230]

21. Yue-Yue Guo, Nan-Nan Liang, Xiao-Yi Zhang, Ya-Hui Ren, Wen-Zheng Wu, Zhi-Bing Liu, Yi-Zhang He, Yi-Hao Zhang, Yi-Chao Huang, Tao Zhang, De-Xiang Xu, Shen Xu.  (2024)  Mitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis.  Redox Biology,      [PMID:38733909] [10.1016/j.redox.2024.103179]

22. Yingjie Du, Xiuyan Luo, Xiaohong Ye, Meijia Song, Yingjia Li, Shumao Yang, Caoxing Huang, Jiandong Cui.  (2025)  Molecular imprinted photoresponse hybrid biocatalyst for ultrasensitive glutamate detection.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40147642] [10.1016/j.ijbiomac.2025.142540]

23. Xinyi Lu, Pingping Jin, Qianyun Tang, Min Zhou, Hanjie Xu, Chen Su, Lei Wang, Feng Xu, Min Zhao, Yongxiang Yin, Jinqiu Zhang, Zhen Jia, Xinrui Peng, Jie Zhou, Lu Wang, Yan Chen, Min Wang, Min Yang, Daozhen Chen, Yu Chen.  (2025)  NAD+ Metabolism Reprogramming Drives SIRT1-Dependent Deacetylation Inducing PD-L1 Nuclear Localization in Cervical Cancer.  Advanced Science,      [PMID:39988985] [10.1002/advs.202412109]

24. Shuangxi Zhang, Xinlin Wei, Rongbo Wang, Hejing Shen, Hehuan You, Langjun Cui, Yi Qiang, Peiqing Liu, Meixiang Zhang, Yuyan An.  (2024)  Nicotinamide mononucleotide confers broad-spectrum disease resistance in plants.  Journal of Integrative Agriculture,      [PMID:] [10.1016/j.jia.2024.04.027]

25. Zhanbo Sun, Lixian Liu, Hongyuan Liang, Lingyun Zhang.  (2024)  Nicotinamide mononucleotide induces autophagy and ferroptosis via AMPK/mTOR pathway in hepatocellular carcinoma.  MOLECULAR CARCINOGENESIS,      [PMID:38197493] [10.1002/mc.23673]

26. Cao Yu-Ting, Lu Shuai-Wei, Zhou Yu-hang, Wei Jun.  (2024)  Novel organosilicon-modified polyisocyanate crosslinkers for curing of waterborne hydroxyl acrylic resin.  Journal of Coatings Technology and Research,      [PMID:] [10.1007/s11998-024-00927-2]

27. Yu Bai, Chenwei Dai, Nini Chen, Xiuhong Zhou, Hua Li, Qinghua Xu, Yong Xu.  (2024)  Plasma-activated medium exerts tumor-specific inhibitory effect on hepatocellular carcinoma via disruption of the salvage pathway.  JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,  75  (2): (91).  [PMID:39345287] [10.3164/jcbn.23-112]

28. Zhilv Chen, Tao Wang, Chao Li, Mengxiang Fang, Wei Chen, Ximing Hu, Wei Zhang, li Zhang, Wenyang Fan, Shaojuan Zeng.  (2024)  Research on CO2 capture performance of DMEDA water-lean absorbents based on molecular dynamics.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2024.128924]

29. Di Liu, Kang Yang, Liugen Xu, Xiran Shen, Lei Feng, Yangang Jiang, Amjad Ali, Jianwei Lu, Li Guo.  (2024)  Self-Assembly Study of Block Copolypeptoids in Response to pH and Temperature Stimulation.  Polymers,  16  (8): (1082).  [PMID:38675001] [10.3390/polym16081082]

30. Chuanlong Wang, Qingyi Chen, Siyuan Chen, Lijuan Fan, Zhending Gan, Muyang Zhao, Lexuan Shi, Peng Bin, Guan Yang, Xihong Zhou, Wenkai Ren.  (2024)  Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation.  MOLECULAR CELL,      [PMID:38266638] [10.1016/j.molcel.2024.01.002]

31. Zhuolun Li, Yaqiao Wang, Haofan Lu, Yibo Sun, Xiangdong Wang, Shihong Chen.  (2024)  Stable nanoscale sea-island structure of biobased polyamide 56/poly (butylene adipate-co-terephthalate) blends compatibilized by interfacial hyperbranched structure: Toward biobased polymer blends with ultrahigh toughness.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38216014] [10.1016/j.ijbiomac.2024.129310]

32. Meiying Ge, Yonggui Li, Lixin Wu, Ren Liu, Jia-Tao Miao.  (2024)  Structural Design Strategy of a Biobased Allyl Compound with Dynamic Boronic Ester Bonds to Form Rigid-Soft Self-Healing Polymer Networks via Thiol–Ene “Click” Photopolymerization for Integrated Preparation of a Flexible Device.  MACROMOLECULES,      [PMID:] [10.1021/acs.macromol.3c02253]

33. Zhaoyuan Zhang, Jiehu Liu, Meng Wang, Yang Li, Minglei Hou, Jiaren Cao, Jing Wu, Lingqia Su.  (2025)  Systematic modification of high nicotinamide mononucleotide production in Escherichia coli.  JOURNAL OF BIOTECHNOLOGY,      [PMID:40157454] [10.1016/j.jbiotec.2025.03.014]

34. Zhengyi Zhang, Baochen Cheng, Wenqian Du, Mengqi Zeng, Ke He, Tingyi Yin, Sen Shang, Tian Su, Dan Han, Xinyi Gan, Ziyang Wang, Meng Liu, Min Wang, Jiankang Liu, Yan Zheng.  (2024)  The Role of Nicotinamide Mononucleotide Supplementation in Psoriasis Treatment.  Antioxidants,  13  (2): (186).  [PMID:38397784] [10.3390/antiox13020186]

35. Caini Yu, Yanling Peng, Tong Yu, Jia Ke, Qi Jiang, Peirong Li, Renxiang Yuan, Tingting Meng, Fuqiang Hu, Jianwei Wang, Hong Yuan.  (2025)  Dual-Functional Nanoparticles to Reverse Osteoblast Senescence and Enhance Calcium Supplementation for Alleviating Senile Osteoporosis.  Advanced Healthcare Materials,      [PMID:40662226] [10.1002/adhm.202501164]

36. Duan Yuan, Li Jing-Yi, Ding Yong-Bo, Qiao Yong-Luo, Shen Liang, Li Xin-Gui.  (2025)  UV-curable waterborne polyurethane acrylate coatings prepared from bio-based alkyd polyols.  Journal of Coatings Technology and Research,      [PMID:] [10.1007/s11998-025-01108-5]

37. Xiao-Yi Zhang, Yi-Hao Zhang, Nan-Nan Liang, Shan-Shan Xu, Qiang-Sheng Li, Ya-Ping Song, Wei-Wei Zhang, Bo Wang, Hua Wang, Yi-Chao Huang, De-Xiang Xu.  (2025)  The m6A modification-mediated upregulation of ETS2 translation drives arsenic-induced spermatogonial senescence.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:40865778] [10.1016/j.freeradbiomed.2025.08.053]

38. Jiaqi Chang, Fengsen Wang, Peng Zhang, Jiaqi Li, Xi Zhang, Fanhong Chen, Qianrui Lv.  (2025)  Hierarchical porous UIO-66-NH2 derived from ionic liquid enabling sub-second humidity response for respiratory monitoring and non-contact sensing.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2025.138495]

39. lily wang, Fajun Peng, Di Jin, Sen Fang, Yan Wang.  (2025)  Eco-Friendly Fabrication of Hydrophobic and Breathable Nanofibrous Membranes via Molecularly Engineered WPU/PAM Composites.  Nanoscale Advances,      [PMID:40880599] [10.1039/D5NA00467E]

40. Ya-Xin Yao, Xue Lu, Zhao Li, Hao-Yu Liao, Zhi-Bing Liu, Hui Zhao, Hua Wang, De-Xiang Xu, Zhu-Xia Tan.  (2025)  Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice.  TOXICOLOGY AND APPLIED PHARMACOLOGY,      [PMID:40840615] [10.1016/j.taap.2025.117524]

41. Jinbang Han, Xiuzhong Zhu, Li Tian, Naishuo Yan, Jinjie Zang, Haitao Zhang, Lei Wang, Fengshan Zhang.  (2025)  UV-resistant and light-controlled self-healing lignin-based waterborne polyurethane elastomers for photothermal welding.  COMPOSITES PART B-ENGINEERING,      [PMID:] [10.1016/j.compositesb.2025.113001]

42. Seongsu Kang, Jiwon Park, Eunbyul Cho, Dohyun Kim, Sanghyun Ye, Eui Taek Jeong, Seung-Hyun Jun, Nae-Gyu Kang.  (2025)  Distinctive Gene Expression Profiles and Biological Responses of Skin Fibroblasts to Nicotinamide Mononucleotide: Implications for Longevity Effects on Skin.  Biomedicines,  13  (10): (2395).  [PMID:41153679] [10.3390/biomedicines13102395]

43. Xiaoling Xu, Bin Peng, Yanqiu Wang, Yaqi Dong, Hui Wang, Wentong Chen, Yan Liu, Qiang Zhang.  (2024)  Fabrication of POSS-centered polyester network as high anti-chlorine and anti-fouling separation layer of membrane via successive Photo-ATRP and interfacial polymerization for molecular separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2024.123432]

44. Shiyao Guo, Mingyue Zhang, Ke Zhang, Xiaotong Lu, Peiran Chen, Bangliu Yang, Xueqian Wang, Yuhong Zhuo, Dongqin Yu, Chao Qi, Kaiyong Cai.  (2025)  ROS-Responsive Titanium Implant Coatings Enhance Osteoporotic Osseointegration via Microenvironment Remodeling and Mitochondrial Repair.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202524289]

45. Heng Tang, Ke Ning, Boji Wu, Xuhong Wang, Jingyu He, Pingping Li, Lina Pan, Jiawen Zhang, Yi He, Shizhu Bian, Xingyu Ma, Jihang Zhang, Chuan Liu, Zhexue Qin, Houyuan Hu.  (2025)  Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase.  BIOCHEMICAL PHARMACOLOGY,      [PMID:40189160] [10.1016/j.bcp.2025.116932]

46. Hongtao Duan, Rui Zhang, Aiminuer Asikaer, Liang Pan, Shui Wang, Kuilong Huang, Deshuai Lou, Yuanqiang Wang, Zhihua Lin, Yan Shen.  (2025)  Nicotinamide mononucleotide ameliorates hypertriglyceridemia pancreatitis via NAD+/SIRT1-mediated TXNIP suppression and NOTCH pathway for accelerated repair-associated processes.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:40215777] [10.1016/j.intimp.2025.114620]

47. Fengrui Yu, Hongwen Li, Xianglong Li, Jianping Shi, Yanbin Feng, Song Xue.  (2025)  Efficient Conversion of Nicotinamide Mononucleotide Based on Elucidation of the Limitations in Multienzyme Cascade Reactions.  Biotechnology Journal,  20  (2): (e202400707).  [PMID:39989278] [10.1002/biot.202400707]

48. Han Zhou, Qin Chen, Yang You, Yunqi Li, Yaozhu Tian, Haibo Xie.  (2025)  Degradable Eugenol-Derived Poly(thioether carbonate)/Bamboo Powder Thermoset Composite Prepared via Thiol–Ene Click Polymerization.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.5c00477]

49. Yiming Liu, Shanshan Du, Xiangxiang Zhang, Chao Li, Shubin Li, Wenxia Xu, Jingjing Zhao, Wei Mu, Xiaojun Han.  (2025)  Construction of the reduced nicotinamide adenine dinucleotide salvage pathway in artificial cells and its application in amino acid synthesis.  Chemical Science,      [PMID:40529560] [10.1039/D5SC00852B]

50. Yuhan Li, Guangming Huang.  (2025)  Solid-Phase Extraction Coupled to Tandem Mass Spectrometry for Rapid Quantitation of Urinary Catecholamines and Total Metanephrines.  RAPID COMMUNICATIONS IN MASS SPECTROMETRY,  39  (17): (e10077).  [PMID:40462419] [10.1002/rcm.10077]

51. Zhu Ganggui, Li Qiaxuan, Yao Qifeng, Zhao Jin, Ding Shuo, Mai Shixiong, Yue Bingqin, Chen Jingyu, Huang Man.  (2025)  β-Nicotinamide mononucleotide activates the SIRT1/NF-κB pathway to alleviate ischemia reperfusion injury after lung transplantation.  Journal of Translational Medicine,  23  (1): (1349).  [PMID:41291722] [10.1186/s12967-025-07382-6]

52. Yuan Duan, Lingjia Qiu, Mengting Zhang, Yongbo Ding, Peilin Wang, Liang Shen.  (2026)  Eco-friendly solvent-free waterborne hydroxyacrylate dispersions based on bio-based castor oil hyperbranched polyols for two-component polyurethane coatings with damping performance.  PROGRESS IN ORGANIC COATINGS,      [PMID:] [10.1016/j.porgcoat.2026.109961]

53. Shan Sun, Xinger Ning, Xiaoming Guo, Beiwei Zhu.  (2026)  Stabilization of high internal phase emulsions by chitooligosaccharide‑sodium tripolyphosphate complexes: Application in enhancing stability and bioaccessibility of nicotinamide mononucleotide and Antarctic krill oil.  FOOD CHEMISTRY,      [PMID:41734544] [10.1016/j.foodchem.2026.148543]

54. Hangchao Zhang, Jian Fu, Yan Guo, Shijie Liu, Xuehua Mei, Xiu Zeng, Wenkai Ren.  (2026)  The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation.  Cell Chemical Biology,  33  (2): (169-182).  [PMID:41638206] [10.1016/j.chembiol.2026.01.002]

55. Weizuo Liao, Yuxuan Xiao, Qunying Leng, Xinxin Yin, Ziyin Li, Junfeng Deng, Shixiong Zheng, Ruixue Liu, Biao Chen, Shiwei Li, Qiang Niu, Xingfen Yang, Zhini He.  (2026)  Enhanced Sensitivity and Human Relevance: a TNF-α-Induced HaCaT Keratinocyte Model for Screening Anti-Inflammatory Cosmetic Materials.  JOURNAL OF APPLIED TOXICOLOGY,      [PMID:41742400] [10.1002/jat.70120]

56. Wang Yunduan, Li Qiao, Li Yueyue, Ma Zifeng, Xu Hongmei, Chen Kechao, Li Jian, Lan Daoliang, Fu Wei.  (2026)  NMN/NAD+/SIRT1 axis activates NAMPT to ameliorate H2O2-triggered the impairment of progesterone synthesis in ovarian granulosa cells.  Journal of Ovarian Research,      [PMID:41764539] [10.1186/s13048-026-02025-w]