Crospovidone - USP, JP, Ph.Eur., E 1202, NF , CAS No.25249-54-1

CAS: 25249-54-1 Cat. No.: C494178 Formula: (C₆H₉NO)n EC Number: 607-660-4

GRADE & PURITY USP, JP, Ph.Eur., E 1202, NF

Synonyms

Polyvinylpyrrolidone

Storage

Room temperature

Shipped In

Normal

Overview

C494178, Crospovidone, is unsurpassed in its performance and versatility as a superdisintegrant in formulations. 

It combines different mechanisms to achieve rapid tablet disintegration at low concentrations (1-5%). Due to its viscoelasticity, C494178 is highly compactable, resulting in robust tablets with increased tensile strength and reduced friability. Scanning electron microscope images of C494178 show a granular and porous structure with a large surface area. It enhances the dissolution of poorly soluble drug actives and due to its non-ionic property, it does not bear any risk of interaction with cationic APIs. 

C494178 is available in two particle sizes to serve different application requirements. 

Benefits:

1.Rapid disintegration at low concentrations (1-5%)

2.Functions via a combination of disintegration mechanisms (wicking, shape recovery, and swelling), thus imparting its unsurpassed versatility as a 3.superdisintegrant in formulations 

4.Suitability for use in direct compression, wet granulation, and dry granulation 

5.Increased tablet tensile strength and reduced friability due to high compressibility 

6.No gel formation even at higher concentrations (10%) – ideal for ODTs

Product specifications and parameters:

SKU	Average Particle Size by Laser Diffraction [μm]	Compendial Type	Pack Size
C494178-XL-25g	100	A	25g
C494178-XL10-25g	30	B	25g
C494178-XL-100g	100	A	100g
C494178-XL10-100g	30	B	100g
C494178-XL-500g	100	A	500g

Specifications

Synonyms

Polyvinylpyrrolidone

Specifications & Purity

USP, JP, Ph.Eur., E 1202, NF

Storage

Room temperature

Shipped In

Normal

Grade

E 1202, JP, NF, Ph.Eur., USP

Names and Identifiers

• Canonical Smiles: C=CN1CCCC1=O
• IUPAC Name: 1-ethenylpyrrolidin-2-one
• InChIKey: WHNWPMSKXPGLAX-UHFFFAOYSA-N
• INCHI: 1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
• Isomeric SMILES: C=CN1CCCC1=O
• WGK Germany: 1
• Reaxy-Rn: 110513
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=110513&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Pyrrolidines
      • Subclass Pyrrolidones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Pyrrolidines
• Subclass: Pyrrolidones
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrrolidine-2-ones
• Alternative Parents: Tertiary carboxylic acid amides Lactams Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: 2-pyrrolidone - Tertiary carboxylic acid amide - Lactam - Carboxamide group - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrrolidine-2-ones. These are pyrrolidines which bear a C=O group at position 2 of the pyrrolidine ring.
• External Descriptors: pyrrolidin-2-ones

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Moisture sensitive；Heat sensitive
• Melt Point(°C): >300℃
• Molecular Weight: 111.140 g/mol
• XLogP3: 0.400
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 111.068 Da
• Monoisotopic Mass: 111.068 Da
• Topological Polar Surface Area: 20.300 Ų
• Heavy Atom Count: 8
• Formal Charge: 0
• Complexity: 120.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1