Cytochrome P450 2E1 Antibody - Primary antibody, specific to CYP2E1, Rabbit IgG

Cat. No.: Ab098732

GRADE & PURITY Carrier Free, See COA

Application

IHC, WB

Host species

Rabbit

Reactive species

Human, Mouse, Rat

Isotype

Rabbit IgG

Conjugation

Unconjugated

Overview

Rabbit anti Human Cytochrome P450 2E1 Antibody, Polyclonal antibody, could be used for WB, IHC and so on.

Specifications

Product Name

Cytochrome P450 2E1 Antibody - Primary antibody, specific to CYP2E1, Rabbit IgG

Synonyms

4-nitrophenol 2-hydroxylase | CP2E1_HUMAN | CPE 1 | CPE1 | CYP2E | CYP2E1 | CYPIIE1 | Cytochrome P450 2E1 | cytochrome P450 family 2 subfamily E polypeptide 1 | Cytochrome P450 isozyme 3A | Cytochrome P450 LM3A | Cytochrome P450 subfamily IIE (ethanol ind

Specifications & Purity

Carrier Free, See COA

Biochemical and Physiological Mechanisms

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Host species

Rabbit

Specificity

CYP2E1

Immunogen

A synthetic peptide derived from human CYP2E1

Positive Control

WB: Mouse liver, kidney lysates.  IHC: Human liver, colorectal cancer tissues

Conjugation

Unconjugated

Grade

Carrier Free

Isotype

Rabbit IgG

SDS-PAGE

150 kDa

Purification Method

Antigen affinity purified

Concentration

See COA

Storage and Shipping

Shape

Liquid

Storage

Store at -20°C,Avoid repeated freezing and thawing

Shipped In

Ice chest + Ice pads

Stability And Storage

Store at 2-8℃ short term (1-2 weeks). Store at -20℃ long term (12 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Application

• Application: Dilution info
• IHC:

  1/50-1/200;

• WB:

  1/1000-1/5000 ;

Associated Targets(Human)

CYP2E1 Tchem Cytochrome P450 2E1 (0 Activities)

Discover Target: CYP2E1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

References

1. Yunqi Li, Yuan He, Ting Shao, Haixiang Pei, Weikai Guo, Dazhao Mi, Isabelle Krimm, Yuanjin Zhang, Peili Wang, Xin Wang, Mingyao Liu, Zhengfang Yi, Yihua Chen.  (2019)  Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:31026162] [10.1021/acs.jmedchem.9b00059]

2. Jun-Jie Yang, Wei-Wei Yu, Long-Long Hu, Wen-Juan Liu, Xian-Hua Lin, Wei Wang, Qiansen Zhang, Pei-Li Wang, Shuo-Wen Tang, Xin Wang, Mingyao Liu, Weiqiang Lu, Han-Kun Zhang.  (2019)  Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:31855426] [10.1021/acs.jmedchem.9b01269]