Desvenlafaxine - Moligand™, 10mM in DMSO , Norepinephrine transporter inhibitor, CAS No.93413-62-8, Norepinephrine transporter inhibitor

CAS: 93413-62-8 Cat. No.: D409248 Molecular Weight: 263.375 EC Number: 700-516-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

WY 45233 Succinate | Phenol, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Desvenlafaxine Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with K i of 40.2 nM and 558.4 nM, respectively.
In vitro

Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor and is the active metabolite of the antidepressant venlafaxine. Similar to venlafaxine, desvenlafaxine inhibits the neuronal uptake of serotonin and norepinephrine. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter. Desvenlafaxine inhibits [³H]5-HT or [³H]NE uptake for the hSERT or hNET with IC50 of 47.3 and 531.3 nM, respectively. Desvenlafaxine has the potential to inhibit CYP2D6, which could result in increased concentrations of drugs metabolized through this pathway. Induction of CYP3A4 is also possible with desvenlafaxine, which could impact the metabolism of drugs metabolized via this enzyme.

In vivo

Desvenlafaxine rapidly penetrates the male rat brain and hypothalamus. Desvenlafaxine significantly increases extracellular NE levels compared with baseline in the male rat hypothalamus but had no effect on DA levels using microdialysis. Desvenlafaxine exhibits a linear and dose-proportional pharmacokinetic single-dose profile in a dose range from 100 to 600 mg/day. The absolute bioavailability of the oral formulation is 80.5%.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

WY 45233 Succinate | Phenol, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with K_i of 40.2 nM and 558.4 nM, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Norepinephrine transporter inhibitor

Names and Identifiers

• Isomeric SMILES: CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
• Molecular Weight: 263.375
• Reaxy-Rn: 4234613
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4234613&ln=

Associated Targets(Human)

SLC6A2 Tclin Sodium-dependent noradrenaline transporter (2 Activities)

Discover Target: SLC6A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A3 Tclin Sodium-dependent dopamine transporter (1 Activities)

Discover Target: SLC6A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter (4 Activities)

Discover Target: SLC6A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 222 °C

References

1. Moying Yang, Yan Yao, Haotian Shen, Fei Teng, Yunuo Liu, Yuyang Ma, Bin Di, Mengxiang Su.  (2025)  Detection of antidepressants in wastewater from four provinces of China by UPLC-MS/MS to assess the regional prevalence of depression.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.114446]