DL-Tyrosine - ≥98% , CAS No.556-03-6

CAS: 556-03-6 Cat. No.: T108322 Molecular Weight: 181.19 Beilstein Registry Number: 515881 EC Number: 209-113-1

GRADE & PURITY ≥98%

Synonyms

(DL)-Tyrosine | 2-amino-3-(4-hydroxyphenyl)propanoic acid | 2-amino-3-(4-hydroxyphenyl)-propanoic acid | AI3-18479 | (2s)-tyrosine | Pharmakon1600-01300046 | SY014304 | DL-Tyrozine | DTXSID50859040 | (.+-.)-Tyrosine | DL-Tyrosine, puriss., >=99.0% (NT) |

Storage

Protected from light,Room temperature

Shipped In

Normal

Specifications

Synonyms

(DL)-Tyrosine | 2-amino-3-(4-hydroxyphenyl)propanoic acid | 2-amino-3-(4-hydroxyphenyl)-propanoic acid | AI3-18479 | (2s)-tyrosine | Pharmakon1600-01300046 | SY014304 | DL-Tyrozine | DTXSID50859040 | (.+-.)-Tyrosine | DL-Tyrosine, puriss., >=99.0% (NT) |

Specifications & Purity

≥98%

Storage

Protected from light, Room temperature

Shipped In

Normal

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488179604
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488179604
• Canonical Smiles: C1=CC(=CC=C1CC(C(=O)O)N)O
• IUPAC Name: 2-amino-3-(4-hydroxyphenyl)propanoic acid
• InChIKey: OUYCCCASQSFEME-UHFFFAOYSA-N
• INCHI: 1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)
• Isomeric SMILES: C1=CC(=CC=C1CC(C(=O)O)N)O
• WGK Germany: 3
• Molecular Weight: 181.19
• Beilstein: 515881
• Reaxy-Rn: 515881
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=515881&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Tyrosine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Tyrosine and derivatives
• Alternative Parents: Phenylalanine and derivatives Phenylpropanoic acids Amphetamines and derivatives Alpha amino acids Aralkylamines 1-hydroxy-2-unsubstituted benzenoids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Tyrosine or derivatives - Phenylalanine or derivatives - 3-phenylpropanoic-acid - Amphetamine or derivatives - Alpha-amino acid - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Phenol - Monocyclic benzene moiety - Benzenoid - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxygen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Primary aliphatic amine - Organic nitrogen compound - Carbonyl group - Organic oxide - Organopnictogen compound - Amine - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as tyrosine and derivatives. These are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: alpha-amino acid - aromatic amino acid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Bacillus subtilis (32866 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gria2 Glutamate receptor ionotropic, AMPA (2103 Activities)

Discover Target: Gria2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Light sensitive.
• Melt Point(°C): ≥300°C
• Molecular Weight: 181.190 g/mol
• XLogP3: -2.300
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 181.074 Da
• Monoisotopic Mass: 181.074 Da
• Topological Polar Surface Area: 83.600 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 176.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Zhiqiang Wei, Shaofang Guo, Liuyang Cheng, Ting Li, Yanli Zhang, Hui Yang.  (2023)  Simultaneous Determination of Acetaminophen and Tyrosine Using Screen-printed Electrochemical Sensor Based on MWCNTs-doped Poly(glycine)/Poly(acrylic acid) Conducting Polymers.  International Journal of Electrochemical Science,      [PMID:36864527] [10.20964/2019.07.26]

2. Jian Zhang, Lingling Liang, Yanqing Miao, Yang Yang, Xin Bao, Chunye Liu.  (2022)  Open-tubular capillary electrochromatography with hydroxypropyl-β-cyclodextrin imprinted polymers: hybrid polyhedral oligomeric silsesquioxane as a coating for enantioseparation.  RSC Advances,  12  (16): (9637-9644).  [PMID:35424918] [10.1039/D2RA00079B]

3. Yi-lin Chai, Zi-bo Gao, Zhuang Li, Lei-liang He, Fei Yu, Song-cheng Yu, Jia Wang, Yong-mei Tian, Li-e Liu, Yi-lin Wang, Yong-jun Wu.  (2020)  A novel fluorescent nanoprobe that based on poly(thymine) single strand DNA-templated copper nanocluster for the detection of hydrogen peroxide.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:32505107] [10.1016/j.saa.2020.118546]

4. Qing Xiong, Jing Jin, Liqiong Lv, Zhisi Bu, Shengqiang Tong.  (2018)  Chiral ligand exchange countercurrent chromatography: Enantioseparation of amino acids.  JOURNAL OF SEPARATION SCIENCE,  41  (6): (1479-1488).  [PMID:29323783] [10.1002/jssc.201701117]

5. Lu Zhang, Jun-qing Yang, Ying Luo, Jing-chuan Shang, Xin-hui Jiang.  (2015)  Simultaneous determination of eleven compounds related to metabolism of bioamines in rat cortex and hippocampus by HPLC-ECD with boron-doped diamond working electrode.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:26512998] [10.1016/j.jpba.2015.10.020]

6. Hongkai Xie, Wenhua Ji, Dahui Liu, Wei Liu, Daijie Wang, Ruimin Lv, Xiao Wang.  (2015)  Surface molecularly imprinted polymers with dummy templates for the separation of dencichine from Panax notoginseng.  RSC Advances,  5  (60): (48885-48892).  [PMID:] [10.1039/C5RA06749A]

7. Xuan Zhang, Fang Wang, Zilin Chen.  (2024)  Electrochemical chiral sensor for recognition of amino acid enantiomers with cyclodextrin-based microporous organic networks.  ANALYTICA CHIMICA ACTA,      [PMID:38969416] [10.1016/j.aca.2024.342879]

8. Qinhua Liu, Xuan Kuang.  (2025)  Electrochemiluminescent Chiral Sensor Based on Covalent Organic Frameworks for Discrimination of Phenylalanine Enantiomers.  CHIRALITY,  37  (7): (e70040).  [PMID:40619728] [10.1002/chir.70040]

9. Jianjun Wang, Xueqing Liu, Dongning Li, Jiao Liu, Zhichun Shi, Yu Zang, Toshiki Aoki.  (2025)  Innovative amino acid-porphyrin decorated hyper-crosslinked polymers for efficient electrosorption of uranium (VI) in aqueous solution.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.135442]

10. Zenghui Xie, Jiana Lin, Yuling Hu, Gongke Li.  (2025)  Pore Segmentation Strategy of Calixarene-Based Covalent Organic Frameworks for Chiral Selective Transmembrane Transport of Amino Acids.  ANALYTICAL CHEMISTRY,      [PMID:41251229] [10.1021/acs.analchem.5c05490]