Inflammasomes are important cytoplasmic signaling complexes of the innate immune system that sense infection, cellular injury, and metabolic abnormalities. They activate inflammatory Caspases, promote the maturation of IL-1β and IL-18, and drive Gasdermin-mediated pyroptosis. Inflammasomes such ...
Intracellular DNA sensing is not always triggered directly by exogenous pathogens. In many noninfectious stress settings, its upstream origin is first a disruption of mitochondrial metabolic homeostasis. Taking CRAT deficiency as the point of entry, acetyl-group buffering failure, mtDNA stress, ...
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