Not every new scaffold can become a practical building block in medicinal chemistry. For a new structure to be truly noteworthy, it should answer at least three questions at the same time: Can it introduce a clear three-dimensional structural change? Can it be prepared reliably on a sufficient ...
The Biginelli Reaction is an acid-catalyzed three-component reaction between an aromatic aldehyde, a β-keto ester, and a urea (e.g., urea, thiourea) to produce a tetrahydropyrimidinone with potential pharmaceutical applications.
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