Articles by Topic "Cross-coupling reactions"

1. Experimental Decision-Making for Cross-Coupling Reactions: Target Bond Type, Substrate Combination, and Catalytic System Selection
   posted this at May 8, 2026

   2
   Cross-coupling refers to the connection of two molecular fragments under the action of a metal catalyst to form a new chemical bond. In organic synthesis, these reactions are most commonly used to construct carbon–carbon bonds, and they have also been widely extended to carbon–nitrogen and ...
2. How to Make the Suzuki–Miyaura Reaction Robust: Pinpoint the Bottleneck and Lock in a Reproducible Operating Window (with Selection Navigation and Product Tables 1–5)
   posted this at Feb 26, 2026

   2
   In pharmaceuticals, agrochemical intermediates, and organic functional materials, building C–C bonds is rarely a one-off “do it once and done” task. The same transformation tends to reappear across different substrates, different functional-group combinations, different scales, and ...
3. Study on Alkenyl Fluorinated Building Blocks
   posted this at Jun 9, 2025

   2
   Due to the small radius of fluorine atom and its strongest electronegativity (4.0), the introduction of fluorine atom will change the polarity direction of C-F bond and the electron cloud distribution of the whole molecule, which will affect the dipole moment, acidity and basicity of the ...