The BAFF pathway and the PD-1 pathway represent two typical directions in immune regulation by therapeutic monoclonal antibodies. The BAFF pathway mainly regulates B-cell survival, maturation, and autoantibody production, making it suitable for studies related to autoimmunity and abnormal ...
Programmed cell death protein 1, also known as PD-1 and CD279, is a cell surface receptor that plays an important role in downregulating the immune system and promoting self-tolerance by inhibiting T cell inflammatory activity. In humans, it is encoded by the PDCD1 gene. PD-1 is a member of the ...
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