Solid-Phase Peptide Synthesis

Step-by-step protocol for using Fmoc-Cys(Me)-OH in Fmoc solid-phase peptide synthesis, including storage, dissolution, coupling, and deprotection conditions.

Step-by-step protocol for handling and coupling Fmoc-D-Asp-Oall in solid-phase peptide synthesis, including deprotection and allyl ester removal.

Peptides have become an important class of molecules in modern medicinal chemistry and chemical biology. Compared with traditional small molecules, peptides often offer higher target selectivity and stronger molecular recognition capability, while still retaining good structural tunability. As a ...

Solid-Phase Peptide Synthesis (SPPS) is a method in which a growing peptide chain is covalently “tethered” to insoluble resin beads, and the synthesis proceeds through repeated cycles of “deprotection → coupling one amino acid → washing.” Because the peptide remains attached to the ...