The Methodological Value of TCFH: Advantages in Challenging Amidation and the Switching Logic of Carboxylic Acid Activation Pathways

TCFH [N,N,N′,N,N′-tetramethylchloroformamidinium hexafluorophosphate] is often simply classified as a “powerful coupling reagent,” but a more accurate description is that it is a carboxylic acid activation reagent capable of directing carboxylic acids into different highly reactive ...