Fmoc-Lys(Me)₃-OH Chloride - ≥97% , CAS No.201004-29-7

CAS: 201004-29-7 Cat. No.: F168351 Molecular Weight: 446.97

GRADE & PURITY ≥97%

Synonyms

(S)-5-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-carboxy-N,N,N-trimethylpentan-1-aminium chloride | Fmoc-Lys(Me3)-OH.nCl | F10733 | (S)-5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-carboxy-N,N,N-trimethylpentan-1-aminium n-chloride | Fmoc-Lys(Me)3-O

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Fmoc protected N-trimethyl lysine

Application

Fmoc-Lys(Me)3-OH chloride is one of the common N-terminal protected reagents used in the peptide synthesis. Some of the reported examples are:

Synthesis of peptide linkers for monoclonal antibody-auristatin F conjugates.

Preparation of multifunctional reagents with enhanced ionization properties for the analysis of protein modification in human cells and dynamic profiling of protein lipidation.

Sequential peptide ligation to synthesize histone H3 containing a trimethyl lysine residue, with modified tail region.

Specifications

Synonyms

(S)-5-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-carboxy-N, N, N-trimethylpentan-1-aminium chloride | Fmoc-Lys(Me3)-OH.nCl | F10733 | (S)-5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-carboxy-N, N, N-trimethylpentan-1-aminium n-chloride | Fmoc-Lys(Me)3-O

Specifications & Purity

≥97%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 488201478
• Canonical Smiles: C[N+](C)(C)CCCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13.[Cl-]
• IUPAC Name: [(5S)-5-carboxy-5-(9H-fluoren-9-ylmethoxycarbonylamino)pentyl]-trimethylazanium;chloride
• InChIKey: XUJRNPVABVHOAJ-FTBISJDPSA-N
• INCHI: 1S/C24H30N2O4.ClH/c1-26(2,3)15-9-8-14-22(23(27)28)25-24(29)30-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21;/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H-,25,27,28,29);1H/t22-;/m0./s1
• Isomeric SMILES: C[N+](C)(C)CCCC[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13.[Cl-]
• WGK Germany: 3
• Molecular Weight: 446.97
• Reaxy-Rn: 44419961
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=44419961&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Fluorenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Fluorenes
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Fluorenes
• Alternative Parents: Alpha amino acids and derivatives Medium-chain fatty acids Tetraalkylammonium salts Carbamate esters Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Organic chloride salts Hydrocarbon derivatives Carbonyl compounds Amines Organic cations
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Fluorene - Alpha-amino acid or derivatives - Medium-chain fatty acid - Fatty acid - Fatty acyl - Quaternary ammonium salt - Carbamic acid ester - Tetraalkylammonium salt - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic salt - Organic oxide - Amine - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Carbonyl group - Hydrocarbon derivative - Organic chloride salt - Organic cation - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as fluorenes. These are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Sensitivity: Moisture sensitive
• Molecular Weight: 447.000 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 446.197 Da
• Monoisotopic Mass: 446.197 Da
• Topological Polar Surface Area: 75.600 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 566.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3