GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 7 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Information
Furosemide (NSC 269420) Furosemide (NSC 269420) is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used in the treatment of congestive heart failure and edema. In vitro
Furosemide reversibly alters the responses to tones and clicks of the chinchilla basilar membrane in hair cells, causing response-magnitude reductions that are largest (up to 61 dB, averaging 25-30 dB) at low stimulus intensities at the characteristic frequency (CF) and small or nonexistent at high intensities and at frequencies far removed from CF. Furosemide also induces response-phase lags that are largest at low stimulus intensities (averaging 77 degrees) and are confined to frequencies close to CF. Furosemide concentration- and time-dependently increases the formation of nitric oxide andprostacyclin. Furosemide leads to an enhanced release of kinins into the supernatant of the cells. Furosemide reversibly suppresses low Ca2+-induced epileptiform activity in hippocampus proper and blocks or significantly reduces different types of epileptiform discharges in the low Mg2+ model and the 4-aminopyridine model. Furosemide significantly inhibits cell growth in MKN45 cells, but not in MKN28 cells. Furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity.
In vivo
Furosemide (0.25 to 2 mg/kg), administered 4 hours before exercise, reduces right atrial pressure (RAP) and pulmonary arterial pressure (PAP) during exercise in dose-dependent manner in horse. Cell Data
1.Guang-Rong Wu, Jia-Kun Xu, Li-Juan Sun, Ying-Fu Li, Shu-Qin Gao, Ying-Wu Lin. (2023) Application of engineered heme enzymes based on myoglobin with high peroxidase activity for efficient degradation of various emerging pollutants. Journal of Environmental Chemical Engineering, [PMID:][10.1016/j.jece.2023.111471]
5.Zhu Zaisheng, Xu Lingling, Liu Yujie, Wang Xiufang, Tian Yong. (2022) The synthesis of novel nanoparticles: transition from hollow to groove via self-template sacrifice strategy. JOURNAL OF POROUS MATERIALS, 29 (4):(1049-1059). [PMID:][10.1007/s10934-022-01229-x]
6.Jingxuan Qiu, Jing Lin, Chaoqun Zhang, Liping Zhao, Peng Wang, Jia Zhang, Rui Zhang, Yunchun Guo, Huiliang Wang. (2024) Solid-Liquid Equilibrium Behavior and Data Correlation of Furosemide in 12 Pure Solvents from 283.15 to 323.15 K. JOURNAL OF CHEMICAL AND ENGINEERING DATA, [PMID:][10.1021/acs.jced.4c00089]
7.Rui Hu, Hao-Tong Zheng, Boxi Tang, Jialing Tu, Yu-Hong Cui, Xuedong Zhai, Gang Wen, Zheng-Qian Liu. (2026) Revisit the improvement of coagulation pretreatment on ozonation performance: The critical roles of HO• and O3 for effluent organic matter transformation and micropollutant degradation. Journal of Cleaner Production, [PMID:][10.1016/j.jclepro.2026.147988]
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