IQDMA - ≥98% , CAS No.401463-02-3

CAS: 401463-02-3 Cat. No.: I275346 Molecular Weight: 304.39

GRADE & PURITY ≥98%

Synonyms

N2-11H-Indolo[3,2-c]quinolin-6-yl-N1,N1-dimethyl-1,2-ethanediamine

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Store at +4°C. The product can be stored for up to 12 months.

Specifications

Synonyms

N2-11H-Indolo[3, 2-c]quinolin-6-yl-N1, N1-dimethyl-1, 2-ethanediamine

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Cell-permeable STAT5 inhibitor (IC 50 = 8 μM). Indoloquinoline derivative. Antineoplastic agent with broad spectrum antitumor activity seen in vitro . Induces cell-cycle arrest at the G 2 /M phase.

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CN(C)CCNC1=NC2=CC=CC=C2C3=C1C4=CC=CC=C4N3
• IUPAC Name: N-(11H-indolo[3,2-c]quinolin-6-yl)-N',N'-dimethylethane-1,2-diamine
• InChIKey: UROLFQZUYMCOHV-UHFFFAOYSA-N
• INCHI: 1S/C19H20N4/c1-23(2)12-11-20-19-17-13-7-3-5-9-15(13)21-18(17)14-8-4-6-10-16(14)22-19/h3-10,21H,11-12H2,1-2H3,(H,20,22)
• Isomeric SMILES: CN(C)CCNC1=NC2=CC=CC=C2C3=C1C4=CC=CC=C4N3
• Molecular Weight: 304.39
• Reaxy-Rn: 20206145
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20206145&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Quinolines and derivatives
      • Subclass Indoloquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Quinolines and derivatives
• Subclass: Indoloquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: Indoloquinolines
• Alternative Parents: Pyrrolo[3,2-c]quinolines Gamma carbolines Aminoquinolines and derivatives Pyrrolopyridines Indoles Aminopyridines and derivatives Imidolactams Benzenoids Pyrroles Heteroaromatic compounds Trialkylamines Azacyclic compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indoloquinoline - Pyrrolo[3,2-c]quinoline - Gamma-carboline - Pyrroloquinoline - Aminoquinoline - Indole - Indole or derivatives - Pyrrolopyridine - Aminopyridine - Pyridine - Benzenoid - Imidolactam - Pyrrole - Heteroaromatic compound - Tertiary amine - Tertiary aliphatic amine - Azacycle - Organic nitrogen compound - Organonitrogen compound - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as indoloquinolines. These are polycyclic aromatic compounds containing an indole fused to a quinoline.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

Detroit 551 (346 Activities)

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PC-3 (62116 Activities)

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A549 (127892 Activities)

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HeLa (62764 Activities)

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Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

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L6 (7924 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in DMSO to 100 mM and in ethanol to 100 mM