Cyclin-dependent kinase-like 5 (CDKL5)

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  1. P276-00
    CAS: 920113-03-7 Formula: C21H20ClNO5.HCl Molecular Weight: 438.3
    In Stock Item #: P129988
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    IUPAC Name
    2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one;hydrochloride
    SMILES
    CN1CCC(C1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
    InChIKey
    OOVTUOCTLAERQD-OJMBIDBESA-N
    InChI
    1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12-show more
    Synonyms
    A903150 | D72431 | EX-A2121 | P276 | AS-78319 | DRP53ZDY6H | P-27600;2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(h...
  2. AT7519, Cyclin-dependent kinase inhibitor
    CAS: 844442-38-2 Formula: C16H17Cl2N5O2 Molecular Weight: 382.24
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: A127001
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    IUPAC Name
    4-[(2,6-dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide
    SMILES
    C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl
    InChIKey
    OVPNQJVDAFNBDN-UHFFFAOYSA-N
    InChI
    1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24)
    Synonyms
    NSC773394 | NSC-773394 | SY009677 | BDBM24654 | CCG-264904 | NSC799338 | NSC-799338 | OVPNQJVDAFNBDN-UHFFFAOYSA-N | 4...
  3. Defactinib
    CAS: 1073154-85-4 EC Number: 969-109-7 Formula: C20H21F3N8O3S Molecular Weight: 510.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: D275494
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    IUPAC Name
    N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide
    SMILES
    CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F
    InChIKey
    FWLMVFUGMHIOAA-UHFFFAOYSA-N
    InChI
    1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)show more
    Synonyms
    VS 6063 | PF-04554878 | NSC800089 | NSC-800089 | 53O87HA2QU | Benzamide, N-methyl-4-((4-(((3-(methyl(methylsulfonyl)a...
  4. SNS-032 (BMS-387032), Cyclin-dependent kinase 9 inhibitor
    CAS: 345627-80-7 EC Number: 892-362-9 PubChem CID: 3025986 Formula: C17H24N4O2S2 Molecular Weight: 380.53
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: S126734
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    IUPAC Name
    N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
    SMILES
    CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
    InChIKey
    OUSFTKFNBAZUKL-UHFFFAOYSA-N
    InChI
    1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
    Synonyms
    HY-10008 | J-523350 | SNS-032 (BMS-387032) | 345627-80-7 (free base) | CHEBI:91399 | n-[5-[[[5-(1,1-dimethylethyl)-2-...
  5. AT7519, Cyclin-dependent kinase inhibitor
    CAS: 844442-38-2 Formula: C16H17Cl2N5O2 Molecular Weight: 382.24
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: A408650
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    Synonyms
    4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide
  6. Capmatinib (INCB28060), Hepatocyte growth factor receptor inhibitor
    CAS: 1029712-80-8 EC Number: 813-241-9 Formula: C23H17FN6O Molecular Weight: 412.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 2mM in DMSO
    In Stock Item #: C408636
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    Technical Identifiers
    Synonyms
    INC280, NVP-INC280 | 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide
  7. Capmatinib (INCB28060), Hepatocyte growth factor receptor inhibitor
    CAS: 1029712-80-8 EC Number: 813-241-9 Formula: C23H17FN6O Molecular Weight: 412.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: I127200
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    Technical Identifiers
    IUPAC Name
    2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
    SMILES
    CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F
    InChIKey
    LIOLIMKSCNQPLV-UHFFFAOYSA-N
    InChI
    1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
    Synonyms
    INCB-28060 | INC-280 | AMY18553 | CCG-268791 | HY-13404 | O-(4-(dimethylsulfamoyl)phenyl) O,O-dimethyl thiophosphate ...
  8. Defactinib
    CAS: 1073154-85-4 EC Number: 969-109-7 Formula: C20H21F3N8O3S Molecular Weight: 510.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 2mM in DMSO
    Out of Stock Item #: D420521
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    IUPAC Name
    N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide
    SMILES
    CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F
    InChIKey
    FWLMVFUGMHIOAA-UHFFFAOYSA-N
    InChI
    1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)show more
    Synonyms
    NSC800089 | NSC-800089 | 53O87HA2QU | Benzamide, N-methyl-4-((4-(((3-(methyl(methylsulfonyl)amino)-2-pyrazinyl)methyl...
  9. Riviciclib hydrochloride (P276-00)
    CAS: 920113-03-7 Formula: C21H20ClNO5.HCl Molecular Weight: 438.3
    10mM in DMSO
    In Stock Item #: R408953
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    Technical Identifiers
    Synonyms
    4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-, hydro...
  10. SNS-032 (BMS-387032), Cyclin-dependent kinase 9 inhibitor
    CAS: 345627-80-7 EC Number: 892-362-9 PubChem CID: 3025986 Formula: C17H24N4O2S2 Molecular Weight: 380.53
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: S407752
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    Technical Identifiers
    Synonyms
    N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)piperidine-4-carboxamide
  11. Capmatinib
    CAS: 1029712-80-8 EC Number: 813-241-9 Formula: C23H17FN6O Molecular Weight: 412.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    Out of Stock Item #: C1496290
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  12. Defactinib
    CAS: 1073154-85-4 EC Number: 969-109-7 Formula: C20H21F3N8O3S Molecular Weight: 510.49
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    Out of Stock Item #: D1495477
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