Mestranol - Moligand™, 10mM in DMSO , Estrogen receptor alpha agonist, CAS No.72-33-3, Estrogen receptor alpha agonist

CAS: 72-33-3 Cat. No.: M409226 Formula: C₂₁H₂₆O₂ Molecular Weight: 310.43 Beilstein Registry Number: 2625905 EC Number: 200-777-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(17α)​-3-​methoxy-19-​norpregna-​1,​3,​5(10)​-​trien-​20-​yn-​17-​ol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potentestrogen receptoragonist and used as oral contraceptives.
In vitro

Mestranol is extensively metabolized to hydroxylated products whose bio- logical activity is less well characterized.

In vivo

Mestranol (0.2 mg/kg) results in an increased percentage of liver occupied by AHF expressing glutathione S-transferase (PGST) in rats. Mestranol administration increases the focal hepatocyte labeling index compared with the control with a trend at the lower dose and a significant difference at the higher dose. Mestranol (0.02 mg/kg and 0.2 mg/kg diet) results in a decrease in the non-focal labeling index compared with that observed for the corresponding concentration of Mestranol alone. Mestranol significantly increases the non-focal hepatic labeling index in uninitiated rats compared with that observed in rats administered the basal diet only. Mestranol (50 mg/100 g b.wt.) has a significant reduction in the apparent number of alpha-2-adrenoceptors in the frontal cortex and nucleus tractus solitarius (NTS) of rat, while apparent numbers of both alpha-1 and alpha-2-adrenoceptors are depressed in the locus coeruleus.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

(17α)​-3-​methoxy-19-​norpregna-​1,​3,​5(10)​-​trien-​20-​yn-​17-​ol

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Estrogen receptor alpha agonist

Product Properties

• ALogP: 4

Names and Identifiers

• Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)OC
• WGK Germany: 3
• RTECS: RC8960000
• Molecular Weight: 310.43
• Beilstein: 2625905
• Reaxy-Rn: 8930321
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8930321&ln=

Associated Targets(Human)

ESR1 Tclin Estrogen receptor (2 Activities)

Discover Target: ESR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC6A4 Tclin Sodium-dependent serotonin transporter (2 Activities)

Discover Target: SLC6A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 31 mg/mL (199.75 mM); Water: Insoluble; Ethanol: Insoluble
• Specific Rotation[α]: [α]D：4° (C=2,Dioxane)
• Melt Point(°C): 151 °C