10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 8 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Mitoxantrone 2HCl (NSC-301739) is a dihydrochloride salt of Mitoxantrone. Mitoxantrone is an inhibitor oftype II topoisomeraseandprotein kinase C (PKC)with IC50 of 8.5 μM for PKC. Mitoxantrone inhibits cell proliferative growth of MCF-7/wt cells with IC50
In vitro
Mitoxantrone induces DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), a marker of the activation of caspases, in all the patients studied, demonstrating that the cytotoxic effect of mitoxantrone is due to induction of apoptosis. Mitoxantrone activates NFkappaB and stimulates IkappaBalpha degradation in the promyelocytic leukemia cell line HL60 but not in the variant cells, HL60/MX2 cells, which lack the beta isoform of topoisomerase II and express a truncated alpha isoform that results in an altered subcellular distribution. Mitoxantrone inhibits proliferation of activated PBMCs, B lymphocytes, or antigen-specific T-cell lines (TCLs) stimulated on antigen-presenting cells (APCs) in a dose-dependent manner. Mitoxantrone induces apoptosis of PBMCs, monocytes and DCs at low concentrations, whereas higher doses causes cell lysis.
In vivo
Mitoxantrone transiently decreases the growth rate of HID xenografts in mice but does not affect that of PAC120 xenografts. Mitoxantrone results in the severity of the cardiac lesions and the nephropathy and the intestinal toxicity in spontaneously hypertensive rats. Mitoxantrone and iron(III) form a strong 2:1 complex, in which mitoxantrone may be acting as a tridentate ligand.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥95%
| Isomeric SMILES | C1=CC(=C2C(=C1NCCNCCO)C(=O)C3=C(C=CC(=C3C2=O)O)O)NCCNCCO.Cl.Cl |
|---|---|
| Alternate CAS | 65271-80-9 |
| PubChem CID | 51082 |
| Molecular Weight | 517.4 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 4.89 mg/mL (37.85 mM); |
|---|---|
| Melt Point(°C) | 267 °C(dec.) |
| 1. Chengming Tian, Mengchi Sun, Zhichao Chen, Jiawei Shi, Chen Xu, Meng Niu, Jin Sun, Hongzan Sun. (2025) Coordination-Guided Therapeutic-Coating Oncolytic Bacteria Enabling Pyroptosis Amplification and Synergistic Breast Tumor Suppression. ADVANCED FUNCTIONAL MATERIALS, [PMID:] [10.1002/adfm.202507322] |
| 2. Zhen Li, Xingtong Liu, Linna Li, Yandi Hui, Lili Liu, Fujun Yao, Xiaofeng Kang, Yanli Guo. (2025) Nanopore-Based Strategy for Single-Nucleotide Mutation Detection in Sickle Cell Disease Using Anthracycline Probes. ANALYTICAL CHEMISTRY, [PMID:40693513] [10.1021/acs.analchem.5c02351] |
| 3. Wanqian Cai, Chongbiao Zhang, Yourong Wu, Wei Wang, Mei Lin, Tengfei Lin, Cong Lin, Min Gao, Chunlin Zhao, Xiao Wu. (2023) H2O2 activated moxa ash via ball milling for ultrafast removal of mitoxantrone. RSC Advances, 13 (17): (11720-11727). [PMID:37063737] [10.1039/D3RA00988B] |
| 4. Deng Hao-Hua, Yang Hui-Jing, Huang Kai-Yuan, Zheng Yi-Jing, Xu Ying-Ying, Peng Hua-Ping, Liu Yin-Huan, Chen Wei, Hong Guo-Lin. (2022) Antenna effect of pyridoxal phosphate on the fluorescence of mitoxantrone-silicon nanoparticles and its application in alkaline phosphatase assay. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (17): (4877-4884). [PMID:35576012] [10.1007/s00216-022-04110-7] |
| 5. Mei Lin, Jianwang Wu, Zuliang Chen. (2024) A novel self-assembled ZIF-67 hollow prisms for high-efficient simultaneous removal of ciprofloxacin and lead. APPLIED SURFACE SCIENCE, [PMID:] [10.1016/j.apsusc.2024.159350] |
| 6. Haiying Liu, Yuqi Liu, Xiaoxi Lin, Jianhui Fan, Zhao Huang, Ao Li. (2024) Mitoxantrone attenuates lipopolysaccharide-induced acute lung injury via inhibition of NEDD8 activating enzyme. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:39541844] [10.1016/j.intimp.2024.113605] |
| 7. Zhuting Yang, Xuezhang Shi, Liyan Qiu. (2024) Tunable supramolecular self-assemblies based on cyclodextrin polymer as a loading platform for water-soluble drugs. CARBOHYDRATE POLYMERS, [PMID:39486972] [10.1016/j.carbpol.2024.122743] |
| 8. Yadong Tang, Boxin Huang, Yuqin Dong, Wenlong Wang, Xi Zheng, Wei Zhou, Kun Zhang, Zhiyun Du. (2017) Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, [PMID:28583017] [10.1080/09205063.2017.1338502] |
