N-Ethylmaleimide(NEM) - Moligand™, ≥98% , CAS No.128-53-0

Name: N-Ethylmaleimide(NEM) - Moligand™, ≥98% , CAS No.128-53-0
SKU: E100552
Availability: InStock

CAS: 128-53-0 Cat. No.: E100552 Formula: C₆H₇NO₂ Molecular Weight: 125.13 Beilstein Registry Number: 112448 EC Number: 204-892-4

73 Citations COA

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N-Ethylmaleimide(NEM) - Moligand™, ≥98% CAS No(128-53-0) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY Moligand™ ? ≥98%

Synonyms

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Citations of This Product Solution Calculators Reviews

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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 73 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Reagent for the covalent modification of cysteine residues in proteins. Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels. Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

Specifications

Synonyms

Specifications & Purity

Moligand™, ≥98%

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥98%

Names and Identifiers

Pubchem Sid

488179828

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488179828

Canonical Smiles

CCN1C(=O)C=CC1=O

IUPAC Name

1-ethylpyrrole-2,5-dione

InChIKey

HDFGOPSGAURCEO-UHFFFAOYSA-N

INCHI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3

Isomeric SMILES

CCN1C(=O)C=CC1=O

WGK Germany

RTECS

UX9625000

Alternate CAS

25668-22-8,128-53-0,25668-22-8

NSC Number

7638

UN Number

2928

MeSH Entry Terms

Ethylmaleimide;N Ethylmaleimide;N-Ethylmaleimide

Molecular Weight

125.13

Beilstein

112448

Reaxy-Rn

112448

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=112448&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyrrolidines
    - Subclass Pyrrolidones

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyrrolidines
Subclass	Pyrrolidones
Intermediate Tree Nodes	Not available
Direct Parent	Maleimides
Alternative Parents	N-substituted carboxylic acid imides Pyrrolines Dicarboximides Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic heteromonocyclic compounds
Substituents	Maleimide - Carboxylic acid imide, n-substituted - Carboxylic acid imide - Dicarboximide - Pyrroline - Azacycle - Carboxylic acid derivative - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Aliphatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as maleimides. These are compounds containing a 2,5-pyrroledione moiety.
External Descriptors	a small molecule
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

TYMS Tclin Thymidylate synthase (1651 Activities)

Discover Target: TYMS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOB Tclin Monoamine oxidase B (8835 Activities)

Discover Target: MAOB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A3 Tclin Dopamine transporter (10535 Activities)

Discover Target: SLC6A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALB Tchem Serum albumin (2651 Activities)

Discover Target: ALB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Lot Number	Certificate Type	Date	Item
A2517245	Certificate of Analysis	Sep 22, 2026	E100552
I2614672	Certificate of Analysis	Sep 18, 2026	E100552
I2614671	Certificate of Analysis	Sep 18, 2026	E100552
I2614669	Certificate of Analysis	Sep 18, 2026	E100552
I2614653	Certificate of Analysis	Sep 18, 2026	E100552
C2303600	Certificate of Analysis	Sep 03, 2026	E100552
C2303599	Certificate of Analysis	Sep 03, 2026	E100552
C2303495	Certificate of Analysis	Sep 03, 2026	E100552
C2303496	Certificate of Analysis	Sep 03, 2026	E100552
C2303499	Certificate of Analysis	Sep 03, 2026	E100552
C2303500	Certificate of Analysis	Sep 03, 2026	E100552
E2614193	Certificate of Analysis	May 21, 2026	E100552
E2614194	Certificate of Analysis	May 21, 2026	E100552
E2614246	Certificate of Analysis	May 21, 2026	E100552
G2509539	Certificate of Analysis	Jul 11, 2025	E100552
G2509540	Certificate of Analysis	Jul 11, 2025	E100552
G2509541	Certificate of Analysis	Jul 11, 2025	E100552
G2509542	Certificate of Analysis	Jul 11, 2025	E100552
L2509029	Certificate of Analysis	Jul 11, 2025	E100552
C2609093	Certificate of Analysis	Jul 11, 2025	E100552
F2509065	Certificate of Analysis	Jun 21, 2025	E100552
E2507340	Certificate of Analysis	May 08, 2025	E100552
E2507345	Certificate of Analysis	May 08, 2025	E100552
E2507327	Certificate of Analysis	May 08, 2025	E100552
E2507339	Certificate of Analysis	May 08, 2025	E100552
A2417235	Certificate of Analysis	Jan 20, 2025	E100552
A2417246	Certificate of Analysis	Jan 20, 2025	E100552
A2517234	Certificate of Analysis	Jan 20, 2025	E100552
A2517235	Certificate of Analysis	Jan 20, 2025	E100552
A2517236	Certificate of Analysis	Jan 20, 2025	E100552
A2517246	Certificate of Analysis	Jan 20, 2025	E100552
G2402051	Certificate of Analysis	Jul 05, 2024	E100552
L2402219	Certificate of Analysis	Apr 25, 2024	E100552
D2412071	Certificate of Analysis	Apr 20, 2024	E100552
K2110379	Certificate of Analysis	Aug 02, 2023	E100552
K2110378	Certificate of Analysis	May 17, 2023	E100552
I2405073	Certificate of Analysis	Mar 09, 2023	E100552
A2426035	Certificate of Analysis	Mar 09, 2023	E100552
C2303490	Certificate of Analysis	Mar 09, 2023	E100552
C2303489	Certificate of Analysis	Mar 09, 2023	E100552
F2214549	Certificate of Analysis	Jun 20, 2022	E100552
F2214548	Certificate of Analysis	Jun 20, 2022	E100552
F2214550	Certificate of Analysis	Jun 20, 2022	E100552
F2202027	Certificate of Analysis	Jun 16, 2022	E100552
F2204274	Certificate of Analysis	Jun 16, 2022	E100552
F1828014	Certificate of Analysis	Feb 22, 2022	E100552
F2214547	Certificate of Analysis	Nov 17, 2021	E100552
K2110380	Certificate of Analysis	Nov 17, 2021	E100552

Solubility	Soluble in water
Sensitivity	Light Sensitive
Flash Point(°F)	163.4℉
Flash Point(°C)	73°C
Boil Point(°C)	210°C
Melt Point(°C)	43-46°C
Molecular Weight	125.130 g/mol
XLogP3	0.900
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	125.048 Da
Monoisotopic Mass	125.048 Da
Topological Polar Surface Area	37.400 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	165.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

N-Ethylmaleimide(NEM) - Moligand™, ≥98% , CAS No.128-53-0

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

📚 Citations by Application

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