Neutral red solution - 4% in water , CAS No.553-24-2

CAS: 553-24-2 Cat. No.: N131022 Molecular Weight: 288.78 EC Number: 209-035-8
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GRADE & PURITY 4% in water
Synonyms
EINECS 209-035-8 | Phenazine, 3-amino-7-(dimethylamino)-2-methyl-, hydrochloride | NEUTRAL RED | C.I. 50040 | NeutralRed | AI3-60242 | HY-D0166A | N0315 | N-2527 | C.I. Basic Red 5, monohydrochloride (VAN) | Michrome No. 226 | N0112 | C15H17N4Cl | Neutral
Storage
Room temperature
Shipped In
Normal
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Size
Status
Price
Qty
500ml
N131022-500ml
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Why this grade

4% in water for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 106 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
EINECS 209-035-8 | Phenazine, 3-amino-7-(dimethylamino)-2-methyl-, hydrochloride | NEUTRAL RED | C.I. 50040 | NeutralRed | AI3-60242 | HY-D0166A | N0315 | N-2527 | C.I. Basic Red 5, monohydrochloride (VAN) | Michrome No. 226 | N0112 | C15H17N4Cl | Neutral
Specifications & Purity
4% in water
Storage
Room temperature
Shipped In
Normal
Names and Identifiers
Canonical SmilesCC1=CC2=NC3=C(C=C(C=C3)N(C)C)N=C2C=C1N.Cl
IUPAC Name8-N,8-N,3-trimethylphenazine-2,8-diamine;hydrochloride
InChIKeyPGSADBUBUOPOJS-UHFFFAOYSA-N
INCHI1S/C15H16N4.ClH/c1-9-6-13-15(8-11(9)16)18-14-7-10(19(2)3)4-5-12(14)17-13;/h4-8H,16H2,1-3H3;1H
Isomeric SMILES CC1=CC2=NC3=C(C=C(C=C3)N(C)C)N=C2C=C1N.Cl
Molecular Weight 288.78
Reaxy-Rn 3918740
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3918740&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

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📊 Datasheet

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🔬 Specification Sheet

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassDiazanaphthalenes
SubclassBenzodiazines
Intermediate Tree Nodes Quinoxalines
Direct ParentPhenazines and derivatives
Alternative Parents Dialkylarylamines  Pyrazines  Benzenoids  Heteroaromatic compounds  Azacyclic compounds  Primary amines  Organopnictogen compounds  Hydrochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Phenazine - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Pyrazine - Benzenoid - Heteroaromatic compound - Tertiary amine - Azacycle - Amine - Hydrocarbon derivative - Organopnictogen compound - Primary amine - Organic nitrogen compound - Organonitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as phenazines and derivatives. These are polycyclic aromatic compounds containing a phenazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a pyrazine ring.
External Descriptors hydrochloride
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

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3 results found

Lot NumberCertificate TypeDateItem
J2308414Certificate of AnalysisSep 20, 2023 N131022
H2302732Certificate of AnalysisJul 19, 2023 N131022
B2309482Certificate of AnalysisDec 12, 2022 N131022
Chemical and Physical Properties
Melt Point(°C)290°C
Molecular Weight288.770 g/mol
XLogP3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass288.114 Da
Monoisotopic Mass288.114 Da
Topological Polar Surface Area55.000 Ų
Heavy Atom Count20
Formal Charge0
Complexity319.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Documents & Articles
Citations of This Product
References
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70. Qiuhui Qian, Qian Pu, Xin Li, XingCheng Liu, Anyu Ni, Xiaowen Han, Zejun Wang, Xuedong Wang, Jin Yan, Huili Wang.  (2024)  Acute/chronic triclosan exposure induces downregulation of m6A-RNA methylation modification via mettl3 suppression and elicits developmental and immune toxicity to zebrafish.  CHEMOSPHERE,      [PMID:38342143] [10.1016/j.chemosphere.2024.141395]
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75. Linglian Kong, Peng Sun, Xue Pan, Chuanpi Xiao, Bochen Song, Zhigang Song.  (2024)  Glycerol monolaurate regulates apoptosis and inflammation by suppressing lipopolysaccharide-induced ROS production and NF-κB activation in avian macrophages.  POULTRY SCIENCE,      [PMID:38851181] [10.1016/j.psj.2024.103870]
76. Wang Yi, Hu Yaozhong, Niu Zhenhua, Zhang Xuejiao, Fan Dancai, Ji Xuemeng, Lv Huan, Wang Shuo, Zhao Yanrong.  (2024)  Immunomodulation of nutritional formula containing epigallocatechin-3-gallate, ginseng extract, and polydextrose on inflammation and macrophage polarization.  Frontiers in Nutrition,      [PMID:38445210] [10.3389/fnut.2024.1370608]
77. Yunjin Yao, Zhongming Tao, Hongwei Hu, Lijie Zhang, Ziwei Ma, Yaoyao Wang, Shiyang Lin, Shaobin Wang.  (2024)  In situ growth of iron incorporated Ni3S2 nanosheet on nickel foam in mediating electron transfer to peroxymonosulfate for pollutant abatement.  Journal of Environmental Sciences,      [PMID:39306441] [10.1016/j.jes.2024.03.054]
78. Lei Ge, Jiaqi Li, Gaojing Du, Kai Sheng, Jingwei Hou, Binyu Zhou, Yatao Zhang, Bart Van der Bruggen, Junyong Zhu.  (2025)  Microporous Polyacylhydrazone Membranes with 3D Interconnected Nanochannels for Accurate Molecular Sieving.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202504997]
79. Xiaoyu Yang, Hongdan Wu, Zhihui Zhou, Yehao Zhao, Yuedong Li.  (2024)  Modification of a MoS2 composite membrane using nano-silica for high-efficiency dye separation.  NEW JOURNAL OF CHEMISTRY,  48  (16): (7439-7448).  [PMID:] [10.1039/D3NJ05932D]
80. Yunjin Yao, Wei Wang, Hongwei Hu, Lijie Zhang, Ziwei Ma, Shaobin Wang.  (2024)  Nickel–manganese sulfide on nickel foam toward highly efficient and stable potassium periodate activation for organic pollutant degradation.  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2024.120276]
81. Dandan Xie, Xiaochuan Yang, Hang Wang, Qiuxia Fu, Fayun Wei, Nuo Liu, Hailou Wang, Guangyu Zhang, Jiamu Dai, Chunhong Zhu, Wei Zhang.  (2024)  Non-destructive strategy to extract sustainable helix and high-strength Musa core fibers for rapid water conduction and evaporation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38734352] [10.1016/j.ijbiomac.2024.132276]
82. Jianming Wu, Shuai Chen, Qinjie Xu, Qingkai Pang, Peng Li, Yulin Li.  (2024)  Programable sewage-cleaning technology: Regenerating chitosan biofilms with anti-bacterial capacity via self-purification of water pollutants.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:38754677] [10.1016/j.ijbiomac.2024.132355]
83. Qian Lei, Yaoyu Zhang, Tongtong Yang, Lei Chen, Xinxin Pei, Yujie Zhang, Tengfei Ma, Yuzhu Xie, Yi Wang, Hongxia Li, Cheng Cao, Buchang Zhang, Changzhi Xu.  (2024)  Supplementation of dietary heptadecanoic acid enhances anti-Listeria monocytogenes response in macrophages.  Journal of Functional Foods,      [PMID:] [10.1016/j.jff.2024.106359]
84. Li Haiyang, Li Xiaran, Quan Fengyu, Chen Zhaojun, Xia Yanzhi, Xiong Zhong.  (2024)  Wide-Spectrum Dye Adsorption Performance of Alginic Acid Carbon Aerogel.  WATER AIR AND SOIL POLLUTION,  235  (6): (1-12).  [PMID:] [10.1007/s11270-024-07181-7]
85. Xingdi Zhao, Pengfei Bian, Liu Wang, Xinyu Li, Jingxin Zhou, Yuqing Qiao, Mingli Wang, Tifeng Jiao.  (2025)  SERS and photoelectric conversion properties of cholesterol derivatives composite Langmuir-Blodgett films with dyes.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2025.137741]
86. Tianyi Hu, Qun Liu, Zeng Xu, Zhengjiang Zhu, Wuyin Weng, Yucang Zhang.  (2025)  Antibacterial starch-cellulose-based films with pH-responsive colorimetric properties for real-time food freshness monitoring.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.166723]
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88. Xiaoyu Yang, Shunbi Xie, Weifen Wu, Jingwen Liu, Manjun Liao, Runzi Zhang, Yao Liu, Mengjun Wang, Yi He.  (2025)  Core-shell structure and twin-cone morphology of Au@Ag@HOF with efficient adsorption capability and high SERS enhancement efficiency for sensitive detection of bisphenol compounds in food.  FOOD CHEMISTRY,      [PMID:41027209] [10.1016/j.foodchem.2025.146522]
89. Hai-Chuan Yu, Meng-Yao Chen, Shuang-Ling Zhang, Fang-Chao Tong, Fan-Ping Wang, Lin Wang, Jia-Long Zhang, Jiao-Jie Guo, Bing-Yang Zhang, Jia-Qi Tian, Jiao Wu.  (2025)  LPS disrupts erythroid-myeloid balance in zebrafish via Jak2/Stat3-Hif1a signaling.  FISH & SHELLFISH IMMUNOLOGY,      [PMID:40935171] [10.1016/j.fsi.2025.110874]
90. Li Xiaran, Zhu Haishan, Zhang Yuke, Meng Ruiqi, Xiong Zhong, Xia Yanzhi.  (2023)  Magnetic Alginate Carbon Aerogel Adsorbents for Water-/Oil-Soluble Dyes.  WATER AIR AND SOIL POLLUTION,  234  (3): (1-12).  [PMID:] [10.1007/s11270-023-06203-0]
91. Huanzhao Liu, Pengxin Li, Yifan Wang, Huijie Wang, Yi Fang, Zhonglu Guo, Yang Huang, Jing Lin, Long Hu, Chengchun Tang, Zhenya Liu.  (2021)  Eco-green C, O co-doped porous BN adsorbent for aqueous solution with superior adsorption efficiency and selectivity.  CHEMOSPHERE,      [PMID:34634274] [10.1016/j.chemosphere.2021.132520]
92. Shizong Wang, Jianlong Wang.  (2024)  The correlation between electron exchange capacity of Fenton-like heterogeneous catalyst and catalytic activity.  CHEMOSPHERE,      [PMID:38494002] [10.1016/j.chemosphere.2024.141587]
93. Yunshuo Chen, Yachan Gong, Dan Li, Weiwei Feng, Yao Chen, Ting Zhao, Liuqing Yang, Guanghua Mao, Xiangyang Wu.  (2025)  Dinotefuran exposure induces immunotoxicity in zebrafish embryos.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,      [PMID:40222697] [10.1016/j.cbpc.2025.110206]
94. Xincong Su, Li Kai, Xiaowen Han, Rongzhi Wang, Xiao Yang, Xuedong Wang, Jin Yan, Qiuhui Qian, Zejun Wang, Huili Wang.  (2025)  Equipotent bisphenol S and bisphenol F with widely differing modes of action exhibit additive effects in immunotoxicity: insights based on intrinsic immunity, apoptosis and regeneration, and oxidative stress.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:40239502] [10.1016/j.scitotenv.2025.179405]
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96. Hongjuan Bai, Dan Liu, Gang Wang, Yuanyuan Feng, Xuanyan Zhu, Huiling Lu, Pengzhan Guo, Yifei Ding, Shuai Yang, Junhang Chen.  (2025)  A novel sulfonated polybenzothiazole-based adsorbent for simultaneous capture of organic dyes from aqueous solution.  SEPARATION SCIENCE AND TECHNOLOGY,      [PMID:] [10.1080/01496395.2025.2502749]
97. DongXue Ma, YuXin Zhang, Jia Zhang, Jun Shi, ShanHu Gao, Fei Long, Xin Wang, XingYu Pu, Jiayao Sun, Shuang Liang, Richard D. Cannon, Silas Villas-Boas, Ting-Li Han.  (2025)  Outer membrane vesicles derived from probiotic Escherichia coli Nissle 1917 promote metabolic remodeling and M1 polarization of RAW264.7 macrophages.  Frontiers in Immunology,      [PMID:40510339] [10.3389/fimmu.2025.1501174]
98. Dan Li, Xiaolong Li, Zijia Huang, Tengteng Liu, Mao Li, Xiaoming Chen, Na Li, Yong Zhao.  (2025)  A fluorescent fiber pH sensor for sensitive, wide-range detection using orange-emitting silicon quantum dots.  ANALYTICA CHIMICA ACTA,      [PMID:40670006] [10.1016/j.aca.2025.344330]
99. Xiongchao Liu, Xinyu Li, Na Gao, Zhiwei Liu, Yuangang Li, Mingli Wang, Tifeng Jiao.  (2025)  Langmuir-Blodgett composite films of amphiphilic perylene diimide and naphthalene diimide derivatives for acid-base gas sensing and surface-enhanced Raman scattering.  Sustainable Materials and Technologies,      [PMID:] [10.1016/j.susmat.2025.e01707]
100. Jun Zeng, Tao Jia, Tong Chen, Huilin Liu, Zhaojie Sun, Xiaoyong Huang, Yunfei Shang, Shuwei Hao, Chunhui Yang.  (2025)  Excitation-modulated upconversion nanoprobes for switchable imaging and phototherapy.  Applied Materials Today,      [PMID:] [10.1016/j.apmt.2025.102979]
101. Xiaoman Huang, Zixuan E, Hao Yang, Guihong Lai, Shuang Liu, Shujia Liao, Jiaqi Lin, Siyi Liu, Chen Long, Haoran Lin, Danqi Lu, Shuisheng Li, Yong Zhang.  (2025)  Immunological Characteristics of Triploid Grass Carp (Ctenopharyngodon idella) and evaluation of its phagocytosis in the macrophages of head kidney.  FISH & SHELLFISH IMMUNOLOGY,      [PMID:41205782] [10.1016/j.fsi.2025.110987]
102. Jie Song, Qian Pu, Chen Chen, Xingcheng Liu, Xinlei Zhang, Zejun Wang, Jin Yan, Xuedong Wang, Huili Wang, Qiuhui Qian.  (2025)  Neurological Outcomes of Joint Exposure to Polystyrene Micro/Nanospheres and Silver Nanoparticles in Zebrafish.  ENVIRONMENTAL HEALTH PERSPECTIVES,  133  (5): (057007).  [PMID:40138633] [10.1289/EHP14873]
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104. Yongfei Zhu, Jiayi Li, Shujuan Yu.  (2025)  Robust superhydrophilic/underwater superoleophobic cotton fabric decorated by β-FeOOH and PVA with excellent oil-water separation and photodegradation properties.  SEPARATION SCIENCE AND TECHNOLOGY,      [PMID:] [10.1080/01496395.2025.2595175]
105. Hui Ying Bai, Rui Hao Chen, Iek Man Lei, Zhi Jian Wang, Zi Liang Wu.  (2026)  Marangoni-Effect-Driven Locomotion of Patterned Gels with Evolved Shape Changes and Varied Motion Modes.  ACS Applied Materials & Interfaces,      [PMID:41555737] [10.1021/acsami.5c24354]
106. Qin Fang, Mengdie Qin, Ke-jun Tan.  (2026)  One-step synthesis of multicolor fluorescent carbon dots from neutral red for applications in LEDs and fingerprint detection.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2026.113695]
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