Animal Free,Carrier Free,Bioactive,ActiBioPure™,His Tag,PBS Only,≥95%(SDS-PAGE) ActiBioPure™,Animal Free,Bioactive,Carrier Free,His Tag,PBS Only for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining.
Description：
The neurotrophins, including NGF, BDNF, NT-3, and NT-4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to different members of the Trk family tyrosine kinase receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF, TrkB binds BDNF and NT‑4/5, and TrkC binds NT-3. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Natural splice variants of the different Trks, including TrkB variants lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described. The role of the different extracellular subdomains of TrkB in mediating neurotrophin binding and discrimination is currently being investigated. At the protein sequence level, human and rat TrkB are greater than 90% identical and the proteins exhibit cross-species activity. TrkB is primarily expressed in the nervous system. However, low levels of TrkB expression have also been observed in a wide variety of tissues (pancreas, kidneys, ovary) outside the nervous system.
Recombinant Human TrkB Protein (rp181612) - SDS-PAGE
3 μg/lane of Recombinant Human TrkB Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 54.2-80.0 kDa under reducing conditions and 49.9-74.0 kDa under non-reducing conditions.
Recombinant Human TrkB Protein (rp181612) - ELISA
Immobilized Recombinant Human TrkB Protein (rp181612) at 1.0 μg/mL can bind Rinat patent anti-TrkB (anti-TrkB) (Ab209857) with the EC50 of 34.2 ng/mL
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0606771 | Certificate of Analysis | Jun 14, 2024 | rp181612 |
| ZJ24F0606770 | Certificate of Analysis | Jun 14, 2024 | rp181612 |
| ZJ24F0606769 | Certificate of Analysis | Jun 14, 2024 | rp181612 |
| ZJ24F0606768 | Certificate of Analysis | Jun 14, 2024 | rp181612 |
| ZJ24R0500614 | Certificate of Analysis | Jun 02, 2024 | rp181612 |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Animal Free grade guide → View Carrier Free grade guide → View Bioactive grade guide → View ActiBioPure™ grade guide → View His Tag grade guide → View PBS Only grade guide →
