GRADE & PURITYAnimal Free?Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material.Carrier Free?Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays.Bioactive?Bioactive grade — verified to retain biological activity in functional assays. Use when the molecule must be functionally active, not just pure.ActiBioPure™?ActiBioPure™ — Aladdin's premier line for bioactive and recombinant products. Use when both high purity and preserved biological activity are required.His Tag?His tag grade — recombinant protein bearing a His tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein.Fc tag?Fc tag grade — recombinant protein bearing a Fc tag for affinity purification/detection. Use to purify, immobilize, or detect the tagged protein. The Fc tag aids dimerization and protein-A/G capture.≥90%(SDS-PAGE)
Expression System
HEK293
Accession #
Q61526
Protein Tag
C-hFc & His
Expression system
HEK293
Endotoxin Concentration
<0.1 EU/μg
Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse ErbB3/Her3 Protein (rp166491) at 2 μg/mL can bind Recombinant Human NRG1-beta1Protein, the ED50 for this effect is 60.44 ng/mL.
Animal Free,Carrier Free,Bioactive,ActiBioPure™,His-Tag,Fc tag,≥90%(SDS-PAGE) ActiBioPure™,Animal Free,Bioactive,Carrier Free,Fc tag,His Tag for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Avoid repeated freezing and thawing Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.
ActiBioPure™, Animal Free, Bioactive, Carrier Free, Fc tag, His Tag
Specifications & Purity
Animal Free, Carrier Free, Bioactive, ActiBioPure™, His-Tag, Fc tag, ≥90%(SDS-PAGE)
Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse ErbB3/Her3 Protein (rp166491) at 2 μg/mL can bind Recombinant Human NRG1-beta1Protein, the ED50 for this effect is 60.44 ng/mL.
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
Storage
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -20~-80℃ for more than 1 year. Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
Recombinant Mouse ErbB3/Her3 Protein (rp166491) - SDS-PAGE 2 μg/lane of Recombinant Mouse ErbB3/Her3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 125 kDa under reducing condition and 270 kDa under non-reducing condition.
Recombinant Mouse ErbB3/Her3 Protein (rp166491) - Protein Bioactivity Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse ErbB3/Her3 Protein (rp166491) at 2 μg/mL can bind Recombinant Human NRG1-beta1Protein, the ED₅₀ for this effect is 60.44 ng/mL.
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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