10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Hyoscyamine Hyoscyamine (Daturine) is an AChR inhibitor with IC50 of 7.5 nM.
In vitro
L-hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements. R-(+)-hyoscyamine results in displacement of [3H]NMS binding to the muscarinic acetylcholine receptor subtypes (m1-m5) with pKi value of 8.67, 8.51, 7.46, 8.56 and 8.53, respectively. Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells. S-(-)-hyoscyamine enhances the forskolin-stimulated synthesis of cyclic AMP in rat cardiac (both atrial and ventricular) membranes by up to 24%.
In vivo
L-hyoscyamine (20 mg/kg) prolongs migrating myoelectric complex (MMC) cycle length from 17.6 min to 29.0 min in conscious rats.
Cell Data
cell lines：Calu-6, PC-3, MDA-MA-231, SKOV-3, SW620, A549, A431, B16-F10(AP3) and Lewis Lung cells
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)[C@H](CO)C3=CC=CC=C3 |
|---|---|
| Molecular Weight | 289.37 |
| Reaxy-Rn | 91256 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=91256&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 E2318011 | Certificate of Analysis | Apr 03, 2026 | H407819 |
| 1. Yu Tian, Ling Liu, Chaochao Ma, Yuhan Chu, Shuang Jiang, Shen Jiang, Guangrun Wu, Wenchao Wu, Chunjuan Yang, Yunpeng Wang, Ting Zhang, Yan Fang, Yang Li. (2025) A sensitive quantitative method for drug concentrations in blood based on surface-enhanced Raman spectroscopy. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.114581] |
| 2. Baoxin Zhang, Jingqin Tian, Na Jiang, Guozhu Chai, Hong Quan, Xinghao Han, Hongjun Xie, Fangyuan Zhang, Zhihua Liao, Min Chen, Chao Wang, Xiaozhong Lan. (2025) Optimization of Tropane Alkaloids Extraction from Utilizing Response Surface Methodology and Quality Assessment through UPLC Fingerprinting. ACS Omega, 10 (25): (27137). [PMID:40621034] [10.1021/acsomega.5c02397] |
| 3. Yuxin Lin, Qian Jin, Yuanqing Chen, Jingyan Wang, Yi Zhang, Manzhu Cao, Jingjing Shi, Liqin Li. (2026) Targeting Glutamate Receptors with IEM-1925: A Strategy Against Soman-Induced Status Epilepticus and Neurodegeneration. NEUROTOXICOLOGY, [PMID:41520707] [10.1016/j.neuro.2026.103389] |
| 4. Ping Yuan, Jin Chen, Li Jiang. (2026) Notch signaling inhibition attenuates epileptogenesis and hippocampal damage without altering mossy fiber sprouting in adolescent rats post-status epilepticus. Frontiers in Molecular Neuroscience, [PMID:41847559] [10.3389/fnmol.2026.1764473] |
