STAT5-IN-2 - 10mM in DMSO , CAS No.2111834-61-6

CAS: 2111834-61-6 Cat. No.: S655921 Formula: C₂₆H₂₇N₃O Molecular Weight: 397.51 PubChem CID: 137628635

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

STAT5-IN-2 is a STAT5 inhibitor,STAT5-IN-2 has potent antileukemic effect

In Vitro

STAT5-IN-2 has EC 50 values of 9 μM and 5 μM in K562 and KU812 cells, respectively. STAT5-IN-2 (100 nM-50 µM; 48 hours) has EC 50 values of 2.6 µM and 3.5 µM in KG1a and MV-4-11 cells, respectively. STAT5-IN-2 (10 µM; 48 hours) induces apoptosis in all cell lines (K562, KU812, KG1a and MV-4-11 cells). STAT5-IN-2 (10 µM; 24 hours) blocks phosphorylation of STAT5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: KG1a and MV-4-11 cell lines Concentration: 100 nM, 10 µM, 20 µM, 30 µM, 40 µM, 50 µM Incubation Time: 48 hours Result: Inhibited cell growth in KG1a and MV-4-11 cell lines Apoptosis AnalysisCell Line: K562, KU812, KG1a and MV-4-11 cells Concentration: 10 µM Incubation Time: 48 hours Result: Significantly increased the number of apoptotic cells. Western Blot AnalysisCell Line: KG1a, MV-4-11 and KU812 cells Concentration: 10 µM Incubation Time: 24 hours Result: Inhibited phosphorylation of STAT5 compared to no influence on phosphorylation level of STAT3, Akt and Erk1/2.

IC50& Target:STAT5 9 μM (EC 50 , in K562 cells) STAT5 5 μM (EC 50 , in KU812 cells )

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

PubChem CID

137628635

Molecular Weight

397.51

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2111834-61-6, the molecular formula is C26H27N3O, and the molecular weight is 397.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.