Amivantamab (anti-c-Met) - Primary antibody, specific to MET, >95%, Human IgG1, Antibody of epidermal growth factor receptor;Antibody of MET proto-oncogene; receptor tyrosine kinase, Antibody of epidermal growth factor receptor;Antibody of MET proto-oncogene; receptor tyrosine kinase

CAS: 2171511-58-1 Cat. No.: Ab175451
Disponible para pedir
GRADE & PURITY Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. ≥95%(SDS-PAGE&SEC-HPLC) See COA
Application
Animal Model, ELISA, Flow Cytometry, Functional Assay
Host species
Human
Reactive species
Human, Mouse
Isotype
Human IgG1
Conjugation
Unconjugated
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
100μg
Ab175451-100μg
10
143,90US$
1mg
Ab175451-1mg
2
719,90US$
5mg
Ab175451-5mg
1
1.625,90US$
10mg
Ab175451-10mg
1-2 wks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
2.599,90US$
Enter a quantity for the sizes you want to add.
🧪

Why this grade

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA Animal Free,Azide Free,Carrier Free,ExactAb™,Low Endotoxin,Recombinant,Validated for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -80°C,Avoid repeated freezing and thawing Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Amivantamab (anti-c-Met) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab (anti-c-Met) inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells.

Specifications

Product Name
Amivantamab (anti-c-Met) - Primary antibody, specific to MET, >95%, Human IgG1, Antibody of epidermal growth factor receptor;Antibody of MET proto-oncogene; receptor tyrosine kinase
Sinónimos
AUTS9 antibody | c met antibody | D249 antibody | Hepatocyte growth factor receptor antibody | HGF antibody | HGF receptor antibody | HGF/SF receptor antibody | HGFR antibody | MET antibody | Met proto oncogene antibody | Met proto oncogene tyrosine kinas
Especificaciones y pureza
Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Especies hospedadoras
Human
Especificidad
MET
Conjugación
Unconjugated
Grado
Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Tipo de acción
INHIBITOR
Mecanismo de acción
Antibody of epidermal growth factor receptor;Antibody of MET proto-oncogene; receptor tyrosine kinase
Isotipo
Human IgG1
Tipo de cadena ligera
kappa
SDS-PAGE
26.8 kDa (Light Chain) & 50.9 kDa (Heavy Chain), under reducing conditions; 176.1 kDa, under non-reducing conditions.
Método de purificación
Protein A purified
Pureza
>95%
Concentración
See COA
CAS
2171511-58-1
Almacenamiento y envío
Forma
Liquid
Condiciones de almacenamiento de almacenamiento
Store at -80°C,Avoid repeated freezing and thawing
Enviado en
Dry ice packs + Cold packs
Estabilidad y almacenamiento
Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
Imágenes

Amivantamab (anti-c-Met) (Ab175451) - Flow Cytometry
Flow Cytometry analysis of HepG2 cells labelling c-Met (red) with Amivantamab (anti-c-Met) (Ab175451). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Amivantamab (anti-c-Met) (Ab175451) - Flow Cytometry
Flow Cytometry analysis of MDA-MB-231 cells labelling c-Met (red) with Amivantamab (anti-c-Met) (Ab175451). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Amivantamab (anti-c-Met) (Ab175451) - SEC
The purity of Amivantamab (anti-c-Met) (Ab175451) is more than 95% verified by HPLC.

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Objetivos asociados (humanos)
EGFR Tclin Epidermal growth factor receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MET Tclin Hepatocyte growth factor receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MET Tclin Hepatocyte growth factor receptor (10718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin MER intracellular domain/EGFR extracellular domain chimera (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Protein cereblon/Epidermal growth factor receptor (191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin EGFR/PPP1CA (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin VHL/EGFR (323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeFechaArticulo
ZJ24F0910006Certificate of AnalysisJun 23, 2026 Ab175451
ZJ24F0910007Certificate of AnalysisJun 23, 2026 Ab175451
ZJ24F0910008Certificate of AnalysisJun 23, 2026 Ab175451
Citations of This Product
Referencias
1. Lianbao Ye, Yuanxin Tian, Zhonghuang Li, Hong Jin, Zhengguang Zhu, Shanhe Wan, Junyan Zhang, Pengjiu Yu, Jiajie Zhang, Shuguang Wu.  (2012)  Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4′-piperidine]-2-ones as potential c-Met inhibitors.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:22381355] [10.1016/j.ejmech.2012.02.016]
2. Lianbao Ye, Xiaomin Ou, Yuanxin Tian, Bangwei Yu, Yan Luo, Binghong Feng, Hansen Lin, Jiajie Zhang, Shuguang Wu.  (2013)  Indazoles as potential c-met inhibitors: Design, synthesis and molecular docking studies.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:23702473] [10.1016/j.ejmech.2013.04.004]
Calculadoras de soluciones
Reseñas

Reseñas de cliente

Need help choosing the grade?

Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.

View Animal Free grade guide → View Carrier Free grade guide → View Recombinant grade guide → View Validated grade guide → View ExactAb™ grade guide → View Low Endotoxin grade guide → View Azide Free grade guide →

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