CD243/MDR1 Mouse mAb (Biotin) - Primary antibody, specific to P Glycoprotein/CD243

Cat. No.: Ab211170

GRADE & PURITY Validated, ExactAb™, 0.5 mg/mL

Application

Flow Cytometry

Host species

Mouse

Reactive species

Human, Monkey

Isotype

Mouse IgG2a

Clone Number

UIC2

Conjugation

Biotin

Descripción general

Mouse anti Human/Monkey CD243/MDR1 Antibody, Monoclonal (UIC2), could be used for in vivo MDR-1 blocking/depletion in xenogeneic murine tumor models, in vitro MDR-1 blocking, IHC, Flow and so on.

Specifications

Product Name

CD243/MDR1 Mouse mAb (Biotin) - Primary antibody, specific to P Glycoprotein/CD243

Sinónimos

CLCS | MDR1 | P-GP | PGY1 | ABC20 | CD243 | GP170 | p-170 | ABC20 antibody | ABCB1 antibody | ATP binding cassette, sub family B (MDR/TAP), member 1 antibody | ATP-binding cassette sub-family B member 1 antibody | CD243 antibody | CLCS antibody | Colchici

Especificaciones y pureza

ExactAb™, Validated, 0.5 mg/mL

Mecanismos bioquímicos y fisiológicos

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Especies hospedadoras

Mouse

Especificidad

P Glycoprotein/CD243

Inmunógeno

3T3 fibroblasts transfected with human CD243 cDNA

Control positivo

Flow: HepG2 cells

Conjugación

Biotin

Grado

ExactAb™, Validated

Tipo de cadena ligera

kappa

Método de purificación

Protein A purified

Concentración

0.5 mg/mL

Almacenamiento y envío

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C,Protected from light,Do not freeze

Enviado en

Wet ice,Do not freeze

Estabilidad y almacenamiento

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Imágenes

Flow Cytometry: CD243/MDR1 Mouse mAb (Biotin) (Ab211170)

CD243/MDR1 Mouse mAb (Biotin) (Ab211170) - Flow Cytometry
Flow cytometry analysis of CD243/MDR1 expression by HepG2 cells (red) compared to an isotype control (blue). Cells were stained with CD243/MDR1 Mouse mAb (Biotin) (Ab211170) at 1.0 μg/test for 1 hour at 4°C. Then incubated with Recombinant Streptavidin Protein (R-PE) (rp156150) at 0.1μg/test for 30 minutes at 4°C in the dark. Blue - Mouse IgG (Biotin) (Ab180306). Black - Unlabelled control, cells without incubation with primary antibody.

Aplicación

• Aplicación: Dilution info
• Flow Cytometry:

  ≤1.0 μg/test, the suggested use of this reagent is ≤1.0 μg per million cells in 100 µL staining volume ;

Objetivos asociados (humanos)

ABCB1 Tchem Multidrug resistance protein 1 (0 Activities)

Discover Target: ABCB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)