Cemiplimab (anti-PD-1) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to PDCD1, >95%, Human IgG4, Antibody of programmed cell death 1 (CD279), Antibody of programmed cell death 1 (CD279)

CAS: 1801342-60-8 Cat. No.: C412010

GRADE & PURITY Animal Free, Carrier Free, Recombinant, Validated, ExactAb™, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Human

Isotype

Human IgG4

Conjugation

Unconjugated

Descripción general

Cemiplimab is a monoclonal IgG4 antibody with high affinity for programmed death receptor-1 (PD-1) that blocks PD-1/PD-L1 mediated T cell inhibition. It is commonly used in squamous cell skin cancer research.

Specifications

Product Name

Cemiplimab (anti-PD-1) - Primary antibody, for ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR),Flow Cyt various applications, specific to PDCD1, >95%, Human IgG4, Antibody of programmed cell death 1 (CD279)

Sinónimos

hPD-1 | Protein PD-1

Especificaciones y pureza

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Especies hospedadoras

Human

Especificidad

PDCD1

Aplicación

ELISA, Functional Assay, Kinetics (BLI), Kinetics (SPR), Flow Cyt

Conjugación

Unconjugated

Grado

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Tipo de acción

INHIBITOR

Mecanismo de acción

Antibody of programmed cell death 1 (CD279)

Tipo de anticuerpo

Primary antibody

Clonalidad

Recombinant

Isotipo

Human IgG4

Tipo de cadena ligera

kappa

SDS-PAGE

26.0 kDa (Light Chain) & 49.9 kDa (Heavy Chain), under reducing conditions; 169.6 kDa, under non-reducing conditions.

Método de purificación

Protein A purified

Pureza

>95%

Fuente

CHO supernatant

Concentración

See COA

CAS

1801342-60-8

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -80°C,Avoid repeated freezing and thawing

Enviado en

Dry ice packs + Cold packs

Estabilidad y almacenamiento

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imágenes

ELISA: Cemiplimab (anti-PD-1) (C412010)

Cemiplimab (anti-PD-1) (C412010) - ELISA
Immobilized hu-PD-1 at 2 μg/mL can bind Cemiplimab (anti-PD-1) (C412010) with the EC₅₀ of 8.66 ng/mL.

SEC: Cemiplimab (anti-PD-1) (C412010)

Cemiplimab (anti-PD-1) (C412010) - SEC
The purity of Cemiplimab (anti-PD-1) (C412010) is more than 95% verified by HPLC.

ELISA: Cemiplimab (anti-PD-1) (C412010)

Cemiplimab (anti-PD-1) (C412010) - ELISA
Immobilized Recombinant Human PD-1 Protein (rp176241) at 1.0 μg/mL can bind Cemiplimab (anti-PD-1) (C412010) with the EC50 of 12.82 ng/mL.

Objetivos asociados (humanos)

PDCD1 Tclin Programmed cell death protein 1 (0 Activities)

Discover Target: PDCD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDCD1 Tclin Programmed cell death protein 1 (14 Activities)

Discover Target: PDCD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Referencias

1. Gao Hengyuan, Lin Junqing, Chen Xiaobing, Su Yingshi, Huang Yibin, Zhang Yubo, Zhang Junchang, Xu Nan, Dai Xiaoyong.  (2026)  Microfluidic-based patient-derived organoids recapitulate thyroid cancer heterogeneity and reveal NF-κB-driven maturation for precision therapy.  Journal of Translational Medicine,      [PMID:41761289] [10.1186/s12967-026-07882-z]