Cytochrome P450 2E1 Antibody - Primary antibody, specific to CYP2E1, Rabbit IgG

Cat. No.: Ab098732

GRADE & PURITY Carrier Free, See COA

Application

IHC, WB

Host species

Rabbit

Reactive species

Human, Mouse, Rat

Isotype

Rabbit IgG

Conjugation

Unconjugated

Descripción general

Rabbit anti Human Cytochrome P450 2E1 Antibody, Polyclonal antibody, could be used for WB, IHC and so on.

Specifications

Product Name

Cytochrome P450 2E1 Antibody - Primary antibody, specific to CYP2E1, Rabbit IgG

Sinónimos

4-nitrophenol 2-hydroxylase | CP2E1_HUMAN | CPE 1 | CPE1 | CYP2E | CYP2E1 | CYPIIE1 | Cytochrome P450 2E1 | cytochrome P450 family 2 subfamily E polypeptide 1 | Cytochrome P450 isozyme 3A | Cytochrome P450 LM3A | Cytochrome P450 subfamily IIE (ethanol ind

Especificaciones y pureza

Carrier Free, See COA

Mecanismos bioquímicos y fisiológicos

Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Especies hospedadoras

Rabbit

Especificidad

CYP2E1

Inmunógeno

A synthetic peptide derived from human CYP2E1

Control positivo

WB: Mouse liver, kidney lysates.  IHC: Human liver, colorectal cancer tissues

Conjugación

Unconjugated

Grado

Carrier Free

Isotipo

Rabbit IgG

SDS-PAGE

150 kDa

Método de purificación

Antigen affinity purified

Concentración

See COA

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Avoid repeated freezing and thawing

Enviado en

Ice chest + Ice pads

Estabilidad y almacenamiento

Store at 2-8℃ short term (1-2 weeks). Store at -20℃ long term (12 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Aplicación

• Aplicación: Dilution info
• IHC:

  1/50-1/200;

• WB:

  1/1000-1/5000 ;

Objetivos asociados (humanos)

CYP2E1 Tchem Cytochrome P450 2E1 (0 Activities)

Discover Target: CYP2E1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de acción

Referencias

1. Yunqi Li, Yuan He, Ting Shao, Haixiang Pei, Weikai Guo, Dazhao Mi, Isabelle Krimm, Yuanjin Zhang, Peili Wang, Xin Wang, Mingyao Liu, Zhengfang Yi, Yihua Chen.  (2019)  Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:31026162] [10.1021/acs.jmedchem.9b00059]

2. Jun-Jie Yang, Wei-Wei Yu, Long-Long Hu, Wen-Juan Liu, Xian-Hua Lin, Wei Wang, Qiansen Zhang, Pei-Li Wang, Shuo-Wen Tang, Xin Wang, Mingyao Liu, Weiqiang Lu, Han-Kun Zhang.  (2019)  Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:31855426] [10.1021/acs.jmedchem.9b01269]