Integrin beta 3/CD61 Mouse mAb - Primary antibody, specific to Integrin beta 3, Mouse IgG1

Cat. No.: Ab110877

GRADE & PURITY Carrier Free, Validated, ExactAb™, See COA

Application

Flow Cytometry

Host species

Mouse

Reactive species

Human

Isotype

Mouse IgG1

Clone Number

HIP11

Conjugation

Unconjugated

Descripción general

Mouse anti Human Integrin beta 3/CD61 Antibody, Monoclonal (HIP11), could be used for Flow and so on.
Application:
Flow:＜0.5 µg/100w cells
Protein Function
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Specifications

Product Name

Integrin beta 3/CD61 Mouse mAb - Primary antibody, specific to Integrin beta 3, Mouse IgG1

Sinónimos

BDPLT16 | BDPLT2 | BDPLT24 | GPIIIa | GT | GT2 | CD61 antigen | CD61 | GP3A | GP3Aplatelet glycoprotein IIIa | GPIIIaintegrin beta-3 | INGRB3 | Integrin beta 3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | ITG B3 | ITGB3 | Platelet membr

Especificaciones y pureza

Carrier Free, ExactAb™, Validated, See COA

Especies hospedadoras

Mouse

Especificidad

Integrin beta 3

Inmunógeno

Normal peripheral blood platelets and platelets from IPT patients

Control positivo

Flow: Human peripheral blood lymphocytes.

Conjugación

Unconjugated

Grado

Carrier Free, ExactAb™, Validated

Isotipo

Mouse IgG1

Tipo de cadena ligera

kappa

SDS-PAGE

150 kDa

Método de purificación

Protein A purified

Concentración

See COA

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Estabilidad y almacenamiento

Shipped at 4°C. Store at 4°C long term (36 months). Upon receipt, it is recommended to aliquot.

Imágenes

Flow Cytometry: Integrin beta 3/CD61 Mouse mAb (Ab110877)

Integrin beta 3/CD61 Mouse mAb (Ab110877) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood platelets labelling Integrin beta 3/CD61 (red) with Integrin beta 3/CD61 Mouse mAb (Ab110877) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) (Ab179006) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

Aplicación

• Aplicación: Dilution info
• Flow:

  < 0.5µg/100w cells;

Objetivos asociados (humanos)

ITGB3 Tclin Integrin beta-3 (0 Activities)

Discover Target: ITGB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGB3 Tclin Integrin alpha-V/beta-3 (2708 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGB3 Tclin Integrin alpha-IIb/beta-3 (3481 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGB3 Tclin Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) (39 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGB3 Tclin Integrin alpha-V/beta-3 and alpha-IIb/beta 3 (49 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGB3 Tclin Integrin alpha-2/beta-3 (21 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGB3 Tclin Integrin alpha-3/beta-3 (47 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción