PERK

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  1. Inhibidor de PERK de GSK, Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 3;Inhibitor of myosin light chain kinase 2
    CAS: 1337531-89-1 Fórmula: C24H19F4N5O Peso molecular: 469.43
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — EE. UU. Articulo #: G355474
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    Nombre IUPAC
    1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone
    SMILES
    CN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC(=C5)F)C(F)(F)F
    InChIKey
    PXVQGBJMIQCDEX-UHFFFAOYSA-N
    InChI
    1S/C24H19F4N5O/c1-32-11-18(21-22(29)30-12-31-23(21)32)14-2-3-19-15(9-14)4-5-33(19)20(34)8-13-6-16(24(26,27)28)10-17(25)7-13/h2-3,6-7,9-12H,4-5,8H2,1H3show more
    Sinónimos
    1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2, 3-dihydroindol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]eth...
  2. GSK2606414
    CAS: 1337531-36-8 Fórmula: C24H20F3N5O Peso molecular: 451.44
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — EE. UU. Articulo #: G125654
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    Nombre IUPAC
    1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone
    SMILES
    CN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F
    InChIKey
    SIXVRXARNAVBTC-UHFFFAOYSA-N
    InChI
    1S/C24H20F3N5O/c1-31-12-18(21-22(28)29-13-30-23(21)31)15-5-6-19-16(11-15)7-8-32(19)20(33)10-14-3-2-4-17(9-14)24(25,26)27/h2-6,9,11-13H,7-8,10H2,1H3,(Hshow more
    Sinónimos
    AC-29016 | 1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone...
  3. GSK2656157, Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 3
    CAS: 1337532-29-2 Fórmula: C23H21FN6O Peso molecular: 416.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — EE. UU. Articulo #: G276179
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    Nombre IUPAC
    1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone
    SMILES
    CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=NC=NC(=C45)N)C
    InChIKey
    PRWSIEBRGXYXAJ-UHFFFAOYSA-N
    InChI
    1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,2show more
    Sinónimos
    1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)e...
  4. ONO 8130, Antagonist of EP 1 receptor
    CAS: 459841-96-4 Fórmula: C25H28N2O5S2 Peso molecular: 500.63
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ◐ .Fabricado bajo pedido · 8–12 semanas Articulo #: O287851
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    Nombre IUPAC
    4-[[6-[2-methylpropyl-[(4-methyl-1,3-thiazol-2-yl)sulfonyl]amino]-2,3-dihydro-1H-inden-5-yl]oxymethyl]benzoic acid
    SMILES
    CC1=CSC(=N1)S(=O)(=O)N(CC(C)C)C2=C(C=C3CCCC3=C2)OCC4=CC=C(C=C4)C(=O)O
    InChIKey
    IOXMDBQCUCDLAF-UHFFFAOYSA-N
    InChI
    1S/C25H28N2O5S2/c1-16(2)13-27(34(30,31)25-26-17(3)15-33-25)22-11-20-5-4-6-21(20)12-23(22)32-14-18-7-9-19(10-8-18)24(28)29/h7-12,15-16H,4-6,13-14H2,1-3show more
    Sinónimos
    AC-36636 | BDBM190564 | 4-[[6-[2-methylpropyl-[(4-methyl-1,3-thiazol-2-yl)sulfonyl]amino]-2,3-dihydro-1H-inden-5-yl]o...
  5. VU 0424465, Agonist of mGlu 5 receptor;Allosteric modulator of mGlu 5 receptor
    CAS: 1428630-85-6 PubChem CID: 53384864 Fórmula: C19H19FN2O2 Peso molecular: 326.37
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ◐ .Fabricado bajo pedido · 8–12 semanas Articulo #: V286883
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    Nombre IUPAC
    5-[2-(3-fluorophenyl)ethynyl]-N-[(2R)-3-hydroxy-3-methylbutan-2-yl]pyridine-2-carboxamide
    SMILES
    CC(C(C)(C)O)NC(=O)C1=NC=C(C=C1)C#CC2=CC(=CC=C2)F
    InChIKey
    ZPKZAFDYFVJULO-CYBMUJFWSA-N
    InChI
    1S/C19H19FN2O2/c1-13(19(2,3)24)22-18(23)17-10-9-15(12-21-17)8-7-14-5-4-6-16(20)11-14/h4-6,9-13,24H,1-3H3,(H,22,23)/t13-/m1/s1
    Sinónimos
    5-[2-(2-(3-Fluorophenyl)ethynyl]-N-[(1R)-2-hydroxy-1,2-dimethylpropyl]-2-pyridinecarboxamide
  6. AMG PERK 44
    CAS: 1883548-84-2 Fórmula: C34H28N4O2•HCl Peso molecular: 561.07
    ● En stock — EE. UU. Articulo #: A286749
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    Nombre IUPAC
    4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one;hydrochloride
    SMILES
    CC1=C(C(=C(C=C1)C(=O)C2=C(N(N(C2=O)C3=CC=CC=C3)C)C4=CC=CC=C4)N)C5=CC6=C(C=C5)N=C(C=C6)C.Cl
    InChIKey
    RNAKBTDDCHJCMT-UHFFFAOYSA-N
    InChI
    1S/C34H28N4O2.ClH/c1-21-14-18-27(31(35)29(21)25-17-19-28-24(20-25)16-15-22(2)36-28)33(39)30-32(23-10-6-4-7-11-23)37(3)38(34(30)40)26-12-8-5-9-13-26;/hshow more
    Sinónimos
    4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride
  7. NSC 295642
    CAS: 77111-29-6 Fórmula: C15H14ClCuN3S2 Peso molecular: 399.42
    ◐ .Fabricado bajo pedido · 8–12 semanas Articulo #: N352361
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    Nombre IUPAC
    (E)-benzylsulfanyl-[(E)-1-pyridin-2-ylethylidenehydrazinylidene]-sulfidomethane;chlorocopper(1+)
    SMILES
    CC(=NN=C([S-])SCC1=CC=CC=C1)C2=CC=CC=N2.Cl[Cu+]
    InChIKey
    MGXCRQNCPJBYKM-CWQUOYFRSA-L
    InChI
    1S/C15H15N3S2.ClH.Cu/c1-12(14-9-5-6-10-16-14)17-18-15(19)20-11-13-7-3-2-4-8-13;;/h2-10H,11H2,1H3,(H,18,19);1H;/q;;+2/p-2/b17-12+;;
    Sinónimos
    (E)-benzylsulfanyl-[(E)-1-pyridin-2-ylethylidenehydrazinylidene]-sulfidomethane;chlorocopper(1+) | DTXSID20444568 | N...
  8. ISRIB (trans-isomer)
    CAS: 1597403-47-8 Fórmula: C22H24Cl2N2O4 Peso molecular: 451.34
    ● En stock — EE. UU. Articulo #: I275318
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    Nombre IUPAC
    2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
    SMILES
    C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
    InChIKey
    HJGMCDHQPXTGAV-UHFFFAOYSA-N
    InChI
    1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,2show more
    Sinónimos
    ISRIB | ISRIB trans-isomer | BCP23947 | ISRIB, >=98% (HPLC) | N,N'-(Cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)aceta...
  9. S-(Carboxymethyl)-L-cysteine
    CAS: 638-23-3 PubChem CID: 193653 Fórmula: C5H9NO4S Peso molecular: 179.19
    ● En stock — EE. UU. Articulo #: S161422
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    Nombre IUPAC
    (2R)-2-amino-3-(carboxymethylsulfanyl)propanoic acid
    SMILES
    N[C@@H](CSCC(O)=O)C(O)=O
    InChIKey
    GBFLZEXEOZUWRN-VKHMYHEASA-N
    InChI
    1S/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
    Sinónimos
    Carbocysteine, L Isomer | Chilvax | Mucodyne | (2R)-2-amino-3-(carboxymethylsulfanyl)propanoic acid | (2R)-2-amino-3-...
  10. Obestatin human(trifluoroacetate salt)
    CAS: 1081110-72-6 PubChem CID: 146156385 Fórmula: C116H176N32O33(free basis) Peso molecular: 2546.86(free basis)
    ● En stock — EE. UU. Articulo #: O287703
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    Nombre IUPAC
    4-[[1-[[2-[[1-[[6-amino-1-[[1-[[1-[[2-[[1-[[5-amino-1-[[1-[[5-amino-1-[[5-amino-1-[[1-[[1-[[5-amino-1-[[1-[(1-amino-4-methyl-1-oxopentan-2-yl)amino]-1show more
    SMILES
    CCC(C)C(C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NCC(=O)NC(C(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)Nshow more
    InChIKey
    IXQOGPZNKNSCJR-UHFFFAOYSA-N
    InChI
    1S/C116H176N32O33/c1-13-61(10)95(146-91(158)53-127-113(178)93(59(6)7)147-110(175)81(50-92(159)160)141-108(173)78(46-65-25-18-15-19-26-65)142-112(177)8show more
  11. GSK2656157, Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 3
    CAS: 1337532-29-2 Fórmula: C23H21FN6O Peso molecular: 416.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● En stock — EE. UU. Articulo #: G421276
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    Nombre IUPAC
    1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone
    SMILES
    CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=NC=NC(=C45)N)C
    InChIKey
    PRWSIEBRGXYXAJ-UHFFFAOYSA-N
    InChI
    1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,2show more
    Sinónimos
    1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)e...
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Preguntas frecuentes

How is the PERK listing put together?
It draws on reported PERK annotations within Cell Cycle/DNA Damage and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose a PERK modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the PERK entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for PERK compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For PERK work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the PERK compound I need is not listed?
Search by CAS number or SMILES first, since analogs of PERK compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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