Antifolato

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  1. Levomefolate calcium
    CAS: 151533-22-1 Fórmula: C20H23CaN7O6 Peso molecular: 497.52
    ● En stock — EE. UU. Articulo #: L302964
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    Nombre IUPAC
    calcium;(2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
    SMILES
    CN1C(CNC2=C1C(=O)NC(=N2)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Ca+2]
    InChIKey
    VWBBRFHSPXRJQD-QNTKWALQSA-L
    InChI
    1S/C20H25N7O6.Ca/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29;/h2-5,12-13,22H,6-9H2,1H3,(H,24,3show more
    Sinónimos
    CALCIUM L-5-METHYLTETRAHYDROFOLATE [DSC] | Rhenium, wire reel, 0.2m, diameter 0.076mm, annealed, 99.97% | BAY86-7660 ...
  2. Folinic acid, calcium salt pentahydrate
    CAS: 6035-45-6 Fórmula: C20H21CaN7O7.5H2O Peso molecular: 601.59
    ● En stock — EE. UU. Articulo #: F304111
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    Nombre IUPAC
    calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate;pentahydrate
    SMILES
    C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2]
    InChIKey
    NPPBLUASYYNAIG-ZIGBGYJWSA-L
    InChI
    1S/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-show more
    Sinónimos
    CALCII FOLINAS [WHO-IP LATIN] | 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N,beta-trimethyl-, (+)-, (Z)-2-b...
  3. 10-Formyl Folic Acid
    CAS: 134-05-4 Fórmula: C20H19N7O7 Peso molecular: 469.41
    ● En stock — EE. UU. Articulo #: F334434
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    Nombre IUPAC
    (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
    SMILES
    C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)N(CC2=CN=C3C(=N2)C(=O)NC(=N3)N)C=O
    InChIKey
    UGWUWNVTCLDEOG-ZDUSSCGKSA-N
    InChI
    1S/C20H19N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,7,9,13H,5-6,8H2,(H,24,31)(H,show more
    Sinónimos
    10-Formylpteroylglutamic Acid | 10-Formyldihydropteroylglutamate | L-GLUTAMIC ACID, N-(4-(((2-AMINO-3,4-DIHYDRO-4-OXO...
  4. Pemetrexed, Inhibitor of dihydrofolate reductase;Inhibitor of phosphoribosylglycinamide formyltransferase; phosphoribosylglycinamide synthetase; phosphoribosylaminoimidazole synthetase;Inhibitor of thymidylate synthetase
    CAS: 137281-23-3 Número EC: 680-625-9 Fórmula: C20H21N5O6 Peso molecular: 427.41
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — EE. UU. Articulo #: P125303
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    Nombre IUPAC
    (2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
    SMILES
    C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
    InChIKey
    WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
    InChI
    1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(show more
    Sinónimos
    GTPL5443 | N-({4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]phenyl}carbonyl)-L-glutamic acid...
  5. Pemetrexed, GAR transformylase inhibitor
    CAS: 150399-23-8 Fórmula: C20H19N5Na2O6 Peso molecular: 471.37
    ● En stock — EE. UU. Articulo #: P129841
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    Nombre IUPAC
    disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
    SMILES
    C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
    InChIKey
    NYDXNILOWQXUOF-GXKRWWSZSA-L
    InChI
    1S/C20H21N5O6.2Na/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,2show more
    Sinónimos
    CAS-150399-23-8 | Pemetrexed Disodium is known as a Thymidylate synthase inhibitor. | PEMETREXED DISODIUM [USP MONOGR...
  6. Trimethoprim
    CAS: 738-70-5 Número EC: 212-006-2 PubChem CID: 5578 Fórmula: C14H18N4O3 Peso molecular: 290.32
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● En stock — EE. UU. Articulo #: T129928
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    Nombre IUPAC
    5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
    SMILES
    COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
    InChIKey
    IEDVJHCEMCRBQM-UHFFFAOYSA-N
    InChI
    1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
    Sinónimos
    5-(3,4,5-Trimethoxybenzyl)-2,4-diaminopyrimidine | Resprim | Bactoprim | Espectrin | Purbal | Roubal | Streptoplus | ...
  7. Pemetrexed disodium hydrate
    CAS: 357166-30-4 Número EC: 604-733-2, 814-356-7 PubChem CID: 135564527 Fórmula: C20H21N5O6·5/2H2O·2Na Peso molecular: 516.42
    ● En stock — EE. UU. Articulo #: P140269
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    Nombre IUPAC
    tetrasodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate;pentahydrate
    SMILES
    C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Na+show more
    InChIKey
    ZCTCZKWJFTYNMZ-WKUCUCPSSA-J
    InChI
    1S/2C20H21N5O6.4Na.5H2O/c2*21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h2*1-2,4-5,9,13H,3,6-show more
    Sinónimos
    UNII-F4GSH45R4C | Pemetrexed accord | (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)be...
  8. Aminopterin Hydrate
    CAS: 54-62-6 Número EC: 200-209-9 Fórmula: C19H20N8O5·xH2O Peso molecular: 440.41(as Anhydrous)
    ● En stock — EE. UU. Articulo #: A107171
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    Nombre IUPAC
    (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
    SMILES
    Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
    InChIKey
    TVZGACDUOSZQKY-LBPRGKRZSA-N
    InChI
    1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(show more
    Sinónimos
    CAS-54-62-6 | Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)amino)benzoyl)-L(+)-glutamova | (2S)-2-[[4-[[(2,4-Diamin...
  9. Pralatrexate, Dihydrofolate reductase inhibitor
    CAS: 146464-95-1 Fórmula: C23H23N7O5 Peso molecular: 477.47
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● En stock — EE. UU. Articulo #: P125726
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    Nombre IUPAC
    (2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid
    SMILES
    C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
    InChIKey
    OGSBUKJUDHAQEA-WMCAAGNKSA-N
    InChI
    1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,2show more
    Sinónimos
    (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]phenyl}formamido)pentanedioic acid | CHEBI:39196 | (2S)-2-((4-...
  10. 7-Bromo-2,4-diaminoquinazoline
    CAS: 137553-43-6 Fórmula: C8H7BrN4 Peso molecular: 239.07
    ● En stock — EE. UU. Articulo #: B181364
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    Nombre IUPAC
    7-bromoquinazoline-2,4-diamine
    SMILES
    C1=CC2=C(C=C1Br)N=C(N=C2N)N
    InChIKey
    YPWBLOIRVSSESG-UHFFFAOYSA-N
    InChI
    1S/C8H7BrN4/c9-4-1-2-5-6(3-4)12-8(11)13-7(5)10/h1-3H,(H4,10,11,12,13)
    Sinónimos
    DHFR-IN-3 | GS-4262 | 2,4-Quinazolinediamine, 7-bromo- | DTXSID20160236 | J-007040 | SY032047 | 7-Bromo-2,4-diaminoqu...
  11. Folinic acid calcium salt hydrate
    CAS: 1492-18-8 Fórmula: C20H21CaN7O7 · xH2O Peso molecular: 511.50 (anhydrous basis)
    Solid ≥98%
    ● En stock — EE. UU. Articulo #: F107310
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    Nombre IUPAC
    calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
    SMILES
    [Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13
    InChIKey
    KVUAALJSMIVURS-ZEDZUCNESA-L
    InChI
    1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,show more
    Sinónimos
    AMPHOTERICIN B (USP-RS) | Calcii folinas | BUDESONIDE COMPONENT OF BREZTRI | Calcifolin | Folinac | Leucovorin calciu...
  12. Diaveridine
    CAS: 5355-16-8 Número EC: 226-333-3 Fórmula: C13H16N4O2 Peso molecular: 260.29
    ● En stock — EE. UU. Articulo #: D137262
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    Identificadores técnicos
    Nombre IUPAC
    5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
    SMILES
    COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC
    InChIKey
    LDBTVAXGKYIFHO-UHFFFAOYSA-N
    InChI
    1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17)
    Sinónimos
    CCG-213021 | 2, 5-[(3,4-dimethoxyphenyl)methyl]- | Diaveridina | EN300-7440332 | 5-[(3,4-dimethoxyphenyl)methyl]pyrim...
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Preguntas frecuentes

How is the Antifolate listing put together?
It draws on reported Antifolate annotations within Cell Cycle/DNA Damage and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.
How do I choose an Antifolate modulator for my assay?
Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the Antifolate entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.
Which specifications matter most for Antifolate compounds?
Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For Antifolate work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
What if the Antifolate compound I need is not listed?
Search by CAS number or SMILES first, since analogs of Antifolate compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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