Recombinant Cubilin Antibody - Primary antibody, specific to CUBN, Rabbit IgG

Cat. No.: Ab098153

GRADE & PURITY Recombinant, Validated, ExactAb™, See COA

Application

IHC, WB

Host species

Rabbit

Reactive species

Human

Isotype

Rabbit IgG

Conjugation

Unconjugated

Descripción general

Rabbit anti Human Cubilin Antibody, Recombinant, could be used for WB, IHC and so on.

Application:

WB: 1/500-1/2000

IHC: 1/50-1/200

Protein Function

Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.

Specifications

Product Name

Recombinant Cubilin Antibody - Primary antibody, specific to CUBN, Rabbit IgG

Sinónimos

cubilin (intrinsic factor-cobalamin receptor) | cubilin | CUBN | Cubulin | gp280 | IFCR | MGA1 | 460 kDa receptor antibody | cubilin (intrinsic factor-cobalamin receptor) antibody | Cubilin antibody | Cubilin precursor antibody | Cubn antibody | CUBN_HUMA

Especificaciones y pureza

Recombinant, ExactAb™, Validated, See COA

Especies hospedadoras

Rabbit

Especificidad

CUBN

Inmunógeno

A synthetic peptide derived from human Cubilin (AA 3350-3530)

Control positivo

WB: Human fetal kidney lysate. IHC: Human kidney tissue

Conjugación

Unconjugated

Grado

ExactAb™, Recombinant, Validated

Isotipo

Rabbit IgG

Tipo de cadena ligera

kappa

SDS-PAGE

150 kDa

Método de purificación

Protein A purified

Concentración

See COA

Almacenamiento y envío

Forma

Liquid

Condiciones de almacenamiento de almacenamiento

Store at -20°C,Avoid repeated freezing and thawing

Enviado en

Ice chest + Ice pads

Estabilidad y almacenamiento

Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imágenes

Western Blot: Recombinant Cubilin Antibody (Ab098153)

Recombinant Cubilin Antibody (Ab098153) - Western Blot
Western blot analysis of Recombinant Cubilin Antibody (Ab098153) expression in Human fetal kidney lysate.

IHC: Recombinant Cubilin Antibody (Ab098153)

Recombinant Cubilin Antibody (Ab098153) - IHC
Immunohistochemical analysis of HSF1 staining in human breast carcinoma formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with Recombinant Cubilin Antibody (Ab098153) at room temperature and detected using an HRP conjugated compact polymer system.

Aplicación

• Aplicación: Dilution info
• IHC:

  1/50-1/200;

• WB:

  1/500-1/2000 ;

Objetivos asociados (humanos)

CUBN Tbio Cubilin (0 Activities)

Discover Target: CUBN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)