Recombinant ERBB2/HER2 Antibody - Primary antibody, specific to ERBB2/HER2/CD340, Antibody of erb-b2 receptor tyrosine kinase 2, Antibody of erb-b2 receptor tyrosine kinase 2

CAS: 180288-69-1 Cat. No.: Ab304367 Peso molecular: 145531.50 Número EC: 695-702-2
Disponible para pedir
GRADE & PURITY Animal Free ? Animal-free — produced without animal-derived components to reduce contamination risk. Use in biomanufacturing and culture avoiding animal-origin material. Carrier Free ? Carrier-free — supplied without added carrier protein/stabilizer. Use when carriers (e.g. BSA) would interfere with conjugation or sensitive assays. Recombinant ? Recombinant — produced via recombinant expression for defined sequence and consistency. Use for reproducible, animal-free proteins of known origin. Validated ? Validated grade — performance confirmed in defined applications before release. Use when you want documented assurance the reagent works as stated. ExactAb™ ? ExactAb™ — Aladdin's antibody line emphasizing precision and validated quality. Use for reliable, specificity-validated antibody applications. Low Endotoxin ? Low-endotoxin grade — endotoxin reduced to low controlled levels. Use in sensitive biological work where high endotoxin would interfere. Azide Free ? Azide-free — without sodium azide preservative. Use in conjugations, cell work, or assays where azide is toxic or inhibitory. PBS Only ? PBS-only formulation — supplied in phosphate-buffered saline with no other additives. Use when you need a clean PBS buffer free of stabilizers/carriers. ≥95%(SDS-PAGE&SEC-HPLC) See COA
Application
Animal Model, ELISA, Flow Cytometry, Functional Assay
Host species
Human
Reactive species
Human, Mouse
Isotype
Human IgG1
Conjugation
Unconjugated
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
100μg
Ab304367-100μg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
42,90US$
Enter a quantity for the sizes you want to add.
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Why this grade

Animal Free,Carrier Free,Recombinant,ExactAb™,Low Endotoxin,Azide Free,Validated,PBS Only,≥95%(SDS-PAGE&SEC-HPLC),See COA Animal Free,Azide Free,Carrier Free,ExactAb™,Low Endotoxin,PBS Only,Recombinant,Validated for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C,Avoid repeated freezing and thawing Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Trastuzumab (anti-HER2) is a humanized IgG1 monoclonal antibody that selectively binds to HER2 with high affinity. Trastuzumab (anti-HER2) has the potential for HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer research.

Specifications

Product Name
Recombinant ERBB2/HER2 Antibody - Primary antibody, specific to ERBB2/HER2/CD340, Antibody of erb-b2 receptor tyrosine kinase 2
Sinónimos
Herceptin | Recombinant Trastuzumab Antibody | Anti-Human HER2, Humanized Antibody | Trastuzumab (Anti-Human HER2, Humanized Antibody) | Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody | Cerb
Especificaciones y pureza
Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, PBS Only, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Mecanismos bioquímicos y fisiológicos
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a
Especies hospedadoras
Human
Especificidad
ERBB2/HER2/CD340
Conjugación
Unconjugated
Grado
Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, PBS Only, Recombinant, Validated
Tipo de acción
INHIBITOR
Mecanismo de acción
Antibody of erb-b2 receptor tyrosine kinase 2
Tipo de cadena ligera
kappa
SDS-PAGE
26.0 kDa (Light Chain) & 50.6 kDa (Heavy Chain), under reducing conditions; 188.5 kDa, under non-reducing conditions.
Método de purificación
Protein A purified
Concentración
See COA
CAS
180288-69-1
Almacenamiento y envío
Forma
Liquid
Condiciones de almacenamiento de almacenamiento
Store at -80°C,Avoid repeated freezing and thawing
Enviado en
Dry ice packs + Cold packs
Estabilidad y almacenamiento
Store at 2-8℃ short term (1-2 weeks). Store at -80℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
Imágenes

Trastuzumab (anti-HER2) (T411999) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Trastuzumab (anti-HER2) (T411999). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Trastuzumab (anti-HER2) (T411999) - SEC
The purity of Trastuzumab (anti-HER2) (T411999) is more than 95% verified by HPLC.

Trastuzumab (anti-HER2) (T411999) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Trastuzumab (anti-HER2) (T411999) at 1.0 μg/mL for 1 hour at 4°C and detected with Alexa Fluor 488 - conjugated affinipure goat anti - Human IgG. Blue - Human IgG Isotype Control Antibody (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassNucleosides, nucleotides, and analogues
ClasePurine nucleosides
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentPurine nucleosides
Alternative Parents Glycosylamines  6-oxopurines  Pentoses  Hypoxanthines  Pyrimidones  Aminopyrimidines and derivatives  Aminoimidazoles  N-substituted imidazoles  Vinylogous amides  Tetrahydrofurans  Heteroaromatic compounds  Secondary alcohols  Oxacyclic compounds  Azacyclic compounds  Hydrocarbon derivatives  Organic oxides  Organopnictogen compounds  Primary alcohols  Primary amines  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Purine nucleoside - Glycosyl compound - N-glycosyl compound - 6-oxopurine - Pentose monosaccharide - Hypoxanthine - Purinone - Imidazopyrimidine - Purine - Aminopyrimidine - Pyrimidone - Aminoimidazole - N-substituted imidazole - Monosaccharide - Pyrimidine - Azole - Tetrahydrofuran - Vinylogous amide - Imidazole - Heteroaromatic compound - Secondary alcohol - Oxacycle - Azacycle - Organoheterocyclic compound - Primary amine - Amine - Alcohol - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
DescripciónThis compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB2 Tclin Epidermal growth factor receptor and ErbB2 (HER1 and HER2) (186 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB2 Tclin Epidermal growth factor receptor (487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB2 Tclin FASN/HER2 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate TypeFechaArticulo
ZJ25F1230365Certificate of AnalysisDec 18, 2025 Ab304367
Preguntas frecuentes y artículos
Citations of This Product
Referencias
1. Li Jinbo, Yu Jiang, Song Jia, Zhang Yingxi, Li Ning, Wang Zhaomeng, Qin Meng, Zhao Mingming, Zhang Baoyue, Huang Ruiping, Zhou Shuang, Liu Yubo, He Zhonggui, Liu Hongzhuo, Dan Liu, Wang Yongjun.  (2025)  Galloylated liposomes enable targeted drug delivery by overcoming protein corona shielding.  Nature Communications,  16  (1): (1-15).  [PMID:40854890] [10.1038/s41467-025-63198-4]
2. Dongmei Li, Chaofan Weng, Chaoyi Chen, Kan Li, Qiang Lin, Yi Ruan, Yi Ruan, Jingjing Zhang, Shuqian Wang, Jia Yao, Jia Yao.  (2022)  Optical biosensor based on weak value amplification for the high sensitivity detection of Pertuzumab in combination with Trastuzumab binding to the extracellular domain of HER2.  OPTICS EXPRESS,  30  (20): (36839-36848).  [PMID:36258605] [10.1364/OE.472012]
Calculadoras de soluciones
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