≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
GPR52 antagonist-1 (Compound 43) is a GPR52 antagonist with an IC 50 of 0.63 μM. GPR52 antagonist-1 reduces mHTT (mutant huntingtin protein) levels by targeting GPR52 and promotes survival of mouse primary striatal neurons
In Vivo
GPR52 antagonist-1 (Compound 43) (5 mg/kg; i.p.; once a day for 4 weeks) reduces mHTT levels and rescues HD-related phenotypes in HdhQ140 mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC 50 : 0.63 μM (GPR52)
| Canonical Smiles | C1=CC=C(C=C1)CCC=CC(=O)C2=CC=CS2 |
|---|---|
| IUPAC Name | (E)-5-phenyl-1-thiophen-2-ylpent-2-en-1-one |
| InChIKey | XUIAIACHIPOOHR-BJMVGYQFSA-N |
| INCHI | 1S/C15H14OS/c16-14(15-11-6-12-17-15)10-5-4-9-13-7-2-1-3-8-13/h1-3,5-8,10-12H,4,9H2/b10-5+ |
| Isomeric SMILES | C1=CC=C(C=C1)CC/C=C/C(=O)C2=CC=CS2 |
| PubChem CID | 156588927 |
| Molecular Weight | 242.34 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Solubility | DMSO : 250 mg/mL (1031.61 mM; Need ultrasonic) |
|---|---|
| Molecular Weight | 242.300 g/mol |
| XLogP3 | 4.300 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 5 |
| Exact Mass | 242.077 Da |
| Monoisotopic Mass | 242.077 Da |
| Topological Polar Surface Area | 45.300 Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 266.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 1 |
| Covalently-Bonded Unit Count | 1 |
