Ponceau 2R , CAS No.3761-53-3

CAS: 3761-53-3 Cat. No.: P104989 Molecular Weight: 480.42 Beilstein Registry Number: 5709350 EC Number: 223-178-3

Synonyms

Acid Scarlet 2R For Lakes | Certicol Ponceau MXS | Disodium 1-(2,4-dimethylphenylazo)-2-hydroxynaphthalene-3,6-disulphonate | Pas kwasowy 2 RL | Ponceau 2R (Biological stain) | Ponceau Xylidine (Biological stain) | Hidacid Scarlet 2R | Java ponceau 2r | S

Storage

Desiccated,Room temperature

Shipped In

Normal

Overview

Ponceau Xylidine is a red powder which is easily soluble in water. It is used as a substitute for cochineal dye.

Colour Index Number 16150

Ponceau Xylidine has been used as part of the Goldner’s trichome stain to stain thin sections. It has also been used to prepare Fuchsin-Ponceau solution to stain an amyotrophic lateral sclerosis tissue-engineered skin model (ALS-TES).

A stain used in histology and in Masson’s trichrome stain.

Specifications

Synonyms

Acid Scarlet 2R For Lakes | Certicol Ponceau MXS | Disodium 1-(2, 4-dimethylphenylazo)-2-hydroxynaphthalene-3, 6-disulphonate | Pas kwasowy 2 RL | Ponceau 2R (Biological stain) | Ponceau Xylidine (Biological stain) | Hidacid Scarlet 2R | Java ponceau 2r | S

Storage

Desiccated, Room temperature

Shipped In

Normal

Names and Identifiers

• Pubchem Sid: 488192241
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488192241
• Canonical Smiles: CC1=CC(=C(C=C1)N=NC2=C3C=CC(=CC3=CC(=C2O)S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+]
• IUPAC Name: disodium;4-[(2,4-dimethylphenyl)diazenyl]-3-hydroxynaphthalene-2,7-disulfonate
• InChIKey: YJVBLROMQZEFPA-UHFFFAOYSA-L
• INCHI: 1S/C18H16N2O7S2.2Na/c1-10-3-6-15(11(2)7-10)19-20-17-14-5-4-13(28(22,23)24)8-12(14)9-16(18(17)21)29(25,26)27;;/h3-9,21H,1-2H3,(H,22,23,24)(H,25,26,27);;/q;2*+1/p-2
• Isomeric SMILES: CC1=CC(=C(C=C1)N=NC2=C3C=CC(=CC3=CC(=C2O)S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+]
• WGK Germany: 3
• RTECS: QJ6825000
• Molecular Weight: 480.42
• Beilstein: 5709350
• Reaxy-Rn: 5709350
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5709350&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Naphthalenes
      • Subclass Naphthalene sulfonic acids and derivatives
        • Level5 Naphthalene sulfonates
          • Level6 2-naphthalene sulfonates

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Naphthalenes
• Subclass: Naphthalene sulfonic acids and derivatives
• Intermediate Tree Nodes: Naphthalene sulfonates
• Direct Parent: 2-naphthalene sulfonates
• Alternative Parents: 2-naphthalene sulfonic acids and derivatives 1-sulfo,2-unsubstituted aromatic compounds m-Xylenes Phenoxides Sulfonyls Organosulfonic acids Azo compounds Propargyl-type 1,3-dipolar organic compounds Organopnictogen compounds Organooxygen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: 2-naphthalene sulfonic acid or derivatives - 2-naphthalene sulfonate - Arylsulfonic acid or derivatives - 1-sulfo,2-unsubstituted aromatic compound - M-xylene - Xylene - Phenoxide - Monocyclic benzene moiety - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Organosulfonic acid - Sulfonyl - Azo compound - Organic alkali metal salt - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic sodium salt - Hydrocarbon derivative - Organic oxide - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic salt - Organic nitrogen compound - Organic oxygen compound - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as 2-naphthalene sulfonates. These are organic aromatic compounds that contain a naphthalene moiety that carries a sulfonic acid group at the 2-position. Naphthalene is a bicyclic compound that is made up of two fused benzene ring.
• External Descriptors: organic sodium salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Solubility: Soluble in water.
• Molecular Weight: 480.400 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 2
• Exact Mass: 480.004 Da
• Monoisotopic Mass: 480.004 Da
• Topological Polar Surface Area: 176.000 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 791.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Ping Niu, Chunhui Li, Chunyan Kong, Ning Zhang, Bingwei Xin, Fang Wang, Aili Wang, Dunqing Wang, Chunxiao Jia, Jingcheng Hao.  (2023)  Catalytic performance of alkaline earth metals doped-Co3O4 for azo dye degradation by peroxymonosulfate activation.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2023.132030]

2. Hua Li, Cheng Taozhi, Liang Zhiyong, Wei Ting.  (2022)  Investigation of the mechanism of phytate-modified biochar-catalyzed persulfate degradation of Ponceau 2R.  Biochar,  4  (1): (1-13).  [PMID:] [10.1007/s42773-022-00136-3]

3. Zhen Wang, Yiping Wang, Marta Vivar, Manuel Fuentes, Li Zhu, Lianwei Qin.  (2014)  Photovoltaic and photocatalytic performance study of SOLWAT system for the degradation of Methylene Blue, Acid Red 26 and 4-Chlorophenol.  APPLIED ENERGY,      [PMID:] [10.1016/j.apenergy.2014.01.039]

4. Feng-Hua Xu, Xiao Sun, Jun Zhu, Ling-Yang Kong, Yuan Chang, Ning Li, Wen-Xiang Hui, Cong-Peng Zhang, Yi-Ming Cheng, Wen-Xin Han, Zhi-Min Tian, Yan-Ning Qiao, Dong-feng Chen, Lei Liu, Da-Yun Feng, Jing Han.  (2025)  Significance of the gut tract in the therapeutic mechanisms of polydopamine for acute cerebral infarction: neuro-immune interaction through the gut-brain axis.  Frontiers in Cellular and Infection Microbiology,      [PMID:40104260] [10.3389/fcimb.2024.1413018]

5. Yuanzhi Gao, Jiahong Ji, Xiaosong Zhang.  (2025)  A photovoltaic–thermoelectric water treatment system based on heterogeneous photocatalytic oxidation: A preliminary experimental study.  ENERGY CONVERSION AND MANAGEMENT,      [PMID:] [10.1016/j.enconman.2025.120316]

6. Jianlin Luo, Mingbo Wang, Lulu Qiu, Qingqing Huang, Xiaoting Liu, Linying Hao, Ting Ye, Wencong Shang, Kaizhuo Wang, Hui Wang, Yonglu Meng, Kai Xu, Can Li.  (2025)  Biocompatible Pickering Emulsions from Andrias davidianus Byproducts for Promoting Burn Wound Healing.  Biomaterials Research,      [PMID:40836952] [10.34133/bmr.0233]