10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Raf inhibitor 1 is a potent Raf kinase inhibitor with K i s of 1 nM, 1 nM, and 0.3 nM for B-Raf WT , B-Raf V600E , and C-Raf , respectively.
In Vitro
Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:B-Raf 1 nM (Ki) B-Raf V600E 1 nM (Ki) c-Raf 0.3 nM (Ki)
| Isomeric SMILES | CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6 |
|---|---|
| PubChem CID | 44223999 |
| Molecular Weight | 478.9 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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