2,4,7-Triamino-6-phenylpteridine - Moligand™, 10mM in DMSO , Amiloride-sensitive sodium channel, ENaC blocker, CAS No.396-01-0, Amiloride-sensitive sodium channel, ENaC blocker

CAS: 396-01-0 Cat. No.: T408932 Molecular Weight: 253.26 EC Number: 206-904-3 PubChem CID: 5546

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

SKF8542 | 2,4,7-Pteridinetriamine, 6-phenyl-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Triamterene Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.
In vitro

Triamterene inhibits the epithelial sodium channels on principal cells in the late distal convoluted tubule and collecting tubule, which are responsible for 1-2% of total sodium reabsorption. Triamterene can achieve a modest amount of diuresis by decreasing the osmotic gradient necessary for water reabsorption from lumen to interstitium. Triamterene also has a potassium-sparing effect. Normally, the process of potassium excretion is driven by the electrochemical gradient produced by sodium reabsorption. As sodium is reabsorbed, it leaves a negative potential in the lumen, while producing a positive potential in the principal cell. This potential promotes potassium excretion through apical potassium channels. By inhibiting sodium reabsorption, triamterene also inhibits potassium excretion.

In vivo

4\'-hydroxylation of triamterene in humans appears to be mediated exclusively by CYP1A2. Inhibition or induction of CYP1A2 will change the time course of both triamterene and its active phase-II metabolite.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

SKF8542 | 2, 4, 7-Pteridinetriamine, 6-phenyl-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Triamterene (SKF8542) blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner with IC50 of 4.5 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

BLOCKER, CHANNEL BLOCKER

Mechanism of action

Amiloride-sensitive sodium channel, ENaC blocker

Product Properties

• ALogP: 1

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N
• PubChem CID: 5546
• Molecular Weight: 253.26

Associated Targets(Human)

SCNN1A Tclin Amiloride-sensitive sodium channel subunit alpha (0 Activities)

Discover Target: SCNN1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCNN1G Tclin Amiloride-sensitive sodium channel subunit gamma (0 Activities)

Discover Target: SCNN1G

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SCNN1B Tclin Amiloride-sensitive sodium channel subunit beta (0 Activities)

Discover Target: SCNN1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): >300

References

1. Shuyi Huang, Manli Guo, Lei Tan, Jiean Tan, Jinyi Wu, Youwen Tang, Yong Liang.  (2018)  Click chemistry-based core–shell molecularly imprinted polymers for the determination of pyrimethamine in fish and plasma samples.  Analytical Methods,  10  (23): (2750-2755).  [PMID:] [10.1039/C8AY00876K]

2. Cheng-Bin Gong, Yu-Bo Wei, Lan-Tao Liu, An-Xun Zheng, Yue-Hong Yang, Cheuk-fai Chow, Qian Tang.  (2017)  Photoresponsive hollow molecularly imprinted polymer for trace triamterene in biological samples.  Materials Science & Engineering C-Materials for Biological Applications,      [PMID:28482565] [10.1016/j.msec.2017.03.135]