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· · COA & SDS available for every product · Same-day shipping on in-stock items Z-VAD(OH)-FMK (Caspase Inhibitor VI) - ≥97% , CAS No.161401-82-7
Synonyms
Z-Val-Ala-Asp fluoromethylketone | SCHEMBL17494194 | benzyloxycarbonyl-Val-Ala-Asp fluoromethylketone | N-benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone | N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone | N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl
Storage
Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade ≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Information
Z-VAD(OH)-FMK (Caspase Inhibitor VI) Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan- caspase inhibitor.
Targets
Caspase
In vitro
Z-VAD(OH)-FMK is the non-methylated form of Z-VAD-FMK, and useful in studies including recombinant, or purified enzymes.
Specifications Synonyms
Z-Val-Ala-Asp fluoromethylketone | SCHEMBL17494194 | benzyloxycarbonyl-Val-Ala-Asp fluoromethylketone | N-benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone | N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone | N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl
Specifications & Purity
≥97%
Biochemical and Physiological Mechanisms
Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
Storage
Protected from light, Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Properties ALogP 1.246 HBD Count 3 Rotatable Bond 13
Names and Identifiers Pubchem Sid 504763900 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504763900 Canonical Smiles CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)CF)NC(=O)OCC1=CC=CC=C1 IUPAC Name (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoic acid InChIKey SUUHZYLYARUNIA-YEWWUXTCSA-N INCHI 1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1 Isomeric SMILES C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1 PubChem CID 5497171 Molecular Weight 453.46
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Class Peptidomimetics Subclass Hybrid peptides Intermediate Tree Nodes Not available Direct Parent Hybrid peptides Alternative Parents Dipeptides Valine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Alanine and derivatives Beta amino acids and derivatives Benzyloxycarbonyls Gamma-keto acids and derivatives N-acyl amines Alpha-haloketones Carbamate esters Secondary carboxylic acid amides Organic carbonic acids and derivatives Monocarboxylic acids and derivatives Carboxylic acids Hydrocarbon derivatives Organic oxides Organofluorides Organonitrogen compounds Alkyl fluorides Organopnictogen compounds Molecular Framework Aromatic homomonocyclic compounds Substituents Hybrid peptide - Alpha-dipeptide - Valine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Beta amino acid or derivatives - Alanine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Benzyloxycarbonyl - Gamma-keto acid - Monocyclic benzene moiety - Fatty amide - Fatty acyl - Keto acid - N-acyl-amine - Benzenoid - Carbamic acid ester - Alpha-haloketone - Carbonic acid derivative - Secondary carboxylic acid amide - Ketone - Carboxamide group - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Carboxylic acid - Organic oxygen compound - Alkyl halide - Hydrocarbon derivative - Organic nitrogen compound - Carbonyl group - Organic oxide - Organopnictogen compound - Alkyl fluoride - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Aromatic homomonocyclic compound Description This compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 90 mg/mL (198.47 mM); Ethanol: 90 mg/mL (198.47 mM); Water: Insoluble; Sensitivity Light sensitive ；Moisture sensitive DMSO(mg / mL) Max Solubility 90 DMSO(mM) Max Solubility 198.4739558 Water(mg / mL) Max Solubility ＜1 Molecular Weight 453.500 g/mol XLogP3 1.600 Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 8 Rotatable Bond Count 13 Exact Mass 453.191 Da Monoisotopic Mass 453.191 Da Topological Polar Surface Area 151.000 Ų Heavy Atom Count 32 Formal Charge 0 Complexity 680.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 3 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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