10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 9 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Amlodipine Besylate Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
In vitro
Amlodipine besylate reduces the declines in p85aPI3K, phosphorylated Akt, phosphorylated GSK-3β, heat-shock transcription factor-1, and Bcl-2 induced by H(2) O(2) , as well as the increases in cyclooxygenase-2, cytosolic cytochrome c, cleaved caspase 9, and cleaved caspase 3 in neuronal cell. Amlodipine significantly reduces systolic blood pressure (SBP), aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. Amlodipine elicits an NO-mediated relaxation and a leftward shift in the concentration-relaxation curve to bradykinin in isolated, pre-contracted, endothelium-intact porcine coronary arteries. Amlodipine increases the generation of NO from native endothelial cells, as detected by electron spin resonance spectroscopy and stimulated an 8-fold increase in cyclic GMP levels in cultured endothelial cells. Amlodipine elicits the NO-mediated relaxation of rat aortic rings, which do not express the B2 receptor. Amlodipine time-dependently attenuates the phosphorylation of protein kinase C (PKC) in endothelial cells, with a time course similar to the changes in eNOS phosphorylation, and prevents the phorbol-12-myristate-13-acetate-induced activation of PKC.
In vivo
Amlodipine besylate significantly decreases average indirect systolic blood pressure measurements from 198 mmHg to 155 mmHg in the cats. Amlodipine besylate appears to be a safe and effective oral treatment for systemic hypertension in cats when used chronically once daily as a single agent.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O |
|---|---|
| WGK Germany | 3 |
| RTECS | US7967700 |
| Molecular Weight | 567.05 |
| Reaxy-Rn | 8378713 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8378713&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | 195-204°C |
|---|
| 1. Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo. (2023) Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, [PMID:] [10.1016/j.jfca.2023.105825] |
| 2. Chunyan Zhang, Yifeng Fan, Liangliang Cai, Xiaofei Ma. (2023) Evaluation of kasugamycin as a chiral selector in capillary electrophoresis. ANALYST, 148 (6): (1322-1329). [PMID:36853240] [10.1039/D2AN01949C] |
| 3. Wang Yiran, Shi Jihua, Dai Dapeng, Cai Jianping, Wang Shuanghu, Hong Yun, Zhou Shan, Zhao Fangling, Zhou Quan, Geng Peiwu, Zhou Yunfang, Xu Xue, Luo Qingfeng. (2022) Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo. Frontiers in Pharmacology, [PMID:36052128] [10.3389/fphar.2022.909168] |
| 4. Xueying Li, Xiaokun Li, Suxiang Feng. (2022) A Photoelectrochemical Sensor for Firstly the Detection of Amlodipine Besylate Based on an MnC4Pc Coated ZnO Composite Materials. ELECTROANALYSIS, 35 (1): (e202100703). [PMID:] [10.1002/elan.202100703] |
| 5. Liu Wei, Wang Ruya, Hu Fan, Wu Pinping, Huang Tao, Fizir Meriem, He Hua. (2018) Novel mixed hemimicelles based on nonionic surfactant–imidazolium ionic liquid and magnetic halloysite nanotubes as efficient approach for analytical determination. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (28): (7357-7371). [PMID:30294762] [10.1007/s00216-018-1348-4] |
| 6. Jing Chen, Bao Qiong Li, Min Li Xu, Xue Wang, Yu Hong Jing, Hong Lin Zhai. (2016) Krawtchouk image moment method for the simultaneous determination of three drugs in human plasma based on fluorescence three-dimensional spectra. TALANTA, [PMID:27769504] [10.1016/j.talanta.2016.08.019] |
| 7. Qiuyan Zhu, Xin Xu, Jinqiu Xu, Xiaofei Ma. (2024) Cyclodextrins-based deep eutectic supramolecules as chiral selectors for enhanced enantioseparation in capillary electrophoresis. JOURNAL OF CHROMATOGRAPHY A, [PMID:39706136] [10.1016/j.chroma.2024.465599] |
| 8. Yalai Cen, Yuelan Fang, Xiaokun Li. (2025) NiCo2O4@g-C3N4 heterojunction for the construction of electrochemical sensor for the detection of amlodipine besylate. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.114712] |
| 9. Xiaofei Ma, Bohua Chen, Liangliang Cai. (2022) Investigation on improvement of enantioseparation in capillary electrophoresis based on maltodextrin by chiral ionic liquids. JOURNAL OF SEPARATION SCIENCE, 45 (18): (3604-3613). [PMID:35916273] [10.1002/jssc.202200408] |
