C-176 (STING inhibitor) - 10mM in DMSO , CAS No.314054-00-7

CAS: 314054-00-7 Cat. No.: C408221 Molecular Weight: 358.09 EC Number: 960-133-3

GRADE & PURITY 10mM in DMSO

Synonyms

2-​Furancarboxamide, N-​(4-​iodophenyl)​-​5-​nitro-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

C-176 (STING inhibitor) STING inhibitor C-176 is a potent, small-molecule inhibitor of STING , a central signaling component of the intracellular DNA sensing pathway.
In vitro

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. It directly targets mouse STING (mmSTING) but not human STING (hsSTING).

In vivo

C-176 attenuates STING-associated autoinflammatory disease in mice.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Synonyms

2-​Furancarboxamide, N-​(4-​iodophenyl)​-​5-​nitro-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: C1=CC(=CC=C1NC(=O)C2=CC=C(O2)[N+](=O)[O-])I
• Molecular Weight: 358.09
• Reaxy-Rn: 10548659
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=10548659&ln=