Experiments on the preparation of emulsion-type liquid pharmaceuticals
Experiments on the preparation of emulsion-type liquid pharmaceuticals
Emulsion-type liquid pharmaceuticals, also known as emulsions, refers to the two immiscible liquids are mixed, one of which is dispersed in the liquid droplet state in another liquid in the formation of non-homogeneous dispersion system. Usually prepared in small quantities, can be ground in the bowl or shaken in the bottle, such as gum arabic as an emulsifier, often using dry glue method and wet glue method. Factory production of large quantities of emulsion homogenizer, high-speed mixer, colloid mill preparation.
Operation method
Dry glue method/wet glue method
Materials and Instruments
Cod liver oil emulsion Liquid paraffin emulsion Dust application Turpentine application Move 1. Preparation of cod liver oil emulsion For more product details, please visit Aladdin Scientific website.
Cod liver oil Gum arabic Astragalus gum Distilled water Liquid paraffin Calcium hydroxide Peanut oil Turpentine Camphor Soft soap Garlic juice Procalcitonin hydrochloride Castor oil
Slides, microscopes, test tubes, mortar and pestle, flasks.
[Prescription]
Cod liver oil 500 ml Gum Arabic (fine powder) 125 g Astragalus gum (fine powder) 7 g Distilled water to 1000 ml
[Method of Preparation]
(1) Dry method: according to the ratio of oil: water: gum (4:2:1), mix the oil and gum gently, add water at a time, and keep grinding in one direction until thick milky white colostrum is generated (with cracking sound), then add water to dilute and grind it to the full amount.
(2) wet method: gum and water first research into the gum paste and add the West Astragalus gum paste, and then add oil while grinding to the colostrum made. Then add water to dilute to the full amount, grinding, that is obtained.
[Note]
(1) dry method should choose to use a dry milk bowl, separate measure. Grinding can not be stopped. Nor can it change direction.
(2) emulsion preparation must first be made into colostrum before dilution with water.
(3) Choose a rough milk bowl, pestle and mortar with good contact with the bottom of the milk bowl.
(4) can be added flavor and preservatives.
2. the preparation of liquid paraffin milk
[Prescription].
Liquid paraffin 12 ml Gum Arabic 4 g Purified water Add to 30 ml
[Preparation method]
(1) dry glue method: add gum arabic in liquid paraffin wax in stages, add purified water 8 ml research until the crackling sound, that is, into the colostrum. Then add an appropriate amount of purified water research, a total of 30 ml made of emulsion, that is obtained.
(2) wet glue method: take 8 ml of purified water in a beaker, add 4 g of gum arabic powder to form a gum paste. Move the paste into the milk bowl, and then add 12 ml of liquid paraffin in stages, plus the side of the grinding to the formation of colostrum, and then add an appropriate amount of purified water and research, a total of 30 ml, that is, obtained.
[Note]
(1) dry glue method is referred to as dry method, applicable to emulsifier for fine powder; wet glue method is referred to as wet method, the emulsifier can be used is not fine powder, where the pre can be made into slurry (glue: water for 1:2) can be.
(2) the preparation of colostrum, dry method should be used to dry the milk bowl, the measure of oil should not be stained with water, the measure of water should not be stained with oil. Oil phase and gum powder (emulsifier) fully research, according to the liquid paraffin: gum: water for 3:1:2 ratio of a time to add water, quickly grinding along the same direction, until the formation of thick milky white colostrum, during which can not change the direction of the grinding, and should not be intermittent grinding.
(3) Wet paste (glue: water for 1:2) should be made in advance, standby.
(4) the preparation of O / W-type emulsion must be made in the colostrum, before dilution with water.
(5) milk bowl should be selected with the inner wall of the porcelain bowl more rough.
[Quality requirements]
The resulting emulsion should be milky white, mirror oil droplets should be fine and uniform.
[Note]
This product is O/W emulsion because it uses gum arabic as emulsifier.
3. Preparation of stonecrop dust dressing
[Prescription]
Calcium hydroxide solution 50 ml Peanut oil 50 ml
[Method]
Take two kinds of drugs in the milk bowl grinding, that is to obtain.
[Note]
(1) This product to newborn soap as an emulsifier, so get W / O type emulsion.
(2) Peanut oil can be replaced by other vegetable oils, which should be sterilized by dry heat sterilization method before use.
4. Preparation of turpentine dressing
[Prescription].
Turpentine oil 65 ml Camphor 5 g Soap 7.5 g Distilled water 100 ml
[Method]
Take the soft soap and camphor in the mantle grinding liquefaction, add turpentine in turn constantly grinding until uniform. Then this mixture is added to the flask that has 25 ml of water, each time after adding, that is, vigorously shaking, until the fine endowment of the milky white liquid.
[Note]
(1) soft soap for potassium soap as an emulsifier, so the formation of O / W-type emulsion.
(2) camphor and turpentine for the skin hair also medicine.
5. emulsion type identification
(1) staining method: the above two emulsions coated on a slide, plus oil-soluble Sudan red staining, observed under the microscope. Another water-soluble methylene blue staining, the same microscopic examination, to determine the type of emulsion. Record the experimental results in Table 5.
(2) Dilution method: Take two test tubes, add one drop of liquid paraffin emulsion and one drop of lime application respectively, add about 5 ml of water and shake or turn over several times. Observe whether it can be mixed well. And judge the type of emulsion according to the experimental results.
[Note]
Staining method used in the test and reagents, the amount should not be too much, in order to prevent contamination or corrosion of the microscope. Table 5 Identification results of emulsion types 
Emulsion type: cod liver oil emulsion is ____________ type, lime application is _____________ type.
6. Formulate the preparation of garlic emulsion and determine its type
[Prescription].
Garlic juice 20.0 ml Procaine hydrochloride 2.0 g Gum Arabic powder 5.0 g Castor oil 73.0 ml