Experiments on the preparation of suppositories
Experiments on the preparation of suppositories
Suppositories can be categorized into two types according to their action. One is localized in the lumen; the other is absorbed from the lumen into the bloodstream for systemic action. The preparation of suppositories and the role of play, are closely related to the matrix. Therefore, the selected matrix must meet the quality requirements in order to make qualified suppositories.
Operation method
Molding method (hot melt method)
Principle
Suppositories can be categorized into two types according to their action. One is localized in the lumen; the other is absorbed from the lumen into the bloodstream for systemic action. The preparation of suppositories and the role of play, are closely related to the matrix. Therefore, the selected matrix must meet the quality requirements in order to make qualified suppositories. Molding method (hot melt method) preparation of suppositories, suppository mold, before use should be washed, dry, and then a cotton swab dipped in a small amount of lubricant, coated in the suppository mold, injection mold should be slightly overflow mold hole, if it contains insoluble drugs should be injected with stirring, so as to avoid the drug deposited in the bottom of the mold hole, and then after the cold and then cut off the part of the overflow, so that the bottom of the suppository is flat; take out suppositories should be pushed out from the base, if there is any excess lubricant, can be sucked off with filter paper. When removing the suppository, it should be pushed out from the base, if there is excess lubricant, it can be sucked away by filter paper. The lubricant coated in the bolus mold, fatty substrate with soap spiritus, water-soluble substrate with liquid paraffin, sesame oil and so on. After the suppository is made, respectively, wrapped in pharmaceutical wrappers, placed in glass bottles or cartons, stored at 25 ℃ below.
Materials and Instruments
Anti-inflammatory Move I. Preparation of glycerol suppositories For more product details, please visit Aladdin Scientific website.
Glycerol Dry carbonate Stearic acid Distilled water Anti-inflammatory Glycerol Semi-synthetic coconut oil Chlorhexidine acetate Ethyl alcohol Polysorbate-80 Ice chips
Pessary molds Water baths Evaporating dishes Milk bowls
1. PrescriptionGlycerin: 80 gDried carbonate: 2 gStearic acid: 2 gDistilled water: 10 g
2. Method of preparationDried sodium carbonate dissolved in water, add glycerin mixed with a water bath heating, slowly add stearic acid fine powder, with the addition of stirring, to be bubbling boil stops, the solution is clear, poured into the lubricant coated bolus mold (slightly overflowing the mouth of the mold), cold, cut flat, remove the package that is obtained.
3. Notes
(1) For transparent appearance, the saponification must be complete (1-2 hours on the water bath) and the acid should not be stirred too quickly to avoid stirring into the air bubbles.
(2) The amount of alkali is more than 10-15% than the theoretical amount, the saponification is fast, and the finished product is soft and transparent.
(3) The water content should not be too much, otherwise the finished product is cloudy, there are also advocated not to add water.
(4) The bolting mold is preheated to about 80°, cooling is slower, and the hardness of the finished product is more suitable.
II. Preparation of anti-inflammatory pain suppositories
1. PrescriptionAnti-inflammatory pain: 2.5 gSemi-synthetic coconut oil: 84.0 g
2. Method of preparationSemi-synthetic coconut oil placed in the evaporating dish melted on a water bath, cold to about 500C in the milk bowl and research fine anti-inflammatory pain powder research, while hot, poured into the has been coated with lubricants in the plug mold, condensation and then cut out the flat that is obtained.
3. Notes
(1) When adding anti-inflammatory pain, if the temperature is too high, it will cause discoloration.
(2) Anti-inflammatory pain is suspended in the matrix, can be used to melt the matrix with liquid grinding evenly, and then mixed with the rest of the matrix according to the incremental method.
III. Chlorhexidine suppository preparation
1. Prescription
Chlorhexidine acetate: 0.1 gPolysorbate-80: 0.4 gIce tablet: 0.02gEthanol: 1.0mlGlycerol: 12.0gGelatin: 5.4gDistilled water: 40.0mlVaginal suppositories: 4 pcs
2. Method of preparationTake the prescribed amount of gelatin, place it in a weighed evaporating dish, add 40 ml of distilled water, soak it for about 30 minutes to make it swell and soften, then add glycerin and heat it in a water bath to dissolve the gelatin, continue to heat it so that the weight reaches 36-40 g until it is ready.
Chlorhexidine add polysorbate-80, and mix well, the ice tablets dissolved in ethanol, mixed with the liquid under the stirring and then added to the preparation of glycerin gelatin, stirring evenly while hot into the coated with lubricant vaginal pessary mold (a total of 4), cooled and chipped, removed from the package that is obtained.
3. Notes
(1) Pitai Acetate is mixed with polysorbate-80, otherwise it affects the content of the finished product.
(2) Dissolve ice chips in ethanol.
(3) The finished product shall be a pale yellow transparent vaginal suppository.
(4) Each piece contains 20 mg of chlorhexidine acetate.
(5) In the prescription, polysorbate-80 is a surfactant, which can make chlorhexidine acetate evenly dispersed in the glycerol gelatin matrix.
(6) Glycerin gelatin matrix, with elasticity, and at body temperature does not melt, but slowly dissolved in body fluids to release the drug, so the effect is slow and long-lasting.