MK6-83 - Moligand™, 98%以上(HPLC) , Activator of TRPML1;Activator of TRPML3, CAS No.1062271-24-2, Activator of TRPML1;Activator of TRPML3

CAS: 1062271-24-2 Cat. No.: M288781 分子式: C₁₆H₂₀N₂O₂S₂ 分子量: 336.47

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

AKOS025147398 | MK683 | MK6-83 | 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide | 2-Thiophenesulfonamide, 5-methyl-N-(2-(1-piperidinyl)phenyl)- | GTPL9783 | s6947 | NCGC00402264-04 | 5-Methyl-N-(2-(1-piperidinyl)phenyl)-2-thiophenesulfonamide

Storage

20℃で保存

Shipped In

アイスチェスト＋アイスパッド

Specifications

同義語

AKOS025147398 | MK683 | MK6-83 | 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide | 2-Thiophenesulfonamide, 5-methyl-N-(2-(1-piperidinyl)phenyl)- | GTPL9783 | s6947 | NCGC00402264-04 | 5-Methyl-N-(2-(1-piperidinyl)phenyl)-2-thiophenesulfonamide

仕様と純度

Moligand™, 98%以上(HPLC)

生化学的・生理学的メカニズム

TRPMLチャネル活性化剤（EC50= 110 nM）。F408ΔおよびF465L TRPML変異体も活性化する（EC50値はそれぞれ0.1および1.23μM）。ムコリピドーシスIV型（MLIV）変異線維芽細胞のリソソームにおけるエンドリソソーム輸送と亜鉛ホメオスタシスを回復させる。

保管条件

20℃で保存

入荷

アイスチェスト＋アイスパッド

等級

Moligand™

アクションタイプ

ACTIVATOR

作用メカニズム

Activator of TRPML1;Activator of TRPML3

純度

≥98%(HPLC)

名前と識別子

• パブケム・シド: 504768682
• パブケム・シド・ウル: https://pubchem.ncbi.nlm.nih.gov/substance/504768682
• カノニカル・スマイル: CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3
• IUPAC Name: 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide
• InChIKey: IRGYSXZCDAWOOC-UHFFFAOYSA-N
• INCHI: 1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
• 異性体SMILES: CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3
• 分子量: 336.47
• Reaxy-Rn: 41646062
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=41646062&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 分類 Piperidines
      • Subclass Phenylpiperidines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 分類: Piperidines
• Subclass: Phenylpiperidines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpiperidines
• Alternative Parents: Sulfanilides Dialkylarylamines Aniline and substituted anilines 2,5-disubstituted thiophenes Organosulfonamides Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenylpiperidine - Sulfanilide - Tertiary aliphatic/aromatic amine - Aniline or substituted anilines - Dialkylarylamine - 2,5-disubstituted thiophene - Monocyclic benzene moiety - Organosulfonic acid amide - Benzenoid - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Thiophene - Aminosulfonyl compound - Heteroaromatic compound - Tertiary amine - Azacycle - Organic nitrogen compound - Organic oxide - Amine - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Organosulfur compound - Organic oxygen compound - Aromatic heteromonocyclic compound
• 説明: This compound belongs to the class of organic compounds known as phenylpiperidines. These are compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

関連ターゲット（人間）

MCOLN1 Tchem Mucolipin-1 (2 Activities)

Discover Target: MCOLN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MCOLN3 Tchem Mucolipin-3 (0 Activities)

Discover Target: MCOLN3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

化学的性質と物理的性質

• 溶解度: Solvent:DMSO, Max Conc. mg/mL: 33.65, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 6.73, Max Conc. mM: 20
• 分子量: 336.500 g/mol
• XLogP3: 3.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 336.097 Da
• Monoisotopic Mass: 336.097 Da
• Topological Polar Surface Area: 86.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 457.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

よくある質問

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1062271-24-2, the molecular formula is C16H20N2O2S2, and the molecular weight is 336.47 g/mol. InChIKey IRGYSXZCDAWOOC-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.