Indole-3-carbinol - Moligand™, 10mM in DMSO , Agonist of Aryl hydrocarbon receptor, CAS No.700-06-1, Agonist of Aryl hydrocarbon receptor

CAS: 700-06-1 Cat. No.: I407888 Molecular Weight: 147.17 EC Number: 211-836-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

(1H-indol-3-yl)methanol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Indole-3-carbinol Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Synonyms

(1H-indol-3-yl)methanol

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of Aryl hydrocarbon receptor

Names and Identifiers

• Isomeric SMILES: C1=CC=C2C(=C1)C(=CN2)CO
• RTECS: NL9483000
• Alternate CAS: 123334-15-6
• Molecular Weight: 147.17
• Reaxy-Rn: 121323
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=121323&ln=

Associated Targets(Human)

AHR Tclin Aryl hydrocarbon receptor (1 Activities)

Discover Target: AHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 96-99°C

References

1. Wenxiu Zheng, Wenhao Wang, Desheng Fu, Tianyu Zhang, Zhengrui Liang, Ling Yan, Changhong Liu, Lei Zheng.  (2022)  Microwave bag cooking affects the quality, glucosinolates content and hydrolysate production of broccoli florets.  FOOD RESEARCH INTERNATIONAL,      [PMID:36738020] [10.1016/j.foodres.2022.112401]

2. Wenxiu Zheng, Lin Ren, Wenzhuo Hao, Lei Wang, Changhong Liu, Lei Zheng.  (2022)  Encapsulation of indole-3-carbinol in Pickering emulsions stabilized by OSA-modified high amylose corn starch: Preparation, characterization and storage stability properties.  FOOD CHEMISTRY,      [PMID:35381538] [10.1016/j.foodchem.2022.132846]

3. Jia Cheng Qian, Dan Liu, Li Ping Lin, Wen Jing Zhu, Ren Xiang Tan.  (2022)  Minor bioactive indoles from kimchi mirror the regioselectivity in indole-3-carbinol oligomerization.  FOOD CHEMISTRY,      [PMID:35245758] [10.1016/j.foodchem.2022.132571]

4. Wen Jing Zhu, Li Ping Lin, Dan Liu, Jia Cheng Qian, Bei Bei Zhou, Dan Dan Yuan, Ren Xiang Tan.  (2021)  Pharmacophore-inspired discovery of FLT3 inhibitor from kimchi.  FOOD CHEMISTRY,      [PMID:34062461] [10.1016/j.foodchem.2021.130139]

5. Luyao Yang, Shuangshuang Wang, Jing Jin, Jiahui Wang, Wenyue Chen, Yun Xue, Liang Sheng, Yongning Zhai, Weifeng Yao.  (2024)  Sucralose triggers insulin resistance leading to follicular dysplasia in mice.  REPRODUCTIVE TOXICOLOGY,      [PMID:38880404] [10.1016/j.reprotox.2024.108644]

6. Yi Zheng, Qing-qing Chen, Hai-xiang Guo, Yu-xin Zhang, Ling-ling Qiu, Bing-bing Wang, Song Yu, Jia-rui Gao, Zhe Zhang, Jia-bao Zhang, Guo-shi Liu, Bao Yuan.  (2026)  Melatonin Promotes the Synthesis and Secretion of Growth Hormone in the Adenohypophysis by Activating the cAMP/FOXO1 Pathway.  JOURNAL OF PINEAL RESEARCH,  78  (2): (e70139).  [PMID:41870323] [10.1111/jpi.70139]

7. Mengxi Xiang, Cheng Zhou, Chundong Yao, Jia Liu, Lin Wang, Zheng Wang.  (2026)  A Self-Assembled Irinotecan Nanomedicine Abrogates Steatohepatitis-Induced Liver Metastasis and Potentiates Antitumor Efficacy against Colorectal Cancer.  ACS Nano,      [PMID:] [10.1021/acsnano.6c00855]