1,4,7,10-Tetraazacyclododecane - 10mM in DMSO , CAS No.294-90-6

CAS: 294-90-6 Cat. No.: T423047 Molecular Weight: 172.27 Beilstein Registry Number: 606114 EC Number: 425-450-9
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GRADE & PURITY 10mM in DMSO
Synonyms
NSC 629374 | S4927 | T1874 | Cyclen, 97% | MLS000069489 | Q63390538 | 1,4,7,10 Tetrazacyclododecane | BP-21532 | NCGC00018128-01 | NCGC00018128-03 | AM20090388 | BCP9000563 | Cyclen | GS-0907 | 5-26-11-00023 (Beilstein Handbook Reference) | CHEBI:37391 |
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
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Price
Qty
1ml
T423047-1ml
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 20 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Cyclen is a macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well as other imaging) agents.
A macrocyclic aza analogue of the crown ether 12-crown-4

Specifications

Synonyms
NSC 629374 | S4927 | T1874 | Cyclen, 97% | MLS000069489 | Q63390538 | 1, 4, 7, 10 Tetrazacyclododecane | BP-21532 | NCGC00018128-01 | NCGC00018128-03 | AM20090388 | BCP9000563 | Cyclen | GS-0907 | 5-26-11-00023 (Beilstein Handbook Reference) | CHEBI:37391 |
Specifications & Purity
10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
Canonical SmilesC1CNCCNCCNCCN1
IUPAC Name1,4,7,10-tetrazacyclododecane
InChIKeyQBPPRVHXOZRESW-UHFFFAOYSA-N
INCHI1S/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2
Isomeric SMILES C1CNCCNCCNCCN1
WGK Germany 3
RTECS XA5253000
UN Number 3259
Packing Group II
Molecular Weight 172.27
Beilstein 606114
Reaxy-Rn 606114
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=606114&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic nitrogen compounds
ClassOrganonitrogen compounds
SubclassAmines
Intermediate Tree Nodes Secondary amines
Direct ParentDialkylamines
Alternative Parents Azacyclic compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAliphatic heteromonocyclic compounds
Substituents Azacycle - Organoheterocyclic compound - Secondary aliphatic amine - Organopnictogen compound - Hydrocarbon derivative - Aliphatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as dialkylamines. These are organic compounds containing a dialkylamine group, characterized by two alkyl groups bonded to the amino nitrogen.
External Descriptors azacycloalkane - saturated organic heteromonocyclic parent - crown amine
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
A498 (42825 Activities)
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ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DLD-1 (17511 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DMS-273 (14108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM12 (47707 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
M14 (47487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MOLT-4 (49676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-3 (48710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-5 (45555 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OVCAR-8 (47708 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-8226 (44974 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXF 393 (41971 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SF-295 (48000 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-5 (47095 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SN12C (47755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNB-19 (46794 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNB-78 (14240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TK-10 (45540 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-251 (51189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-257 (46019 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UACC-62 (47335 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UO-31 (46270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
XF498 (12972 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
786-0 (47912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EKVX (44102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H322M (45589 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCC 2998 (41480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOP-18 (11577 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IGROV-1 (47897 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM-20L2 (14967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LOX IMVI (44321 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HOP-62 (47048 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LXFL 529 (14112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
M19-MEL (15326 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Malme-3M (44254 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNB-75 (44215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H226 (44470 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H23 (49055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H522 (44358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Trypanosoma brucei (78846 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SensitivityMoisture sensitive
Melt Point(°C)110-113°C
Molecular Weight172.270 g/mol
XLogP3-2.400
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass172.169 Da
Monoisotopic Mass172.169 Da
Topological Polar Surface Area48.100 Ų
Heavy Atom Count12
Formal Charge0
Complexity65.099
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Li Zhang, Nanxi Di, Zhi Wang, Song Zhao.  (2023)  Novel positively-charged polyamine nanofiltration membrane prepared by oligomer triggered interfacial polymerization for molecular separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2023.122129]
2. Zhiyu Jin, Xiuyang Zou, Guodong Xu, Zhe Sun, Feng Yan.  (2023)  Semi-Interpenetrating Network Anion Exchange Membranes by Thiol–Ene Coupling Reaction for Alkaline Fuel Cells and Water Electrolyzers.  MOLECULES,  28  (14): (5470).  [PMID:37513341] [10.3390/molecules28145470]
3. Yu-Ying Li, Feifan Guo, Jin Yang, Jian-Fang Ma.  (2023)  Efficient detection of metronidazole by a glassy carbon electrode modified with a composite of a cyclotriveratrylene-based metal–organic framework and multi-walled carbon nanotubes.  FOOD CHEMISTRY,      [PMID:37285624] [10.1016/j.foodchem.2023.136482]
4. Tingyu Li, Xinzhu Zhang, Yu Zhang, Jixiao Wang, Zhi Wang, Song Zhao.  (2023)  Nanofiltration membrane comprising structural regulator Cyclen for efficient Li+/Mg2+ separation.  DESALINATION,      [PMID:] [10.1016/j.desal.2023.116575]
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6. Ming Wang, Mengxin Li, Zhongyi Ren, Zhaohui Fei, Yingfei Hou, Q. Jason Niu.  (2022)  Novel macrocyclic polyamines regulated nanofiltration membranes: Towards efficient micropollutants removal and molecular separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2022.121180]
7. Ying Chen, Zengqiu Yang, Sibu Wang, Qin Ma, Lingyan Li, Xingjie Wu, Qianqian Guo, Ling Tao, Xiangchun Shen.  (2022)  Boosting ROS-Mediated Lysosomal Membrane Permeabilization for Cancer Ferroptosis Therapy.  Advanced Healthcare Materials,  12  (6): (2202150).  [PMID:36408929] [10.1002/adhm.202202150]
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11. Bo Song, Qi Liu, Hua Ma, Zhixin Tang, Chaolong Liu, Jinhua Zou, Mingqian Tan, Jingli Yuan.  (2020)  Tumor-targetable magnetoluminescent silica nanoparticles for bimodal time-gated luminescence/magnetic resonance imaging of cancer cells in vitro and in vivo.  TALANTA,      [PMID:32928404] [10.1016/j.talanta.2020.121378]
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15. Su Yafei, Peng Huawen, Liu Xufei, Li Jiapeng, Zhao Qiang.  (2024)  High performance, pH-resistant membranes for efficient lithium recovery from spent batteries.  Nature Communications,  15  (1): (1-9).  [PMID:39604329] [10.1038/s41467-024-54503-8]
16. Qiang Dong, Enlin Wang, Shaoxiao Liu, Wenze Wu, Baowei Su.  (2024)  Hollow fiber thin-film composite membrane regulated by macrocyclic polyamine molecules for high performance organic solvent nanofiltration.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2024.123036]
17. Ning Gan, Yuqing Lin, Baolong Wu, Yulong Qiu, Haopan Sun, Jingwen Su, Jianguo Yu, Qian Lin, Hideto Matsuyama.  (2024)  Supramolecular-coordinated nanofiltration membranes with quaternary-ammonium Cyclen for efficient lithium extraction from high magnesium/lithium ratio brine.  WATER RESEARCH,      [PMID:39492143] [10.1016/j.watres.2024.122703]
18. Junjie Wu, Keke Chai, Ying Tu, Kang Fang, Shuo Shi, Xiaochun Hu, Jihong Liu, Tianming Yao.  (2025)  Multifunctional Molecular Agent for Tau-targeted Combinational Therapy of Alzheimer’s Disease.  JOURNAL OF BIOLOGICAL CHEMISTRY,      [PMID:40812427] [10.1016/j.jbc.2025.110583]
19. Mu Ding, Lang Chen, Yuwei Xu, Bo Chen, Jie Ding, Rulei Wu, Chao Huang, Yi He, Yongdong Jin, Chuanqin Xia.  (2019)  Efficient capture of Tc/Re(VII, IV) by a viologen-based organic polymer containing tetraaza macrocycles.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2019.122581]
20. Qingqing Sun, Mengyuan Wang, Qingqing Wen, Haili Dong, Yanchao Lyu, Jie Han, Rong Guo.  (2025)  Hydrolytic degradation of nerve agent simulants accelerated by host-guest gold nanozymes.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.163290]
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