L-Isoleucine - Moligand™, ≥99% , CAS No.73-32-5

CAS: 73-32-5 Cat. No.: I103488 Molecular Weight: 131.18 Beilstein Registry Number: 4454 EC Number: 200-798-2

GRADE & PURITY Moligand™, ≥99%

Synonyms

alpha-Amino-beta-methylvaleric acid | erythro-L-Isoleucine | H-Ile-OH | 2-Amino-3-methylvaleric acid | (2S,3S)-2-Amino-3-methylpentanoic acid | (S)-Isoleucine | 2S,3S-Isoleucine | ISOLEUCINE, L- | L-(+)-Isoleucine | Isoleucine | L-Ile | l-isoleucine | (S,

Storage

Room temperature,Desiccated,Cool

Shipped In

Normal

Specifications

Synonyms

alpha-Amino-beta-methylvaleric acid | erythro-L-Isoleucine | H-Ile-OH | 2-Amino-3-methylvaleric acid | (2S, 3S)-2-Amino-3-methylpentanoic acid | (S)-Isoleucine | 2S, 3S-Isoleucine | ISOLEUCINE, L- | L-(+)-Isoleucine | Isoleucine | L-Ile | l-isoleucine | (S,

Specifications & Purity

Moligand™, ≥99%

Biochemical and Physiological Mechanisms

L-Isoleucine is an isomer of L-leucine and is an essential amino acid. It is synthesized from threonine and is a branched-chain hydrophobic amino acid.

Storage

Room temperature, Desiccated, Cool

Shipped In

Normal

Grade

Moligand™

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 488180047
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488180047
• Canonical Smiles: CC[C@H](C)[C@@H](C(=O)O)N
• IUPAC Name: (2S,3S)-2-amino-3-methylpentanoic acid
• InChIKey: AGPKZVBTJJNPAG-WHFBIAKZSA-N
• INCHI: 1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1
• Isomeric SMILES: CC[C@H](C)[C@@H](C(=O)O)N
• RTECS: NR4705000
• Molecular Weight: 131.18
• Beilstein: 4454
• Reaxy-Rn: 1721790
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1721790&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Isoleucine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Isoleucine and derivatives
• Alternative Parents: L-alpha-amino acids Methyl-branched fatty acids Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Isoleucine or derivatives - Alpha-amino acid - L-alpha-amino acid - Branched fatty acid - Methyl-branched fatty acid - Fatty acid - Fatty acyl - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic oxide - Organopnictogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as isoleucine and derivatives. These are compounds containing isoleucine or a derivative thereof resulting from reaction of isoleucine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Amino fatty acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SLC7A5 Tchem L-type amino acid transporter 1 (388 Activities)

Discover Target: SLC7A5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC36A1 Tchem Proton-coupled amino acid transporter 1 (102 Activities)

Discover Target: SLC36A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)

Discover Target: Pkm

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc16a10 Monocarboxylate transporter 10 (73 Activities)

Discover Target: Slc16a10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water. Slightly soluble in hot alcohol and hot acetic acid. Insoluble in ether.
• Specific Rotation[α]: 40.5 ° (C=4, 6mol/L HCl)
• Melt Point(°C): 288 °C
• Molecular Weight: 131.170 g/mol
• XLogP3: -1.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 131.095 Da
• Monoisotopic Mass: 131.095 Da
• Topological Polar Surface Area: 63.300 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 103.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Zhiyang Xu, Yinzhou Yan, Xingyuan Wang, Xiaolei Wang, Zhixiang Zhou, Xi Yang, Tianrui Zhai.  (2023)  Determination of Enantiomeric Excess by Optofluidic Microlaser near Exceptional Point.  Advanced Science,      [PMID:38072636] [10.1002/advs.202308362]

2. Zhen Lin, Chuangui Cai, Wei Chen, Qian Deng, Jialin Yang, Kaiyuan Huang, Haohua Deng, Xinhua Lin, Wei Chen, Wensong Yao.  (2023)  Micelle-mediated chemiluminescence of 6-aza-2-thiothymine-protected gold nanoclusters for carbazochrome sodium sulfonate detection.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:38086230] [10.1016/j.saa.2023.123738]

3. Wei Jia, Jiying Zhu.  (2023)  Molecular Mechanism of ε-Polylysine Treatment of Animal-Derived Foods: Glycine Amidinotransferase Activity Implicates Upregulation of l-Arginine and Creatine.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:37793042] [10.1021/acs.jafc.3c04033]

4. Jierui Yang, Benqi Chen, Huiting Qiu, Shuang Meng, Yunhui Yang.  (2023)  Ni3V2O8 nanoflower mimetic enzyme constructs a dual-signal system for ascorbic acid detection.  RSC Advances,  13  (37): (26102-26110).  [PMID:37664210] [10.1039/D3RA04202B]

5. Wenjing Wang, Yumin He, Lei Deng, Hui Wang, Xiaoying Liu, Qing-wen Gui, Zhong Cao, Zemeng Feng, Benhai Xiong, Yulong Yin.  (2023)  Peptide aptamer-based polyaniline-modified amperometric biosensor for L-lysine detection in real serum samples.  MEASUREMENT,      [PMID:] [10.1016/j.measurement.2023.113468]

6. Wei Jia, Xin Wang.  (2023)  3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner.  FOOD CHEMISTRY,      [PMID:37385056] [10.1016/j.foodchem.2023.136729]

7. Yichen Wang, Renjin Zheng, Pingping Wu, Youjia Wu, Lingyi Huang, Liying Huang.  (2023)  Determination of Multiple Neurotransmitters through LC-MS/MS to Confirm the Therapeutic Effects of Althaea rosea Flower on TTX-Intoxicated Rats.  MOLECULES,  28  (10): (4158).  [PMID:37241898] [10.3390/molecules28104158]

8. Chonghui Wei, Xuan Xie, Yue Mou, Shiqi Cheng, Jin Yang, Kaixin Xue, Kewei Yu, Xinru Lin, Chunfen Zhang, Yujie Zhao, Xingyu Luo, Yilin Wang.  (2023)  Controllable synthesis of MoS2@TiO2 nanocomposites for visual detection of dopamine secretion with highly-efficient enzymatic activity.  ANALYST,  148  (8): (1732-1742).  [PMID:36938870] [10.1039/D3AN00089C]

9. Yankui Xing, Zhengda Zhou, Fangfang Li, Shuangping Tian, Yuxi Liang, Sixian Li, Yanan Zhou, Yun Gao.  (2023)  Solid-liquid equilibrium and dissolution thermodynamic properties of L-isoleucine in binary solvent mixtures.  JOURNAL OF CHEMICAL THERMODYNAMICS,      [PMID:] [10.1016/j.jct.2023.107035]

10. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou.  (2023)  Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36736046] [10.1016/j.saa.2023.122380]

11. Zhang Jing, Yang Junqing, Luo Ying, Li Jiansha, Gong Tao, Huang Suqiong, Xiong Yan, Jiang Xinhui.  (2022)  Determination of 23 Amino Acids and Amines in Plasma and Cortex of C57BL/6 Mice with HPLC–FLD.  JOURNAL OF CHROMATOGRAPHIC SCIENCE,      [PMID:36572394] [10.1093/chromsci/bmac103]

12. Fangning Liu, Zhe Li, Ge Kang, Zhai Liu, Shicheng Zhu, Ruxue He, Chenghui Zhang, Chuanxia Chen, Yizhong Lu.  (2022)  Ratiometric sensing of α-glucosidase and its inhibitor based on MnO2 nanosheets promoted in-situ fluorescent reactions.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2022.108352]

13. Yujiao Tu, Ze Liu, Lei Jiang, Yingying Xiang, Fei Song, Lifen Meng, Xiuling Ji, Lin Yuan.  (2022)  Green ratiometric fluorescent dual-mode nanosensor for highly selective and sensitive detection of new coccine in food.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2022.111024]

14. Lei Di, Shengyu Cheng, Yan Zhu, Yueying Jin, Chao Qi, Lingli Zhang, Minghui Zhang, Xin Wang, Yu Han, Xi-Ling Li, Jun Zhe Min.  (2022)  Development of a diphenyl sulfide structure derivatization reagent for amino acid enantiomers analysis: Application of dynamic monitoring in human urine after drinking wine.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:36528900] [10.1016/j.chroma.2022.463698]

15. Lin Yuan, Lei Jiang, Ze Liu, Yingying Xiang, Fei Song, Yujiao Tu.  (2022)  Selective and sensitive simultaneous detection of tartrazine and Hg2+ based on N-doped yellow-green fluorescent carbon dots.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2022.110893]

16. Hui Yuan, Yu Chen, Ruikang Lin, Dan Tan, Jiaojiao Zhang, Yongmei Wang, Ehud Gazit, Wei Ji, Rusen Yang.  (2022)  Modified Stranski–Krastanov Growth of Amino Acid Arrays toward Piezoelectric Energy Harvesting.  ACS Applied Materials & Interfaces,      [PMID:36196653] [10.1021/acsami.2c13399]

17. Lei Jiang, Lin Yuan, Ze Liu, Yingying Xiang, Fei Song, Lifen Meng, Yujiao Tu.  (2022)  Facile hydrothermal synthesis and purification of fluorescent carbon dots for food colorant tartrazine detection based on a dual-mode nanosensor.  Analytical Methods,  14  (41): (4127-4132).  [PMID:36222124] [10.1039/D2AY01140A]

18. Hang Zhang, Jun Jiang Luo, Zhe Sun, Hao Lin Zou, Hong Qun Luo, Nian Bing Li, Bang Lin Li.  (2022)  Hydrogels allow the precise growth tracking of plasmonic gold nanoparticles for mercury analysis.  Journal of Materials Chemistry C,  10  (39): (14508-14516).  [PMID:] [10.1039/D2TC02483G]

19. Hai-Bin Qin, Jun-Ping Zhou, Bo Zhang, Zhi-Qiang Liu, Yu-Guo Zheng.  (2022)  Combing with redox regulation via quorum-sensing system and fermentation strategies for improving D-pantothenic acid production.  PROCESS BIOCHEMISTRY,      [PMID:] [10.1016/j.procbio.2022.08.012]

20. Yingying Xiang, Yujiao Tu, Lei Jiang, Lin Yuan, Ze Liu, Qiang Xie, Xuequan Xiong, Fei Song.  (2022)  Orange fluorescent dual-mode nanoprobe for selective and sensitive detection of amaranth based on S,N-Doped carbon dots.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2022.110533]

21. Wenjing Wang, Yumin He, Yunling Gao, Hongrui Gao, Lei Deng, Qingwen Gui, Zhong Cao, Yulong Yin, Zemeng Feng.  (2022)  A peptide aptamer based electrochemical amperometric sensor for sensitive L-glutamate detection.  BIOELECTROCHEMISTRY,      [PMID:35623273] [10.1016/j.bioelechem.2022.108165]

22. Shutong Yang, Liancheng Gu, Fangling Wu, Xinhua Dai, Fuxing Xu, Qiaoyu Li, Xiang Fang, Shaoning Yu, Chuan-Fan Ding.  (2022)  The chirality determination of amino acids by forming complexes with cyclodextrins and metal ions using ion mobility spectrometry, and a DFT calculation.  TALANTA,      [PMID:35272154] [10.1016/j.talanta.2022.123363]

23. Ling Li, Miaomiao Zhang, Ran Li, Huan Jiang, Zhongde Liu.  (2021)  Facile synthesis of highly luminescent rod-like terbium-based metal–organic frameworks for sensitive detection of olaquindox.  Analytical Methods,  13  (34): (3785-3791).  [PMID:34350907] [10.1039/D1AY00824B]

24. Bo Zhang, Li Chen, Jie-Yi Jin, Na Zhong, Xue Cai, Shu-Ping Zou, Hai-Yan Zhou, Zhi-Qiang Liu, Yu-Guo Zheng.  (2021)  Strengthening the (R)-pantoate pathway to produce D-pantothenic acid based on systematic metabolic analysis.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2021.101283]

25. Jing Zhang, Xinxin Wen, Yuting Li, Jing Zhang, Xian Li, Cheng Qian, Yonghui Tian, Rui Ling, Yixiang Duan.  (2021)  Diagnostic approach to thyroid cancer based on amino acid metabolomics in saliva by ultra-performance liquid chromatography with high resolution mass spectrometry.  TALANTA,      [PMID:34517597] [10.1016/j.talanta.2021.122729]

26. Lili Zhu, Jun Dong, Qunfeng Zeng, Mianran Chao, Kuiliang Gong, Weimin Li, Xiaobo Wang.  (2021)  A comprehensive study of amino acids based ionic liquids as green lubricants for various contacts.  TRIBOLOGY INTERNATIONAL,      [PMID:] [10.1016/j.triboint.2021.107137]

27. Pengpeng Zhang, Shuai Liu, Shuang Yang, Yuanhong Wang, Tingfu Jiang, Mingming Yu, Zhihua Lv.  (2021)  Simultaneous determination of chito-oligosaccharides in rat plasma by the LC-MS/MS method: application to a pharmacokinetic study.  Analytical Methods,  13  (29): (3242-3248).  [PMID:34184005] [10.1039/D1AY00772F]

28. Bochuan Yuan, Ziwei Wu, Wei Ji, Dong Liu, Xiang Guo, Donghui Yang, Aili Fan, Hongli Jia, Ming Ma, Wenhan Lin.  (2021)  Discovery of cyclohexadepsipeptides with anti-Zika virus activities and biosynthesis of the nonproteinogenic building block (3S)-methyl-l-proline.  JOURNAL OF BIOLOGICAL CHEMISTRY,  297  (1):   [PMID:34029593] [10.1016/j.jbc.2021.100822]

29. Lamei Yang, Feng Luo, Weili Wei.  (2021)  Simultaneous determination of the concentration and enantiomeric excess of amino acids with a coumarin-derived achiral probe.  Analytical Methods,  13  (16): (1905-1910).  [PMID:33913945] [10.1039/D1AY00271F]

30. Yuanyuan Zhang, Hedan Xu, Yuling Yang, Fengmei Zhu, Yunxun Pu, Xiaoshuang You, Xiaoling Liao.  (2021)  Efficient fluorescence resonance energy transfer-based ratiometric fluorescent probe for detection of dopamine using a dual-emission carbon dot-gold nanocluster nanohybrid.  JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,      [PMID:] [10.1016/j.jphotochem.2021.113195]

31. Xinying Wang, Ming Gao, Zihan Wang, Weiqi Cui, Jingxian Zhang, Weijie Zhang, Yu Xia, Bo Wei, Youcai Tang, Xia Xu.  (2021)  Hepatoprotective effects of oridonin against bisphenol A induced liver injury in rats via inhibiting the activity of xanthione oxidase.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:33515877] [10.1016/j.scitotenv.2021.145301]

32. Chengxiang Chu, Rui Huang, Xianfeng Wang, Yuanyi Deng, Tao Gu, Danqun Huo, Liang Zhang, Daidi Zhong, Changjun Hou.  (2021)  A Turn-on Fluorescent Sensor Based on Copper-Based Metal-Organic Frameworks for Sensitive Detection of L-Histidine.  NANO,      [PMID:] [10.1142/S1793292021500156]

33. Yumin He, Li Zhou, Lei Deng, Zemeng Feng, Zhong Cao, Yulong Yin.  (2020)  An electrochemical impedimetric sensing platform based on a peptide aptamer identified by high-throughput molecular docking for sensitive l-arginine detection.  BIOELECTROCHEMISTRY,      [PMID:32882443] [10.1016/j.bioelechem.2020.107634]

34. Yuanyuan Zhang, Mei Yang, Zeyu Shao, Hedan Xu, Yan Chen, Yuling Yang, Wenfeng Xu, Xiaoling Liao.  (2020)  A paper-based fluorescent test for determination and visualization of cysteine and glutathione by using gold-silver nanoclusters.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2020.105327]

35. Yujiao Tu, Xuemei Chen, Yingying Xiang, Xiaotian Yuan, Kunhao Qin, Yunlin Wei, Zhiwei Xu, Qi Zhang, Xiuling Ji.  (2020)  Hydrothermal Synthesis of a Novel Mesoporous Silica Fluorescence Carbon Dots and Application in Cr(VI) and Folic Acid Detection.  NANO,      [PMID:] [10.1142/S1793292020500903]

36. Lijuan Huang, Liyun Wang, Zhiyong Nie, Yongan Wang.  (2020)  Simultaneous quantitative measurements of Tl+ and Pb2+ in drinking water based on nanoplasmonic probe.  FOOD CHEMISTRY,      [PMID:32146290] [10.1016/j.foodchem.2020.126543]

37. Zhixiong Hu, Xin-Yue Jiao, Li Xu.  (2019)  The N,S co-doped carbon dots with excellent luminescent properties from green tea leaf residue and its sensing of gefitinib.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2019.104588]

38. Li Te, Xie Lianwu, Long Ruiqing, Tong Chaoying, Guo Ying, Tong Xia, Shi Shuyun, Lin Qinlu.  (2019)  Cetyltrimethyl ammonium mediated enhancement of the red emission of carbon dots and an advanced method for fluorometric determination of iron(III).  MICROCHIMICA ACTA,  186  (12): (1-8).  [PMID:31734753] [10.1007/s00604-019-3933-4]

39. Fei Qu, Qianqian Yang, Bingjie Wang, Jinmao You.  (2019)  Aggregation-induced emission of copper nanoclusters triggered by synergistic effect of dual metal ions and the application in the detection of H2O2 and related biomolecules.  TALANTA,      [PMID:31594584] [10.1016/j.talanta.2019.120289]

40. Xue-Mei Han, Yan-Jie Qin, Ying Zhu, Xin-Lin Zhang, Nan-Xi Wang, Ying Rang, Xue-Jia Zhai, Yong-Ning Lu.  (2019)  Development of an underivatized LC-MS/MS method for quantitation of 14 neurotransmitters in rat hippocampus, plasma and urine: Application to CUMS induced depression rats.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:31288191] [10.1016/j.jpba.2019.06.043]

41. Renjie Hui, Yueying Gao, Jingyi Liu, Haili Liu, Chunlei Tang, Bainian Feng.  (2018)  Determination of an isonicotinylhydrazide derivative, a novel positive inotropic compound, in mouse plasma by LC–MS/MS and its application to a pharmacokinetics study.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:30496986] [10.1016/j.jpba.2018.10.034]

42. Jie Yang, Zhongming Huang, Yalei Hu, Jia Ge, Jianjun Li, Zhaohui Li.  (2018)  A facile fluorescence assay for rapid and sensitive detection of uric acid based on carbon dots and MnO2 nanosheets.  NEW JOURNAL OF CHEMISTRY,  42  (18): (15121-15126).  [PMID:] [10.1039/C8NJ02607F]

43. Dan Huang, Qing-Song Jiang, Jun-Qing Yang, Ting Cui, Nian-Ru Wang, Ting-Ting Du, Xin-Hui Jiang.  (2018)  Simultaneous determination of nine analytes related to the pathogenesis of diabetic encephalopathy in diabetic rat cortex and hippocampus by HPLC-FLD.  BIOMEDICAL CHROMATOGRAPHY,  32  (11): (e4338).  [PMID:30003560] [10.1002/bmc.4338]

44. Xinru Wang, Dezhen Wang, Zhiqiang Zhou, Wentao Zhu.  (2017)  Subacute oral toxicity assessment of benalaxyl in mice based on metabolomics methods.  CHEMOSPHERE,      [PMID:29054078] [10.1016/j.chemosphere.2017.10.085]

45. Xu Hui-Huang, Deng Hao-Hua, Lin Xiao-Qing, Wu Yan-Yu, Lin Xiu-Ling, Peng Hua-Ping, Liu Ai-Lin, Xia Xing-Hua, Chen Wei.  (2017)  Colorimetric glutathione assay based on the peroxidase-like activity of a nanocomposite consisting of platinum nanoparticles and graphene oxide.  MICROCHIMICA ACTA,  184  (10): (3945-3951).  [PMID:] [10.1007/s00604-017-2429-3]

46. Fuchen Zhang, Qiuxia Wang, Lipeng Wang, Yongping Bai.  (2017)  Implementing plant-derived isosorbide and isomannide as comonomers for polyester synthesis: Effects of crystallization properties on optical properties.  JOURNAL OF APPLIED POLYMER SCIENCE,  134  (43): (45444).  [PMID:] [10.1002/app.45444]

47. Zhijiao Tang, Zhenhua Lin, Gongke Li, Yuling Hu.  (2017)  Amino Nitrogen Quantum Dots-Based Nanoprobe for Fluorescence Detection and Imaging of Cysteine in Biological Samples.  ANALYTICAL CHEMISTRY,      [PMID:28266840] [10.1021/acs.analchem.7b00284]

48. Jing Liu, Lingjie Meng, Zhaofu Fei, Paul J. Dyson, Xunan Jing, Xing Liu.  (2016)  MnO2 nanosheets as an artificial enzyme to mimic oxidase for rapid and sensitive detection of glutathione.  BIOSENSORS & BIOELECTRONICS,      [PMID:27886603] [10.1016/j.bios.2016.11.046]

49. Zuguang Shen, Guocheng Han, Chuanfu Liu, Xiaoying Wang, Runcang Sun.  (2016)  Green synthesis of silver nanoparticles with bagasse for colorimetric detection of cysteine in serum samples.  JOURNAL OF ALLOYS AND COMPOUNDS,      [PMID:] [10.1016/j.jallcom.2016.05.348]

50. Xiangyu Jiang, Fenghua Geng, Yongxiang Wang, Jinhua Liu, Peng Qu, Maotian Xu.  (2016)  Fluorescence turn-on and colorimetric dual readout assay of glutathione over cysteine based on the fluorescence inner-filter effect of oxidized TMB on TMPyP.  BIOSENSORS & BIOELECTRONICS,      [PMID:26971272] [10.1016/j.bios.2016.02.068]

51. Xialin Chen, Yujie Guo, Yuanjia Hu, Boyang Yu, Jin Qi.  (2016)  Quantitative analysis of highly similar salvianolic acids with 1H qNMR for quality control of traditional Chinese medicinal preparation Salvianolate Lyophilized Injection.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:26970983] [10.1016/j.jpba.2016.02.016]

52. Wang Dezhen, Zhang Ping, Wang Xinru, Wang Yao, Zhou Zhiqiang, Zhu Wentao.  (2016)  NMR- and LC–MS/MS-based urine metabolomic investigation of the subacute effects of hexabromocyclododecane in mice.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  23  (9): (8500-8507).  [PMID:26786581] [10.1007/s11356-015-5940-2]

53. Su Guo, Fang Zhang, Haoyang Wang, Manyu Zhang, Zhixu Zhang, Xiang Zhang, Yinlong Guo.  (2015)  Behaviors of Leucine and Isoleucine in Ion Mobility-Quadrupole Time of Flight Mass Spectrometry.  CHINESE JOURNAL OF CHEMISTRY,  33  (12): (1359-1364).  [PMID:] [10.1002/cjoc.201500670]

54. Yehao Ma, Pingjie Huang, Dibo Hou, Jinhui Cai, Qiang Wang, Guangxin Zhang.  (2015)  The spectral resolution of unknown mixture based on THz spectroscopy with self-modeling technique.  CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS,      [PMID:] [10.1016/j.chemolab.2015.10.017]

55. Sihua Guo, Fangyuan Zheng, Fang Zeng, Shuizhu Wu.  (2015)  A fluorescent probe capable of discriminately and simultaneously detecting dl-dithiothreitol and single sulfhydryl-containing thiols.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2015.10.036]

56. Hongyu Zhang, Bin Lu, Xuelin You, Fengyu Ma, Jingxiang Zhao, Qinghai Cai.  (2015)  Mixed Oxides FeVOx for Selective Oxidation of Octanol to Octanal under Solvent-free Condition.  JOURNAL OF THE CHINESE CHEMICAL SOCIETY,  62  (8): (722-727).  [PMID:] [10.1002/jccs.201400167]

57. Yifan Zhang, Youwei Zhu, Na Zhao, Jinhui Wu, Yiqiao Hu.  (2015)  Application of isothermal titration calorimeter for screening bitterness-suppressing molecules of quinine.  FOOD CHEMISTRY,      [PMID:26213068] [10.1016/j.foodchem.2015.06.070]

58. Qi-Yong Cai, Jie Li, Jia Ge, Lin Zhang, Ya-Lei Hu, Zhao-Hui Li, Ling-Bo Qu.  (2015)  A rapid fluorescence “switch-on” assay for glutathione detection by using carbon dots–MnO2 nanocomposites.  BIOSENSORS & BIOELECTRONICS,      [PMID:25957074] [10.1016/j.bios.2015.04.077]

59. Qiuxiang Wu, Zhizhou Yang, Jinshui Yao, Donghong Yu.  (2015)  Synthesis and biodegradation studies of optically active poly(amide–imide)s based on N,N′-(pyromellitoyl)-bis-l-amino acid.  HIGH PERFORMANCE POLYMERS,      [PMID:] [10.1177/0954008315569251]

60. Yonglong Li, Zihou Li, Yuexia Gao, An Gong, Yujie Zhang, Narayan S. Hosmane, Zheyu Shen, Aiguo Wu.  (2014)  “Red-to-blue” colorimetric detection of cysteine via anti-etching of silver nanoprisms.  Nanoscale,  6  (18): (10631-10637).  [PMID:25083798] [10.1039/C4NR03309D]

61. Juan Lv, Li Zhang, Musammir Khan, Xiangkui Ren, Jintang Guo, Yakai Feng.  (2014)  Biodegradable depsipeptide–PDO–PEG-based block copolymer micelles as nanocarriers for controlled release of doxorubicin.  REACTIVE & FUNCTIONAL POLYMERS,      [PMID:] [10.1016/j.reactfunctpolym.2014.06.005]

62. En Zhang, Peng-Yan Bai, De-Yun Cui, Wen-Chao Chu, Yong-Gang Hua, Qin Liu, Hai-Yang Yin, Yong-Jie Zhang, Shangshang Qin, Hong-Min Liu.  (2017)  Synthesis and bioactivities study of new antibacterial peptide mimics: The dialkyl cationic amphiphiles.  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:29126736] [10.1016/j.ejmech.2017.10.044]

63. Qiao Tong, Weijie Shen, Lu Zhang, Yu Cao, Xi Zou, Tingting Shi, Rang Xiao Zhuang, Shourong Liu, Jianjun Xi.  (2025)  A “turn-on” fluorescence polyethyleneimine-based nanosensor chemosensor for sensing of l-lysine.  TALANTA,      [PMID:40184936] [10.1016/j.talanta.2025.128045]

64. Zhipeng Liu, Chunying Teng, Wenting Wan, Fan Wu, Chao Wu, Weiping Ji, Yujuan Shan.  (2024)  A panel of four plasma amino acids is a promising biomarker for newly diagnosed bladder cancer.  CLINICAL NUTRITION,      [PMID:38776618] [10.1016/j.clnu.2024.05.003]

65. Wen Zang, Minjie Peng, Yiyu Yang, Chenguang Zhang, Zhusheng Liu, Le Wang, Chaozhen Wang, Jie Lin, Tianxiang Chen, Yujie Zhang, Juan Li, Aiguo Wu.  (2024)  Colorimetric detection of neomycin sulfate in serum based on ultra-small gold nanoparticles with peroxidase-like activity.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:38950479] [10.1016/j.saa.2024.124686]

66. Yamin Liu, Xunjiang Wang, Jiaojiao Wei, Kangning Fu, Yilin Chen, Linnan Li, Zhengtao Wang, Li Yang.  (2024)  Comprehensive Profiling of Amino Acids and Derivatives in Biological Samples: A Robust UHPLC-MS/MS Method for Investigating Acute Lung Injury.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:38537486] [10.1016/j.chroma.2024.464816]

67. Yao Huihui, Xu Jiancheng, Zhou Aina, Shen Danyang, Dong Qiuchen, Yang Xiaodong, Li Mengyu, Mi Xiuwei, Lu Yang, Zhong Runze, Shi Xinyu, Tai Qingliang, Chen Guoliang, Shi Bo, Sun Liang, Zhou Diyuan, Yao Yizhou, He Songbing.  (2024)  Gut microbiota-mediated hsa_circ_0126925 targets BCAA metabolic enzyme BCAT2 to exacerbate colorectal cancer progression.  MOLECULAR CANCER RESEARCH,      [PMID:39642324] [10.1158/1541-7786.MCR-24-0434]

68. Chunlei Tan, Lei Peng, Mingming Wang, Hongyu Mu, Feng Zhang, Si Huang, Kuan Wu, Jun Sheng, Yang Tian, Cunchao Zhao.  (2024)  High temperature steaming pretreatment improves quality and flavor of the walnut meal soy sauce.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2024.117249]

69. Zhao Jing-yi, Gao Fan, Wu Mengru, Li Yang, Chen Yong, Xiao Zijun.  (2025)  Microbial synthesis of enantiopure (S)-2-methylbutanoic acid via L-isoleucine catabolism in Bacillus spizizenii.  WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY,  41  (4): (1-15).  [PMID:40148725] [10.1007/s11274-025-04324-8]

70. Wenjing Wang, Yumin He, Suxiang He, Xiaoying Liu, Qing-wen Gui, Lei Deng, Hui Wang, Zhong Cao, Zemeng Feng, Benhai Xiong, Yulong Yin.  (2024)  Peptide aptamer-based colorimetric sensor for the detection of L-tryptophan in porcine serum.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.109896]

71. Wei Wei, Fengjian Chu, Guanru Chen, Shiwen Zhou, Cuirong Sun, Hongru Feng, Yuanjiang Pan.  (2024)  Prebiotic Formation of Peptides Through Bubbling and Arc Plasma.  CHEMISTRY-A EUROPEAN JOURNAL,      [PMID:38802327] [10.1002/chem.202401809]

72. Mingyue Chu, Ying Wang, Jianjiao Xin, Dawei Chu, Yikun Liu, Daozheng Song, Guixin Yang, Huiyuan Ma, Haijun Pang, Xinming Wang.  (2024)  Preparation of a three-dimensional bimetallic CoFex/ N-doped carbon nanomaterial used as modified electrode for the efficient electrochemical detection of l-tyrosine.  MATERIALS CHEMISTRY AND PHYSICS,      [PMID:] [10.1016/j.matchemphys.2024.129003]

73. Luzheng Dong, Jun Wu, Xiashi Zhu.  (2024)  Preparation of amino acid chiral ionic liquid and visual chiral recognition of glutamine and phenylalanine enantiomers.  CHIRALITY,  36  (4): (e23665).  [PMID:38570326] [10.1002/chir.23665]

74. Zhou Mengyan, Zhang Zhihui, Zheng Qi, Yu Mingdi, Si Mengxu, Wu Sirui, Zhang Yanan, Ding Shushu, Fu Ding-Yi.  (2025)  Ratiometric fluorescence quantification of folic acid utilizing D-penicillamine-based carbon dots in conjunction with glutathione S-transferase-Au nanoclusters.  MICROCHIMICA ACTA,  192  (4): (1-13).  [PMID:40080078] [10.1007/s00604-025-07062-8]

75. Wenjun Zhang, Chuntao Dong, Zhaosheng Li, Huina Shi, Yijun Xu, Mingchen Zhu.  (2024)  Serum targeted metabolomics uncovering specific amino acid signature for diagnosis of intrahepatic cholangiocarcinoma.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:39241676] [10.1016/j.jpba.2024.116457]

76. Meilin Hao, Junhong Zhu, Yuxiao Xie, Wenjie Cheng, Lanlan Yi, Sumei Zhao.  (2024)  Targeted metabolomics of muscle amino acid profles and hepatic transcriptomics analyses in grass carp (Ctenopharyngodon idellus) fed with broad beans.  Heliyon,      [PMID:39386830] [10.1016/j.heliyon.2024.e38323]

77. Lu Qin, Zhixiang Cui, Ziwei Zhang, Qiyao Zhai, Yu Wu, Jian Guan, Enyu Xu, Xin Zhang, Shirui Mao.  (2025)  Biomimetic chitosan derivatives inspired by cell-penetrating peptides for enhanced octreotide absorption following lung delivery.  CARBOHYDRATE POLYMERS,      [PMID:40973249] [10.1016/j.carbpol.2025.124251]

78. Fukai Li, Jian Zhou, Kai Li, Min Wang, Mengrui Yang, Ping Gong, Liang Li.  (2025)  Ln-MOF based magnetic composite nanosensor for sensitive dual-mode fluorescence/colorimetric detection of fluoroquinolones.  FOOD CHEMISTRY,      [PMID:40929988] [10.1016/j.foodchem.2025.146313]

79. Hongyu Li, Li Cen, Shiyu Liu, Ziqing Qiu, Yanfei Zhang, Xingyu Luo.  (2025)  Preparation of copper-based protein-inorganic hybrid nanoflowers with peroxidase-like activity for colorimetric detection of biothiols.  ANALYTICA CHIMICA ACTA,      [PMID:41093535] [10.1016/j.aca.2025.344685]

80. Yushuang Guo, Mingli Chen, Ting Yang, Jianhua Wang.  (2023)  Ratio-Metric Fluorescence/Colorimetric and Smartphone-Assisted Visualization for the Detection of Dopamine Based on Cu-MOF with Catecholase-like Activity.  Chemosensors,  11  (8): (431).  [PMID:] [10.3390/chemosensors11080431]

81. Xiao-Qing Lin, Hao-Hua Deng, Gang-Wei Wu, Hua-Ping Peng, Ai-Lin Liu, Xin-Hua Lin, Xing-Hua Xia, Wei Chen.  (2015)  Platinum nanoparticles/graphene-oxide hybrid with excellent peroxidase-like activity and its application for cysteine detection.  ANALYST,  140  (15): (5251-5256).  [PMID:26075633] [10.1039/C5AN00809C]

82. Mei Lin, Wei Bingjie, Liu Chunyan, Zhao Mengting, Cui Tian, Wei Xiangyang.  (2025)  Polyvinylpyrrolidone-stabilized ultra-small Fe3O4 nanoparticles-functionalized graphene oxide with synergistically enhanced peroxidase-like activity for glutathione colorimetric determination in rat serum.  MICROCHIMICA ACTA,  192  (4): (1-11).  [PMID:40131482] [10.1007/s00604-025-07044-w]

83. Bixia Huang, Xuewen Hu, Jiancheng Wang, Ping Li, Jun Chen.  (2019)  Study on chemical constituents of herbal formula Er Miao Wan and GC–MS based metabolomics approach to evaluate its therapeutic effects on hyperuricemic rats.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:31030102] [10.1016/j.jchromb.2019.04.032]

84. Riliga Wu, Hongyu Dai, Weijiang Guan, Chao Lu.  (2025)  Clusteroluminescence from Random Aggregation of Micrometers to Ordered Assembly of Sub-10 Nanometers by Space-Confined Template Synthesis.  Small,      [PMID:40376892] [10.1002/smll.202412133]

85. Xinqi Xu, Xialian Wang, Lian Xu, Bingmei Su, Juan Lin, Qiaobin Chen.  (2025)  Engineering of isoleucine dioxygenase for efficient multi-enzymatic cascade synthesis of (2S, 3R, 4S)-4-hydroxyisoleucine.  BIOORGANIC CHEMISTRY,      [PMID:41202682] [10.1016/j.bioorg.2025.109198]

86. Yifan Liu, Yiyu Yang, Minjie Peng, Wen Zang, Chaozhen Wang, Yuenan Zhang, Changyong Gao, Aiguo Wu, Yujie Zhang.  (2025)  Rapid colorimetric detection of the anticoagulant heparin based on an etching mechanism using I- responsive Cu-Au NPs.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.116349]

87. Karsoon Tan, Yu Hao, Kun Wang, Xin Li, Zhou Wu, Kit-Leong Cheong.  (2025)  Amino acid profile, fatty acid profile and status of non-essential trace metals of marketed bivalves from the Maowei Sea, China.  ESTUARINE COASTAL AND SHELF SCIENCE,      [PMID:] [10.1016/j.ecss.2025.109652]

88. Chenyan Lu, Dajie Zou, Yanyan Jia, Yongchang Lu, Huan Wang, Yanfeng He.  (2025)  A dual-signal sensing platform based on NCl-CQDs/DCIP fluorescence and colorimetry for the rapid detection of AA.  OPTICAL MATERIALS,      [PMID:] [10.1016/j.optmat.2025.117647]

89. Jie Du, Chaoqun Li, Li Chai, Fabao Zhao, Lin Lv, Zongcheng Yang, Zhiyuan Zhao, Rong Gong, Liu Yang, Meng Wu, Meng Nie, Jihui Jia, Dongwei Kang, Chengjiang Gao, Wei Zhao, Mutian Jia.  (2026)  Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses.  MOLECULAR CELL,  86  (4): (722-739).  [PMID:41653919] [10.1016/j.molcel.2026.01.010]

90. Yingying Zeng, Weiwei He, Yuhao Li, Junyi Yin, Mingyong Xie.  (2026)  Effects of Phenylalanine, Valine, Isoleucine, and Leucine on the Composition and Flavor of Lactic Acid Bacteria-Fermented Celery.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2026.108557]

91. Yuxun Zhao, Qiuhua Wu, Lu Bai, Chenghuan Wang, Guolin Zhang, Wenxiao Yang.  (2026)  Blue Fluorescent Carbon Dots Synthesized From PBAT and PET Waste Plastics and Their Detection of Gefitinib.  LUMINESCENCE,  41  (2): (e70439).  [PMID:41638228] [10.1002/bio.70439]

92. Simin Zhang, Xiangfeng Chen, Yaping Shi, Xiangyu Zhu, Zongwei Cai.  (2026)  Soft-Chain-Induced Ultrahigh-Resolution Chiral Separation of Amino Acids via Bimetallic Immobilization in MALDI-TIMS-MS.  ANALYTICAL CHEMISTRY,      [PMID:41701523] [10.1021/acs.analchem.5c07869]