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· · COA & SDS available for every product · Same-day shipping on in-stock items Veliparib - Moligand™, ≥99% , PARP 1, 2 and 3 inhibitor, CAS No.912444-00-9, PARP 1, 2 and 3 inhibitor
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99% Synonyms
ABT-888|2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide|1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)-|ABT888 (free base)|Veliparib (ABT-888 hydrochloride)|1H-BENZIMIDAZOLE-7-CARBOXAMIDE, 2-((2R)-2-METHYL-2-PYRROLIDINYL)-|(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide (VELIPARIB)|2-((2R)-2-methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide|benzimidazole carboxamide, 3a|2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide|2-[(R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide;|PARP-1 INHIBITOR ABT-888|Veliparib|2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-carboxamide|(R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide|2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide|ABT-695|VELIPARIB [WHO-DD]|Veliparib (ABT-888)|Lecithin, bovine|(R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide|2-((r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide|ABT-888 (Veliparib)|Antibiotic from Penicillium cyaneum|(2r)-2-(7-Carbamoyl-1h-Benzimidazol-2-Yl)-2-Methylpyrrolidinium|A 861695|VELIPARIB [INN]|A-861695|Carbomicina [INN-Spanish]|2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-|VELIPARIB [JAN]|2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide|Veliparib (JAN/USAN/INN)|2-((2r)-2-methyl-2-pyrrolidinyl)-1h-benzimidazole-7-carboxamide|2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-7-carboxamide|FLAVO|ABT 888|Veliparib free base|VELIPARIB [USAN]
Overview Veliparib is a potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition.
Specifications Synonyms
ABT-888 | 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide | 1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)- | ABT888 (free base) | Veliparib (ABT-888 hydrochloride) | 1H-BENZIMIDAZOLE-7-CARBOXAMIDE, 2-((2R)-2-METHYL-2-PYRROLIDINYL)- | (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide (VELIPARIB Show more
Specifications & Purity
Moligand™, ≥99%
Biochemical and Physiological Mechanisms
Veliparib is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively.
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
PARP 1, 2 and 3 inhibitor
Product Properties Names and Identifiers Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/504766842
Canonical Smiles
CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
IUPAC Name
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide
InChIKey
JNAHVYVRKWKWKQ-CYBMUJFWSA-N
INCHI
1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1
Isomeric SMILES
C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Benzimidazoles Subclass Not available Intermediate Tree Nodes Not available Direct Parent Benzimidazoles Alternative Parents Aralkylamines Benzenoids Pyrrolidines Imidazoles Heteroaromatic compounds Primary carboxylic acid amides Amino acids and derivatives Dialkylamines Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Benzimidazole - Aralkylamine - Benzenoid - Azole - Imidazole - Pyrrolidine - Heteroaromatic compound - Amino acid or derivatives - Carboxamide group - Primary carboxylic acid amide - Secondary aliphatic amine - Carboxylic acid derivative - Secondary amine - Azacycle - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Amine - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds). External Descriptors benzimidazoles Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates (CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility DMSO ≥45mg/mL Water <1.2mg/mL Ethanol <1.2.mg/mL Molecular Weight 244.290 g/mol XLogP3 0.500 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3 Rotatable Bond Count 2 Exact Mass 244.132 Da Monoisotopic Mass 244.132 Da Topological Polar Surface Area 83.800 Ų Heavy Atom Count 18 Formal Charge 0 Complexity 348.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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