6-Carboxy-tetramethylrhodamine N-succinimidyl ester - for fluorescence analysis, ≥90% , CAS No.150810-69-8

CAS: 150810-69-8 Cat. No.: C115507 Molecular Weight: 527.52 EC Number: 634-901-0

GRADE & PURITY for Fluorescence analysis, ≥90%

Synonyms

PD100622 | 2-[3-(dimethylamino)-6-dimethylazaniumylidenexanthen-9-yl]-4-(2,5-dioxopyrrolidin-1-yl)oxycarbonylbenzoate | 6-Carboxytetramethylrhodamine N-succinimidyl ester | J-100078 | 6-TAMRA-NHS ester6-TAMRA-NHS ester | F12264 | AKOS015914674 | 5-TAMRA-N

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

6-TAMRA SE is useful in the fluorescent labeling of peptides and aminoglycoside antibiotics post chemical modification. 6-TAMRA SE is often used in automated DNA sequencing.
A fluorescent indicator

Specifications

Synonyms

PD100622 | 2-[3-(dimethylamino)-6-dimethylazaniumylidenexanthen-9-yl]-4-(2, 5-dioxopyrrolidin-1-yl)oxycarbonylbenzoate | 6-Carboxytetramethylrhodamine N-succinimidyl ester | J-100078 | 6-TAMRA-NHS ester6-TAMRA-NHS ester | F12264 | AKOS015914674 | 5-TAMRA-N

Specifications & Purity

for fluorescence analysis, ≥90%

Biochemical and Physiological Mechanisms

Fluorophore for peptide, protein, nucleotide and nucleic acid conjugation. Fluorescent dye for oligonucleotide labeling and automated DNA sequencing. Labels aminoglycoside antibiotics after modification.

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

for Fluorescence analysis

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥90%

Names and Identifiers

• Canonical Smiles: CN(C)C1=CC2=C(C=C1)C(=C3C=CC(=[N+](C)C)C=C3O2)C4=C(C=CC(=C4)C(=O)ON5C(=O)CCC5=O)C(=O)[O-]
• IUPAC Name: 2-[3-(dimethylamino)-6-dimethylazaniumylidenexanthen-9-yl]-4-(2,5-dioxopyrrolidin-1-yl)oxycarbonylbenzoate
• InChIKey: PAOQTZWNYMMSEE-UHFFFAOYSA-N
• INCHI: 1S/C29H25N3O7/c1-30(2)17-6-9-20-23(14-17)38-24-15-18(31(3)4)7-10-21(24)27(20)22-13-16(5-8-19(22)28(35)36)29(37)39-32-25(33)11-12-26(32)34/h5-10,13-15H,11-12H2,1-4H3
• Isomeric SMILES: CN(C)C1=CC2=C(C=C1)C(=C3C=CC(=[N+](C)C)C=C3O2)C4=C(C=CC(=C4)C(=O)ON5C(=O)CCC5=O)C(=O)[O-]
• WGK Germany: 3
• Molecular Weight: 527.52
• Reaxy-Rn: 8458897
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8458897&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Benzopyrans
      • Subclass 1-benzopyrans
        • Level5 Dibenzopyrans
          • Level6 Xanthenes

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Dibenzopyrans
• Direct Parent: Xanthenes
• Alternative Parents: P-phthalic acid and derivatives Benzoic acids Benzoyl derivatives Dialkylarylamines Pyrrolidine-2-ones Dicarboxylic acids and derivatives Secondary ketimines Dicarboximides Heteroaromatic compounds Amino acids Carboxylic acid salts Lactams Carboxylic acids Azacyclic compounds Oxacyclic compounds Organic salts Organic zwitterions Carbonyl compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Xanthene - Para_phthalic_acid - Benzoic acid or derivatives - Benzoic acid - Benzoyl - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Pyrrolidone - 2-pyrrolidone - Benzenoid - Secondary ketimine - Heteroaromatic compound - Pyrrolidine - Dicarboximide - Tertiary amine - Amino acid - Carboxylic acid salt - Lactam - Amino acid or derivatives - Oxacycle - Azacycle - Carboxylic acid derivative - Carboxylic acid - Organic zwitterion - Organonitrogen compound - Organooxygen compound - Organic oxide - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organic salt - Amine - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as xanthenes. These are polycyclic aromatic compounds containing a xanthene moiety, which consists of two benzene rings joined to each other by a pyran ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in DMSO, DMF, and acetonitrile.
• Sensitivity: Light & Moisture sensitive
• Molecular Weight: 527.500 g/mol
• XLogP3: 2.600
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 527.169 Da
• Monoisotopic Mass: 527.169 Da
• Topological Polar Surface Area: 119.000 Ų
• Heavy Atom Count: 39
• Formal Charge: 0
• Complexity: 1140.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1